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• W4323344780 startingPage "137" @default.
• W4323344780 abstract "Polyelectrolyte complexes and the derivatives thereof comprise some of the most promising vehicles for the encapsulation and delivery of macromolecular therapeutics. In particular, protein therapeutics, which present a host of special considerations, can often be effectively packaged and delivered using interpolyelectrolyte complexes. While the technologies are still in the developmental phase, there are numerous examples of complexes where control is exerted over spacial and temporal delivery of a model protein cargo or candidate protein therapeutic agent. Here we provide a historical and practical background to promote a deeper understanding of interpolyelectrolyte complexes and the derivative technologies. Additionally, we review the physical principles underlying the association of polyelectrolyte complexes and the application of those principles to novel strategies and technologies driving interpolyelectrolyte complexation. Then, the application of polyelectrolyte complex technology to protein therapeutics is discussed in detail including discussions of several types of protein cargo with a special emphasis on Brain-Derived Neurotrophic Factor. Finally, we focus on the use of stealth polymers in block ionomer complexes, specifically PEG; its benefits, flaws, and possible alternatives. Comprehensive understanding of the field may promote the continued development of derivative technologies for the delivery of particularly intransigent protein therapeutics, much as has been accomplished for small molecule drugs. We also aim to link current advances to the historical developments which inaugurated the field. With consideration to the field, industrial and academic researchers can utilize the discussed technologies and continue to elucidate novel modalities for a myriad of therapeutic and commercial applications." @default.
• W4323344780 created "2023-03-08" @default.
• W4323344780 creator A5029598800 @default.
• W4323344780 creator A5076771857 @default.
• W4323344780 date "2022-09-01" @default.
• W4323344780 modified "2023-09-25" @default.
• W4323344780 title "Interpolyelectrolyte Complexes as an Emerging Technology for Pharmaceutical Delivery of Polypeptides" @default.
• W4323344780 cites W1486638502 @default.
• W4323344780 cites W1490299254 @default.
• W4323344780 cites W1494872149 @default.
• W4323344780 cites W1518149340 @default.
• W4323344780 cites W155554955 @default.
• W4323344780 cites W1563515257 @default.
• W4323344780 cites W1598421774 @default.
• W4323344780 cites W1925665128 @default.
• W4323344780 cites W1963122402 @default.
• W4323344780 cites W1963620584 @default.
• W4323344780 cites W1966987311 @default.
• W4323344780 cites W1967460542 @default.
• W4323344780 cites W1970396011 @default.
• W4323344780 cites W1972280500 @default.
• W4323344780 cites W1973316675 @default.
• W4323344780 cites W1973657067 @default.
• W4323344780 cites W1973773973 @default.
• W4323344780 cites W1976442478 @default.
• W4323344780 cites W1979996756 @default.
• W4323344780 cites W1980137653 @default.
• W4323344780 cites W1980248898 @default.
• W4323344780 cites W1980436311 @default.
• W4323344780 cites W1980522922 @default.
• W4323344780 cites W1984932551 @default.
• W4323344780 cites W1985921803 @default.
• W4323344780 cites W1987888236 @default.
• W4323344780 cites W1988771401 @default.
• W4323344780 cites W1990447486 @default.
• W4323344780 cites W1991815980 @default.
• W4323344780 cites W1994706925 @default.
• W4323344780 cites W1995024825 @default.
• W4323344780 cites W1995621073 @default.
• W4323344780 cites W1995764678 @default.
• W4323344780 cites W1997789582 @default.
• W4323344780 cites W1998071243 @default.
• W4323344780 cites W2001413029 @default.
• W4323344780 cites W2001539590 @default.
• W4323344780 cites W2003665687 @default.
• W4323344780 cites W2006209142 @default.
• W4323344780 cites W2008243768 @default.
• W4323344780 cites W2009826568 @default.
• W4323344780 cites W2010154654 @default.
• W4323344780 cites W2012086426 @default.
• W4323344780 cites W2012796790 @default.
• W4323344780 cites W2013245338 @default.
• W4323344780 cites W2014061473 @default.
• W4323344780 cites W2014758974 @default.
• W4323344780 cites W2015069884 @default.
• W4323344780 cites W2018569753 @default.
• W4323344780 cites W2019681888 @default.
• W4323344780 cites W2020404187 @default.
• W4323344780 cites W2023254345 @default.
• W4323344780 cites W2024051532 @default.
• W4323344780 cites W2025111276 @default.
• W4323344780 cites W2026015980 @default.
• W4323344780 cites W2026727241 @default.
• W4323344780 cites W2028209124 @default.
• W4323344780 cites W2028290931 @default.
• W4323344780 cites W2029558817 @default.
• W4323344780 cites W2032578229 @default.
• W4323344780 cites W2036357680 @default.
• W4323344780 cites W2036452980 @default.
• W4323344780 cites W2039963993 @default.
• W4323344780 cites W2041082484 @default.
• W4323344780 cites W2042596139 @default.
• W4323344780 cites W2043399444 @default.
• W4323344780 cites W2043510135 @default.
• W4323344780 cites W2045452662 @default.
• W4323344780 cites W2045573038 @default.
• W4323344780 cites W2046793835 @default.
• W4323344780 cites W2048193235 @default.
• W4323344780 cites W2049704985 @default.
• W4323344780 cites W2051075452 @default.
• W4323344780 cites W2053296997 @default.
• W4323344780 cites W2055378600 @default.
• W4323344780 cites W2058453409 @default.
• W4323344780 cites W2058645489 @default.
• W4323344780 cites W2061093127 @default.
• W4323344780 cites W2063173103 @default.
• W4323344780 cites W2064061802 @default.
• W4323344780 cites W2064706621 @default.
• W4323344780 cites W2064909929 @default.
• W4323344780 cites W2065992506 @default.
• W4323344780 cites W2066577103 @default.
• W4323344780 cites W2066790769 @default.
• W4323344780 cites W2069929140 @default.
• W4323344780 cites W2070292061 @default.
• W4323344780 cites W2070794824 @default.
• W4323344780 cites W2072710599 @default.
• W4323344780 cites W2073003323 @default.
• W4323344780 cites W2073737589 @default.

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