FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323348318> ?p ?o ?g. }

• W4323348318 endingPage "1210" @default.
• W4323348318 startingPage "1196" @default.
• W4323348318 abstract "One of the important monitoring indicators of the air pollution is atmospheric fine particulate matter (PM2.5 ), which can induce lung inflammation after inhalation. Coelonin can alleviate PM2.5 -induced macrophage damage through anti-inflammation. However, its molecular mechanism remains unclear. We hypothesized that macrophage damage may involve the release of inflammatory cytokines, activation of inflammatory pathways, and pyrosis induced by inflammasome. In this study, we evaluated the anti-inflammation activity of coelonin in PM2.5 -induced macrophage and its mechanism of action. Nitric oxide (NO) and reactive oxygen species (ROS) production were measured by NO Assay kit and dichlorofluorescein-diacetate (DCFH-DA), and apoptosis were measured by Flow cytometry and TUNEL staining. The concentration of inflammatory cytokines production was measured with cytometric bead arrays and ELISA kits. The activation of NF-κB signaling pathway and NLRP3 inflammasome were measured by immunofluorescence, quantitative reverse transcription-polymerase chain reaction and western blot. As expected, coelonin pretreatment reduced NO production significantly as well as alleviated cell damage by decreasing ROS and apoptosis. It decreased generation of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in PM2.5 -induced RAW264.7 and J774A.1 cells. Moreover, coelonin markedly inhibited upregulating the expression of toll-like receptor (TLR)4 and cyclo-oxygenase (COX)-2, blocked activation of p-nuclear factor-kappa B (NF-κB) signaling pathway, and suppressed expression of NLRP3 inflammasome, ASC, GSDMD, IL-18 and IL-1β. In conclusion, the results showed that coelonin could protect against PM2.5 -induced macrophage damage via suppressing TLR4/NF-κB/COX-2 signaling pathway and NLRP3 inflammasome activation in vitro." @default.
• W4323348318 created "2023-03-08" @default.
• W4323348318 creator A5005526871 @default.
• W4323348318 creator A5018813034 @default.
• W4323348318 creator A5024406928 @default.
• W4323348318 creator A5032402772 @default.
• W4323348318 creator A5041402182 @default.
• W4323348318 creator A5055848895 @default.
• W4323348318 creator A5065852183 @default.
• W4323348318 creator A5088551350 @default.
• W4323348318 date "2023-03-07" @default.
• W4323348318 modified "2023-10-02" @default.
• W4323348318 title "Coelonin protects against <scp>PM₂</scp>_.5‐induced macrophage damage via suppressing <scp>TLR4</scp>/<scp>NF‐κB</scp>/<scp>COX</scp>‐2 signaling pathway and <scp>NLRP3</scp> inflammasome activation <i>in vitro</i>" @default.
• W4323348318 cites W1599437589 @default.
• W4323348318 cites W1900670142 @default.
• W4323348318 cites W1978653090 @default.
• W4323348318 cites W1982524205 @default.
• W4323348318 cites W2049928792 @default.
• W4323348318 cites W2137444266 @default.
• W4323348318 cites W2145001648 @default.
• W4323348318 cites W2200503738 @default.
• W4323348318 cites W2275537745 @default.
• W4323348318 cites W2467558113 @default.
• W4323348318 cites W2521574223 @default.
• W4323348318 cites W2522054313 @default.
• W4323348318 cites W2555268851 @default.
• W4323348318 cites W2588582380 @default.
• W4323348318 cites W2609836833 @default.
• W4323348318 cites W2617655798 @default.
• W4323348318 cites W2761586844 @default.
• W4323348318 cites W2801706622 @default.
• W4323348318 cites W2803170768 @default.
• W4323348318 cites W2883700824 @default.
• W4323348318 cites W2884445384 @default.
• W4323348318 cites W2887601832 @default.
• W4323348318 cites W2888001952 @default.
• W4323348318 cites W2919054694 @default.
• W4323348318 cites W2921788575 @default.
• W4323348318 cites W2923077634 @default.
• W4323348318 cites W2937142416 @default.
• W4323348318 cites W2957461818 @default.
• W4323348318 cites W2972283191 @default.
• W4323348318 cites W2984871787 @default.
• W4323348318 cites W2990931669 @default.
• W4323348318 cites W2991202137 @default.
• W4323348318 cites W3091680348 @default.
• W4323348318 cites W3116675996 @default.
• W4323348318 cites W3119977534 @default.
• W4323348318 cites W3159910055 @default.
• W4323348318 cites W3168768156 @default.
• W4323348318 cites W3187994802 @default.
• W4323348318 cites W4200408940 @default.
• W4323348318 cites W4225659815 @default.
• W4323348318 cites W4293458011 @default.
• W4323348318 doi "https://doi.org/10.1002/tox.23772" @default.
• W4323348318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36880448" @default.
• W4323348318 hasPublicationYear "2023" @default.
• W4323348318 type Work @default.
• W4323348318 citedByCount "0" @default.
• W4323348318 crossrefType "journal-article" @default.
• W4323348318 hasAuthorship W4323348318A5005526871 @default.
• W4323348318 hasAuthorship W4323348318A5018813034 @default.
• W4323348318 hasAuthorship W4323348318A5024406928 @default.
• W4323348318 hasAuthorship W4323348318A5032402772 @default.
• W4323348318 hasAuthorship W4323348318A5041402182 @default.
• W4323348318 hasAuthorship W4323348318A5055848895 @default.
• W4323348318 hasAuthorship W4323348318A5065852183 @default.
• W4323348318 hasAuthorship W4323348318A5088551350 @default.
• W4323348318 hasConcept C153911025 @default.
• W4323348318 hasConcept C164027704 @default.
• W4323348318 hasConcept C170493617 @default.
• W4323348318 hasConcept C17991360 @default.
• W4323348318 hasConcept C185592680 @default.
• W4323348318 hasConcept C190283241 @default.
• W4323348318 hasConcept C202751555 @default.
• W4323348318 hasConcept C203014093 @default.
• W4323348318 hasConcept C2776070231 @default.
• W4323348318 hasConcept C2776914184 @default.
• W4323348318 hasConcept C2777209026 @default.
• W4323348318 hasConcept C2779244956 @default.
• W4323348318 hasConcept C48349386 @default.
• W4323348318 hasConcept C55493867 @default.
• W4323348318 hasConcept C62478195 @default.
• W4323348318 hasConcept C86803240 @default.
• W4323348318 hasConcept C95444343 @default.
• W4323348318 hasConceptScore W4323348318C153911025 @default.
• W4323348318 hasConceptScore W4323348318C164027704 @default.
• W4323348318 hasConceptScore W4323348318C170493617 @default.
• W4323348318 hasConceptScore W4323348318C17991360 @default.
• W4323348318 hasConceptScore W4323348318C185592680 @default.
• W4323348318 hasConceptScore W4323348318C190283241 @default.
• W4323348318 hasConceptScore W4323348318C202751555 @default.
• W4323348318 hasConceptScore W4323348318C203014093 @default.
• W4323348318 hasConceptScore W4323348318C2776070231 @default.
• W4323348318 hasConceptScore W4323348318C2776914184 @default.
• W4323348318 hasConceptScore W4323348318C2777209026 @default.
• W4323348318 hasConceptScore W4323348318C2779244956 @default.
• W4323348318 hasConceptScore W4323348318C48349386 @default.

• next