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- W4323350820 abstract "Abstract Background: Viral encephalitis increases later-life risk of Alzheimer’s disease (AD) by a factor of 31. Methods: To further evaluate this finding, we examined the relationship of West Nile virus (WNV) to Alzheimer’s disease in 50 US states. In addition, we performed a genome wide association study (GWAS) of viral encephalitis cases in UK Biobank (UKBB) to see if any encephalitis genes might be related to AD. Results: WNV was significantly associated with deaths from Alzheimer’s disease in 50 US states (r = 0.806, p < 0.001). One gene, RORB-AS1, was most significantly related on GWAS to viral encephalitis. RORB-AS1 (RORB Antisense RNA 1) is an RNA gene. Diseases associated with RORB-AS1 include childhood epilepsy and idiopathic generalized epilepsy. The closely related RORB (Related Orphan Receptor B) is a marker of selectively AD vulnerable excitatory neurons in the entorhinal cortex; these neurons are depleted and susceptible to neurofibrillary inclusions during AD progression. Conclusion: data presented here confirm the association of viral encephalitis with AD and suggest that WNV infection is a significant AD risk factor. A human WNV vaccine could reduce Alzheimer’s disease morbidity and mortality. In addition, GWAS suggests that the gene RORB, an important AD vulnerability factor, is significantly related to viral encephalitis." @default.
- W4323350820 created "2023-03-08" @default.
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- W4323350820 date "2023-03-07" @default.
- W4323350820 modified "2023-10-16" @default.
- W4323350820 title "RORB, an Alzheimer’s disease susceptibility gene, is associated with viral encephalitis, an Alzheimer’s disease risk factor" @default.
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- W4323350820 doi "https://doi.org/10.21203/rs.3.rs-2661273/v1" @default.
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