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- W4323347687 abstract "Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging therapy still suffers from the low response rates and immune-related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic therapy (SDT), as a non-invasive treatment, has received ever-increasing attention especially in the treatment of deep-seated tumors. Significantly, SDT can effectively induce immunogenic cell death to trigger systemic anti-tumor immune response, termed sonodynamic immunotherapy. The rapid development of nanotechnology has revolutionized SDT effects with robust immune response induction. As a result, more and more innovative nanosonosensitizers and synergistic treatment modalities are established with superior efficacy and safe profile. In this review, the recent advances in cancer sonodynamic immunotherapy are summarized with a particular emphasis on how nanotechnology can be explored to harness SDT for amplifying anti-tumor immune response. Moreover, the current challenges in this field and the prospects for its clinical translation are also presented. It is anticipated that this review can provide rational guidance and facilitate the development of nanomaterials-assisted sonodynamic immunotherapy, helping to pave the way for next-generation cancer therapy and eventually achieve a durable response in patients." @default.
- W4323347687 created "2023-03-08" @default.
- W4323347687 creator A5003292833 @default.
- W4323347687 creator A5006012404 @default.
- W4323347687 creator A5018249388 @default.
- W4323347687 creator A5024994504 @default.
- W4323347687 creator A5048924584 @default.
- W4323347687 creator A5070568188 @default.
- W4323347687 date "2023-06-29" @default.
- W4323347687 modified "2023-10-18" @default.
- W4323347687 title "Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy" @default.
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