FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323348634> ?p ?o ?g. }

• W4323348634 endingPage "e0281911" @default.
• W4323348634 startingPage "e0281911" @default.
• W4323348634 abstract "The objective of this study was to determine if locally delivered FK506 could prevent allogeneic nerve graft rejection long enough to allow axon regeneration to pass through the nerve graft. An 8mm mouse sciatic nerve gap injury repaired with a nerve allograft was used to assess the effectiveness of local FK506 immunosuppressive therapy. FK506-loaded poly(lactide-co-caprolactone) nerve conduits were used to provide sustained local FK506 delivery to nerve allografts. Continuous and temporary systemic FK506 therapy to nerve allografts, and autograft repair were used as control groups. Serial assessment of inflammatory cell and CD4+ cell infiltration into the nerve graft tissue was performed to characterize the immune response over time. Nerve regeneration and functional recovery was serially assessed by nerve histomorphometry, gastrocnemius muscle mass recovery, and the ladder rung skilled locomotion assay. At the end of the study, week 16, all the groups had similar levels of inflammatory cell infiltration. The local FK506 and continuous systemic FK506 groups had similar levels of CD4+ cell infiltration, however, it was significantly greater than the autograft control. In terms of nerve histmorphometry, the local FK506 and continunous systemic FK506 groups had similar amounts of myelinated axons, although they were significantly lower than the autograft and temporary systemic FK506 group. The autograft had significantly greater muscle mass recovery than all the other groups. In the ladder rung assay, the autograft, local FK506, and continuous systemic FK506 had similar levels of skilled locomotion performance, whereas the temporary systemic FK506 group had significanty better performance than all the other groups. The results of this study suggest that local delivery of FK506 can provide comparable immunosuppression and nerve regeneration outcomes as systemically delivered FK506." @default.
• W4323348634 created "2023-03-08" @default.
• W4323348634 creator A5004823813 @default.
• W4323348634 creator A5013340247 @default.
• W4323348634 creator A5015466897 @default.
• W4323348634 creator A5019679217 @default.
• W4323348634 creator A5041457976 @default.
• W4323348634 creator A5048127846 @default.
• W4323348634 creator A5053202084 @default.
• W4323348634 creator A5066534077 @default.
• W4323348634 creator A5090626475 @default.
• W4323348634 date "2023-03-07" @default.
• W4323348634 modified "2023-09-30" @default.
• W4323348634 title "Local delivery of FK506 to a nerve allograft is comparable to systemic delivery at suppressing allogeneic graft rejection" @default.
• W4323348634 cites W11396428 @default.
• W4323348634 cites W1554773849 @default.
• W4323348634 cites W1716040058 @default.
• W4323348634 cites W174477127 @default.
• W4323348634 cites W1784352764 @default.
• W4323348634 cites W1815678088 @default.
• W4323348634 cites W1856059914 @default.
• W4323348634 cites W1935201742 @default.
• W4323348634 cites W1962739656 @default.
• W4323348634 cites W1965431554 @default.
• W4323348634 cites W1970376540 @default.
• W4323348634 cites W1973705229 @default.
• W4323348634 cites W1975585602 @default.
• W4323348634 cites W1978910887 @default.
• W4323348634 cites W1980969134 @default.
• W4323348634 cites W1985965749 @default.
• W4323348634 cites W1994072220 @default.
• W4323348634 cites W1999361516 @default.
• W4323348634 cites W2000787219 @default.
• W4323348634 cites W2001555416 @default.
• W4323348634 cites W2018117162 @default.
• W4323348634 cites W2021137320 @default.
• W4323348634 cites W2022308075 @default.
• W4323348634 cites W2038358555 @default.
• W4323348634 cites W2040320961 @default.
• W4323348634 cites W2044476979 @default.
• W4323348634 cites W2045315526 @default.
• W4323348634 cites W2046869627 @default.
• W4323348634 cites W2048683475 @default.
• W4323348634 cites W2055222360 @default.
• W4323348634 cites W2058019895 @default.
• W4323348634 cites W2059720153 @default.
• W4323348634 cites W2065123875 @default.
• W4323348634 cites W2065617830 @default.
• W4323348634 cites W2068068235 @default.
• W4323348634 cites W2084402494 @default.
• W4323348634 cites W2087048035 @default.
• W4323348634 cites W2093076255 @default.
• W4323348634 cites W2093554010 @default.
• W4323348634 cites W2094192363 @default.
• W4323348634 cites W2094893926 @default.
• W4323348634 cites W2116356198 @default.
• W4323348634 cites W2120002445 @default.
• W4323348634 cites W2121741247 @default.
• W4323348634 cites W2142254746 @default.
• W4323348634 cites W2152524281 @default.
• W4323348634 cites W2338713638 @default.
• W4323348634 cites W2415312862 @default.
• W4323348634 cites W2417970061 @default.
• W4323348634 cites W2420206733 @default.
• W4323348634 cites W2466620019 @default.
• W4323348634 cites W2516844183 @default.
• W4323348634 cites W2589502365 @default.
• W4323348634 cites W2803365850 @default.
• W4323348634 cites W2883925980 @default.
• W4323348634 cites W2885691539 @default.
• W4323348634 cites W2943907511 @default.
• W4323348634 cites W2967247899 @default.
• W4323348634 cites W2999283345 @default.
• W4323348634 cites W3011463007 @default.
• W4323348634 cites W3020927102 @default.
• W4323348634 cites W3045820340 @default.
• W4323348634 cites W3134928792 @default.
• W4323348634 cites W4290415087 @default.
• W4323348634 doi "https://doi.org/10.1371/journal.pone.0281911" @default.
• W4323348634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36881592" @default.
• W4323348634 hasPublicationYear "2023" @default.
• W4323348634 type Work @default.
• W4323348634 citedByCount "0" @default.
• W4323348634 crossrefType "journal-article" @default.
• W4323348634 hasAuthorship W4323348634A5004823813 @default.
• W4323348634 hasAuthorship W4323348634A5013340247 @default.
• W4323348634 hasAuthorship W4323348634A5015466897 @default.
• W4323348634 hasAuthorship W4323348634A5019679217 @default.
• W4323348634 hasAuthorship W4323348634A5041457976 @default.
• W4323348634 hasAuthorship W4323348634A5048127846 @default.
• W4323348634 hasAuthorship W4323348634A5053202084 @default.
• W4323348634 hasAuthorship W4323348634A5066534077 @default.
• W4323348634 hasAuthorship W4323348634A5090626475 @default.
• W4323348634 hasBestOaLocation W43233486341 @default.
• W4323348634 hasConcept C105702510 @default.
• W4323348634 hasConcept C121332964 @default.
• W4323348634 hasConcept C141071460 @default.
• W4323348634 hasConcept C142724271 @default.

• next