Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323349799> ?p ?o ?g. }
- W4323349799 endingPage "1293" @default.
- W4323349799 startingPage "1284" @default.
- W4323349799 abstract "Age-related cognitive changes can be influenced by both brain maintenance (BM), which refers to the relative absence over time of changes in neural resources or neuropathologic changes, and cognitive reserve (CR), which encompasses brain processes that allow for better-than-expected behavioral performance given the degree of life-course-related brain changes. This study evaluated the effects of age, BM, and CR on longitudinal changes over 2 visits, 5 years apart, in 3 cognitive abilities that capture most of age-related variability.Participants included 254 healthy adults aged 20-80 years at recruitment. Potential BM was estimated using whole-brain cortical thickness and white matter mean diffusivity at both visits. Education and intelligence quotient (IQ; estimated with American National Adult Reading Test) were tested as moderating factors for cognitive changes in the 3 cognitive abilities.Consistent with BM-after accounting for age, sex, and baseline performance-individual differences in the preservation of mean diffusivity and cortical thickness were independently associated with relative preservation in the 3 abilities. Consistent with CR-after accounting for age, sex, baseline performance, and structural brain changes-higher IQ, but not education, was associated with reduced 5-year decline in reasoning (β = 0.387, p = .002), and education was associated with reduced decline in speed (β = 0.237, p = .039).These results demonstrate that both CR and BM can moderate cognitive changes in healthy aging and that the 2 mechanisms can make differential contributions to preserved cognition." @default.
- W4323349799 created "2023-03-08" @default.
- W4323349799 creator A5007221196 @default.
- W4323349799 creator A5012511802 @default.
- W4323349799 creator A5024123220 @default.
- W4323349799 creator A5032025339 @default.
- W4323349799 creator A5039953387 @default.
- W4323349799 creator A5042497043 @default.
- W4323349799 creator A5049228057 @default.
- W4323349799 creator A5066286613 @default.
- W4323349799 creator A5069689789 @default.
- W4323349799 creator A5079122936 @default.
- W4323349799 date "2023-03-07" @default.
- W4323349799 modified "2023-10-16" @default.
- W4323349799 title "Effects of Brain Maintenance and Cognitive Reserve on Age-Related Decline in Three Cognitive Abilities" @default.
- W4323349799 cites W1054918909 @default.
- W4323349799 cites W1450241149 @default.
- W4323349799 cites W1951284594 @default.
- W4323349799 cites W1968961315 @default.
- W4323349799 cites W1972195252 @default.
- W4323349799 cites W1973531657 @default.
- W4323349799 cites W1986685326 @default.
- W4323349799 cites W1993526839 @default.
- W4323349799 cites W2001851338 @default.
- W4323349799 cites W2028058169 @default.
- W4323349799 cites W2094871776 @default.
- W4323349799 cites W2107551763 @default.
- W4323349799 cites W2127490257 @default.
- W4323349799 cites W2128291848 @default.
- W4323349799 cites W2144084946 @default.
- W4323349799 cites W2144907160 @default.
- W4323349799 cites W2145336227 @default.
- W4323349799 cites W2158401065 @default.
- W4323349799 cites W2168922851 @default.
- W4323349799 cites W2169253949 @default.
- W4323349799 cites W2221276418 @default.
- W4323349799 cites W2464050582 @default.
- W4323349799 cites W2471747406 @default.
- W4323349799 cites W2485373762 @default.
- W4323349799 cites W2560045881 @default.
- W4323349799 cites W2755307222 @default.
- W4323349799 cites W2782431358 @default.
- W4323349799 cites W2803347851 @default.
- W4323349799 cites W2883359435 @default.
- W4323349799 cites W2884470693 @default.
- W4323349799 cites W2889677374 @default.
- W4323349799 cites W2892013400 @default.
- W4323349799 cites W2942192867 @default.
- W4323349799 cites W2950098267 @default.
- W4323349799 cites W2951856257 @default.
- W4323349799 cites W2966360417 @default.
- W4323349799 cites W2970396632 @default.
- W4323349799 cites W2992862671 @default.
- W4323349799 cites W3047728892 @default.
- W4323349799 cites W3124620008 @default.
- W4323349799 cites W3132792208 @default.
- W4323349799 cites W3182720410 @default.
- W4323349799 cites W4247251590 @default.
- W4323349799 cites W4311902677 @default.
- W4323349799 doi "https://doi.org/10.1093/geronb/gbad044" @default.
- W4323349799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36882044" @default.
- W4323349799 hasPublicationYear "2023" @default.
- W4323349799 type Work @default.
- W4323349799 citedByCount "1" @default.
- W4323349799 crossrefType "journal-article" @default.
- W4323349799 hasAuthorship W4323349799A5007221196 @default.
- W4323349799 hasAuthorship W4323349799A5012511802 @default.
- W4323349799 hasAuthorship W4323349799A5024123220 @default.
- W4323349799 hasAuthorship W4323349799A5032025339 @default.
- W4323349799 hasAuthorship W4323349799A5039953387 @default.
- W4323349799 hasAuthorship W4323349799A5042497043 @default.
- W4323349799 hasAuthorship W4323349799A5049228057 @default.
- W4323349799 hasAuthorship W4323349799A5066286613 @default.
- W4323349799 hasAuthorship W4323349799A5069689789 @default.
- W4323349799 hasAuthorship W4323349799A5079122936 @default.
- W4323349799 hasConcept C126322002 @default.
- W4323349799 hasConcept C126838900 @default.
- W4323349799 hasConcept C138496976 @default.
- W4323349799 hasConcept C143409427 @default.
- W4323349799 hasConcept C15744967 @default.
- W4323349799 hasConcept C166047926 @default.
- W4323349799 hasConcept C169760540 @default.
- W4323349799 hasConcept C169900460 @default.
- W4323349799 hasConcept C185711340 @default.
- W4323349799 hasConcept C2779134260 @default.
- W4323349799 hasConcept C2779483572 @default.
- W4323349799 hasConcept C2984863031 @default.
- W4323349799 hasConcept C2984915365 @default.
- W4323349799 hasConcept C2993665655 @default.
- W4323349799 hasConcept C548259974 @default.
- W4323349799 hasConcept C6057870 @default.
- W4323349799 hasConcept C65835030 @default.
- W4323349799 hasConcept C67739388 @default.
- W4323349799 hasConcept C71924100 @default.
- W4323349799 hasConcept C74909509 @default.
- W4323349799 hasConceptScore W4323349799C126322002 @default.
- W4323349799 hasConceptScore W4323349799C126838900 @default.
- W4323349799 hasConceptScore W4323349799C138496976 @default.