FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323347718> ?p ?o ?g. }

• W4323347718 endingPage "13588" @default.
• W4323347718 startingPage "13576" @default.
• W4323347718 abstract "The application of RNA interference (RNAi) technology for pest control is environmentally friendly and accurate. However, the efficiency of RNAi is often inconsistent and unreliable, and finding a suitable carrier element is considered critical to success in overcoming biotic and abiotic barriers to reach the target site. The fall armyworm, Spodoptera frugiperda (FAW), which is one of most important global agricultural pests, has recently spread rapidly to other parts of the world. In this study, a method to improve the stability and RNAi efficiency of the dsRNA carrier complex was reported. Methoprene-tolerant gene (Met) was selected as a target, a gene which is critical to the growth and development of FAW. Biomaterials nanoliposomes (LNPs) were modified with polyethylenimine (PEI) to deliver the dsRNA of Met. The synthesized Met3@PEI@LNPs reached a size of 385 nm and were found to load dsRNA effectively. Through stability and protection assays, it was found that LNPs provided reliable protection. In addition, the release curve also demonstrated that LNPs were able to prevent premature release under alkaline condition of the insect midgut but accelerate the release after entering the acidic environment of the target cells. The cell transfection efficiency of the prepared LNPs reached 96.4%. Toxicity tests showed that the use of LNPs could significantly improve the interference efficiency, with 91.7% interference efficiency achieved when the concentration of dsRNA in LNPs was only 25% of that of the control. Successful interference of Met demonstrated it could significantly shorten the larval period and make the larvae pupate earlier, thus achieving the purpose of control. In this study, we have demonstrated the use of nanotechnology to provide a novel RNAi delivery method for pest control." @default.
• W4323347718 created "2023-03-08" @default.
• W4323347718 creator A5014008836 @default.
• W4323347718 creator A5020204794 @default.
• W4323347718 creator A5036735358 @default.
• W4323347718 creator A5038519600 @default.
• W4323347718 creator A5054077149 @default.
• W4323347718 creator A5062071376 @default.
• W4323347718 creator A5062189166 @default.
• W4323347718 creator A5070704451 @default.
• W4323347718 creator A5074924751 @default.
• W4323347718 creator A5083487181 @default.
• W4323347718 date "2023-03-07" @default.
• W4323347718 modified "2023-09-23" @default.
• W4323347718 title "Delivery of Methoprene-Tolerant dsRNA to Improve RNAi Efficiency by Modified Liposomes for Pest Control" @default.
• W4323347718 cites W1647075334 @default.
• W4323347718 cites W1935441847 @default.
• W4323347718 cites W1978873223 @default.
• W4323347718 cites W1981855431 @default.
• W4323347718 cites W1992010964 @default.
• W4323347718 cites W2000647389 @default.
• W4323347718 cites W2008028087 @default.
• W4323347718 cites W2011836205 @default.
• W4323347718 cites W2026257148 @default.
• W4323347718 cites W2041649971 @default.
• W4323347718 cites W2058333505 @default.
• W4323347718 cites W2065946677 @default.
• W4323347718 cites W2079445254 @default.
• W4323347718 cites W2102055218 @default.
• W4323347718 cites W2109833608 @default.
• W4323347718 cites W2133750453 @default.
• W4323347718 cites W2179624237 @default.
• W4323347718 cites W2229301582 @default.
• W4323347718 cites W2418166999 @default.
• W4323347718 cites W2600060242 @default.
• W4323347718 cites W2742619964 @default.
• W4323347718 cites W2784014313 @default.
• W4323347718 cites W2789971483 @default.
• W4323347718 cites W2791697159 @default.
• W4323347718 cites W2795367523 @default.
• W4323347718 cites W2802063824 @default.
• W4323347718 cites W2887781670 @default.
• W4323347718 cites W2904489623 @default.
• W4323347718 cites W2916303232 @default.
• W4323347718 cites W2938241454 @default.
• W4323347718 cites W2943769781 @default.
• W4323347718 cites W2948755886 @default.
• W4323347718 cites W2953980887 @default.
• W4323347718 cites W2969904463 @default.
• W4323347718 cites W2970947974 @default.
• W4323347718 cites W2979248614 @default.
• W4323347718 cites W3013750222 @default.
• W4323347718 cites W3029369162 @default.
• W4323347718 cites W3097245020 @default.
• W4323347718 cites W3098002395 @default.
• W4323347718 cites W3130004977 @default.
• W4323347718 cites W3131605066 @default.
• W4323347718 cites W3157107884 @default.
• W4323347718 cites W3189341157 @default.
• W4323347718 cites W3214471923 @default.
• W4323347718 cites W4205462258 @default.
• W4323347718 cites W4220657964 @default.
• W4323347718 cites W4220683345 @default.
• W4323347718 cites W4220961141 @default.
• W4323347718 cites W4226420220 @default.
• W4323347718 doi "https://doi.org/10.1021/acsami.2c20151" @default.
• W4323347718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36880527" @default.
• W4323347718 hasPublicationYear "2023" @default.
• W4323347718 type Work @default.
• W4323347718 citedByCount "0" @default.
• W4323347718 crossrefType "journal-article" @default.
• W4323347718 hasAuthorship W4323347718A5014008836 @default.
• W4323347718 hasAuthorship W4323347718A5020204794 @default.
• W4323347718 hasAuthorship W4323347718A5036735358 @default.
• W4323347718 hasAuthorship W4323347718A5038519600 @default.
• W4323347718 hasAuthorship W4323347718A5054077149 @default.
• W4323347718 hasAuthorship W4323347718A5062071376 @default.
• W4323347718 hasAuthorship W4323347718A5062189166 @default.
• W4323347718 hasAuthorship W4323347718A5070704451 @default.
• W4323347718 hasAuthorship W4323347718A5074924751 @default.
• W4323347718 hasAuthorship W4323347718A5083487181 @default.
• W4323347718 hasConcept C104317684 @default.
• W4323347718 hasConcept C166703698 @default.
• W4323347718 hasConcept C2191507 @default.
• W4323347718 hasConcept C22615655 @default.
• W4323347718 hasConcept C54009773 @default.
• W4323347718 hasConcept C55493867 @default.
• W4323347718 hasConcept C67705224 @default.
• W4323347718 hasConcept C86803240 @default.
• W4323347718 hasConcept C95444343 @default.
• W4323347718 hasConceptScore W4323347718C104317684 @default.
• W4323347718 hasConceptScore W4323347718C166703698 @default.
• W4323347718 hasConceptScore W4323347718C2191507 @default.
• W4323347718 hasConceptScore W4323347718C22615655 @default.
• W4323347718 hasConceptScore W4323347718C54009773 @default.
• W4323347718 hasConceptScore W4323347718C55493867 @default.
• W4323347718 hasConceptScore W4323347718C67705224 @default.
• W4323347718 hasConceptScore W4323347718C86803240 @default.

• next