FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323348002> ?p ?o ?g. }

• W4323348002 endingPage "1070" @default.
• W4323348002 startingPage "1054" @default.
• W4323348002 abstract "Despite recent advances in the development of orthopedic devices, implant-related failures that occur as a result of poor osseointegration and nosocomial infection are frequent. In this study, we developed a multiscale titanium (Ti) surface topography that promotes both osteogenic and mechano-bactericidal activity using a simple two-step fabrication approach. The response of MG-63 osteoblast-like cells and antibacterial activity toward Pseudomonas aeruginosa and Staphylococcus aureus bacteria was compared for two distinct micronanoarchitectures of differing surface roughness created by acid etching, using either hydrochloric acid (HCl) or sulfuric acid (H2SO4), followed by hydrothermal treatment, henceforth referred to as either MN-HCl or MN-H2SO4. The MN-HCl surfaces were characterized by an average surface microroughness (Sa) of 0.8 ± 0.1 μm covered by blade-like nanosheets of 10 ± 2.1 nm thickness, whereas the MN-H2SO4 surfaces exhibited a greater Sa value of 5.8 ± 0.6 μm, with a network of nanosheets of 20 ± 2.6 nm thickness. Both micronanostructured surfaces promoted enhanced MG-63 attachment and differentiation; however, cell proliferation was only significantly increased on MN-HCl surfaces. In addition, the MN-HCl surface exhibited increased levels of bactericidal activity, with only 0.6% of the P. aeruginosa cells and approximately 5% S. aureus cells remaining viable after 24 h when compared to control surfaces. Thus, we propose the modulation of surface roughness and architecture on the micro- and nanoscale to achieve efficient manipulation of osteogenic cell response combined with mechanical antibacterial activity. The outcomes of this study provide significant insight into the further development of advanced multifunctional orthopedic implant surfaces." @default.
• W4323348002 created "2023-03-08" @default.
• W4323348002 creator A5003652299 @default.
• W4323348002 creator A5014598123 @default.
• W4323348002 creator A5019902061 @default.
• W4323348002 creator A5031862083 @default.
• W4323348002 creator A5035831750 @default.
• W4323348002 creator A5043958203 @default.
• W4323348002 creator A5058552736 @default.
• W4323348002 creator A5066401598 @default.
• W4323348002 creator A5068489341 @default.
• W4323348002 creator A5078904793 @default.
• W4323348002 date "2023-03-07" @default.
• W4323348002 modified "2023-10-17" @default.
• W4323348002 title "Modulation of MG-63 Osteogenic Response on Mechano-Bactericidal Micronanostructured Titanium Surfaces" @default.
• W4323348002 cites W132108806 @default.
• W4323348002 cites W1889564600 @default.
• W4323348002 cites W1963878748 @default.
• W4323348002 cites W1987654508 @default.
• W4323348002 cites W1992268588 @default.
• W4323348002 cites W1992872177 @default.
• W4323348002 cites W1994516276 @default.
• W4323348002 cites W1997913897 @default.
• W4323348002 cites W2008843476 @default.
• W4323348002 cites W2015558176 @default.
• W4323348002 cites W2015979204 @default.
• W4323348002 cites W2025492336 @default.
• W4323348002 cites W2041964092 @default.
• W4323348002 cites W2046576188 @default.
• W4323348002 cites W2055844463 @default.
• W4323348002 cites W2060459636 @default.
• W4323348002 cites W2069875032 @default.
• W4323348002 cites W2077930487 @default.
• W4323348002 cites W2078714250 @default.
• W4323348002 cites W2085138564 @default.
• W4323348002 cites W2088467308 @default.
• W4323348002 cites W2097577447 @default.
• W4323348002 cites W2128089445 @default.
• W4323348002 cites W2134574414 @default.
• W4323348002 cites W2144023435 @default.
• W4323348002 cites W2157366956 @default.
• W4323348002 cites W2159502578 @default.
• W4323348002 cites W2161873281 @default.
• W4323348002 cites W2162445598 @default.
• W4323348002 cites W2165462684 @default.
• W4323348002 cites W2345552136 @default.
• W4323348002 cites W2581168325 @default.
• W4323348002 cites W2593739390 @default.
• W4323348002 cites W2618550998 @default.
• W4323348002 cites W2623981860 @default.
• W4323348002 cites W2751855527 @default.
• W4323348002 cites W2773755576 @default.
• W4323348002 cites W2774005802 @default.
• W4323348002 cites W2792730605 @default.
• W4323348002 cites W2806283015 @default.
• W4323348002 cites W2901838922 @default.
• W4323348002 cites W2905961795 @default.
• W4323348002 cites W2909621381 @default.
• W4323348002 cites W2945494155 @default.
• W4323348002 cites W2981022755 @default.
• W4323348002 cites W2990939864 @default.
• W4323348002 cites W2991015907 @default.
• W4323348002 cites W2996082819 @default.
• W4323348002 cites W3009179423 @default.
• W4323348002 cites W3015306668 @default.
• W4323348002 cites W3045917270 @default.
• W4323348002 cites W3048987220 @default.
• W4323348002 cites W3093150654 @default.
• W4323348002 cites W3094323683 @default.
• W4323348002 cites W3095040554 @default.
• W4323348002 cites W3111081077 @default.
• W4323348002 cites W3118290089 @default.
• W4323348002 cites W3119148355 @default.
• W4323348002 cites W3125322901 @default.
• W4323348002 cites W3155580416 @default.
• W4323348002 cites W3204088775 @default.
• W4323348002 cites W3210647681 @default.
• W4323348002 cites W4200231820 @default.
• W4323348002 cites W4200520689 @default.
• W4323348002 doi "https://doi.org/10.1021/acsabm.2c00952" @default.
• W4323348002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36880728" @default.
• W4323348002 hasPublicationYear "2023" @default.
• W4323348002 type Work @default.
• W4323348002 citedByCount "1" @default.
• W4323348002 countsByYear W43233480022023 @default.
• W4323348002 crossrefType "journal-article" @default.
• W4323348002 hasAuthorship W4323348002A5003652299 @default.
• W4323348002 hasAuthorship W4323348002A5014598123 @default.
• W4323348002 hasAuthorship W4323348002A5019902061 @default.
• W4323348002 hasAuthorship W4323348002A5031862083 @default.
• W4323348002 hasAuthorship W4323348002A5035831750 @default.
• W4323348002 hasAuthorship W4323348002A5043958203 @default.
• W4323348002 hasAuthorship W4323348002A5058552736 @default.
• W4323348002 hasAuthorship W4323348002A5066401598 @default.
• W4323348002 hasAuthorship W4323348002A5068489341 @default.
• W4323348002 hasAuthorship W4323348002A5078904793 @default.
• W4323348002 hasConcept C100460472 @default.
• W4323348002 hasConcept C101414908 @default.

• next