Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323347730> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4323347730 endingPage "019937" @default.
- W4323347730 startingPage "jnis" @default.
- W4323347730 abstract "Hyperdense cerebral artery sign (HCAS) is an imaging biomarker in acute ischemic stroke (AIS) that has been shown to be associated with various clinical outcomes and stroke etiology. While prior studies have correlated HCAS with histopathological composition of cerebral thrombus, it is unknown whether and to what extent HCAS is also associated with distinct clot protein composition.Thromboembolic material from 24 patients with AIS were retrieved via mechanical thrombectomy and evaluated with mass spectrometry in order to characterize their proteomic composition. Presence (+) or absence (-) of HCAS on preintervention non-contrast head CT was then determined and correlated with thrombus protein signature with abundance of individual proteins calculated as a function HCAS status.24 clots with 1797 distinct proteins in total were identified. 14 patients were HCAS(+) and 10 were HCAS(-). HCAS(+) were most significantly differentially abundant in actin cytoskeletal protein (P=0.002, Z=2.82), bleomycin hydrolase (P=0.007, Z=2.44), arachidonate 12-lipoxygenase (P=0.004, Z=2.60), and lysophospholipase D (P=0.007, Z=2.44), among other proteins; HCAS(-) clots were differentially enriched in soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (P=0.0009, Z=3.11), tyrosine-protein kinase Fyn (P=0.002, Z=2.84), and several complement proteins (P<0.05, Z>1.71 for all), among numerous other proteins. Additionally, HCAS(-) thrombi were enriched in biological processes involved with plasma lipoprotein and protein-lipid remodeling/assembling, and lipoprotein metabolic processes (P<0.001), as well as cellular components including mitochondria (P<0.001).HCAS is reflective of distinct proteomic composition in AIS thrombus. These findings suggest that imaging can be used to identify mechanisms of clot formation or maintenance at the protein level, and might inform future research on thrombus biology and imaging characterization." @default.
- W4323347730 created "2023-03-08" @default.
- W4323347730 creator A5000474756 @default.
- W4323347730 creator A5007118529 @default.
- W4323347730 creator A5007686209 @default.
- W4323347730 creator A5011259026 @default.
- W4323347730 creator A5015970548 @default.
- W4323347730 creator A5021467955 @default.
- W4323347730 creator A5025487414 @default.
- W4323347730 creator A5031605441 @default.
- W4323347730 creator A5043944872 @default.
- W4323347730 creator A5073187096 @default.
- W4323347730 creator A5073451932 @default.
- W4323347730 creator A5088592390 @default.
- W4323347730 date "2023-03-06" @default.
- W4323347730 modified "2023-10-16" @default.
- W4323347730 title "CT hyperdense cerebral artery sign reflects distinct proteomic composition in acute ischemic stroke thrombus" @default.
- W4323347730 cites W1588757304 @default.
- W4323347730 cites W1976256366 @default.
- W4323347730 cites W2004971895 @default.
- W4323347730 cites W2005144667 @default.
- W4323347730 cites W2023766772 @default.
- W4323347730 cites W2037690972 @default.
- W4323347730 cites W2038963685 @default.
- W4323347730 cites W2084388883 @default.
- W4323347730 cites W2104852105 @default.
- W4323347730 cites W2132914997 @default.
- W4323347730 cites W2134571812 @default.
- W4323347730 cites W2142768368 @default.
- W4323347730 cites W2333532109 @default.
- W4323347730 cites W2369651267 @default.
- W4323347730 cites W2751276118 @default.
- W4323347730 cites W2794318172 @default.
- W4323347730 cites W2991106430 @default.
- W4323347730 cites W3034620364 @default.
- W4323347730 cites W3046272620 @default.
- W4323347730 cites W3095501243 @default.
- W4323347730 cites W3097797147 @default.
- W4323347730 cites W3124833794 @default.
- W4323347730 cites W3131122645 @default.
- W4323347730 cites W3160820307 @default.
- W4323347730 cites W4224241657 @default.
- W4323347730 cites W4283455848 @default.
- W4323347730 cites W4285026203 @default.
- W4323347730 cites W4286560377 @default.
- W4323347730 cites W4294214983 @default.
- W4323347730 doi "https://doi.org/10.1136/jnis-2022-019937" @default.
- W4323347730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36878687" @default.
- W4323347730 hasPublicationYear "2023" @default.
- W4323347730 type Work @default.
- W4323347730 citedByCount "0" @default.
- W4323347730 crossrefType "journal-article" @default.
- W4323347730 hasAuthorship W4323347730A5000474756 @default.
- W4323347730 hasAuthorship W4323347730A5007118529 @default.
- W4323347730 hasAuthorship W4323347730A5007686209 @default.
- W4323347730 hasAuthorship W4323347730A5011259026 @default.
- W4323347730 hasAuthorship W4323347730A5015970548 @default.
- W4323347730 hasAuthorship W4323347730A5021467955 @default.
- W4323347730 hasAuthorship W4323347730A5025487414 @default.
- W4323347730 hasAuthorship W4323347730A5031605441 @default.
- W4323347730 hasAuthorship W4323347730A5043944872 @default.
- W4323347730 hasAuthorship W4323347730A5073187096 @default.
- W4323347730 hasAuthorship W4323347730A5073451932 @default.
- W4323347730 hasAuthorship W4323347730A5088592390 @default.
- W4323347730 hasConcept C126322002 @default.
- W4323347730 hasConcept C127413603 @default.
- W4323347730 hasConcept C142724271 @default.
- W4323347730 hasConcept C164705383 @default.
- W4323347730 hasConcept C2780645631 @default.
- W4323347730 hasConcept C2781362458 @default.
- W4323347730 hasConcept C71924100 @default.
- W4323347730 hasConcept C78519656 @default.
- W4323347730 hasConceptScore W4323347730C126322002 @default.
- W4323347730 hasConceptScore W4323347730C127413603 @default.
- W4323347730 hasConceptScore W4323347730C142724271 @default.
- W4323347730 hasConceptScore W4323347730C164705383 @default.
- W4323347730 hasConceptScore W4323347730C2780645631 @default.
- W4323347730 hasConceptScore W4323347730C2781362458 @default.
- W4323347730 hasConceptScore W4323347730C71924100 @default.
- W4323347730 hasConceptScore W4323347730C78519656 @default.
- W4323347730 hasLocation W43233477301 @default.
- W4323347730 hasLocation W43233477302 @default.
- W4323347730 hasOpenAccess W4323347730 @default.
- W4323347730 hasPrimaryLocation W43233477301 @default.
- W4323347730 hasRelatedWork W1801500037 @default.
- W4323347730 hasRelatedWork W2008851126 @default.
- W4323347730 hasRelatedWork W2011347913 @default.
- W4323347730 hasRelatedWork W2049397185 @default.
- W4323347730 hasRelatedWork W2074833529 @default.
- W4323347730 hasRelatedWork W2159512267 @default.
- W4323347730 hasRelatedWork W2304633692 @default.
- W4323347730 hasRelatedWork W2358192447 @default.
- W4323347730 hasRelatedWork W2399063111 @default.
- W4323347730 hasRelatedWork W4313554662 @default.
- W4323347730 isParatext "false" @default.
- W4323347730 isRetracted "false" @default.
- W4323347730 workType "article" @default.