Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323352076> ?p ?o ?g. }
- W4323352076 abstract "The common Fc receptor γ (FcRγ) chain is a signaling subunit common to several immune receptors, but cellular responses induced by FcRγ-coupled receptors are diverse. We investigated the mechanisms by which FcRγ generates divergent signals when coupled to Dectin-2 and Mincle, structurally similar C-type lectin receptors that induce the release of different cytokines from dendritic cells. Chronological tracing of transcriptomic and epigenetic changes upon stimulation revealed that Dectin-2 induced early and strong signaling, whereas Mincle-mediated signaling was delayed, which reflects their expression patterns. Generation of early and strong FcRγ-Syk signaling by engineered chimeric receptors was sufficient to recapitulate a Dectin-2-like gene expression profile. Early Syk signaling selectively stimulated the activity of the calcium ion-activated transcription factor NFAT, which rapidly altered the chromatin status and transcription of the Il2 gene. In contrast, proinflammatory cytokines, such as TNF, were induced regardless of FcRγ signaling kinetics. These results suggest that the strength and timing of FcRγ-Syk signaling can alter the quality of cellular responses through kinetics-sensing signaling machineries." @default.
- W4323352076 created "2023-03-08" @default.
- W4323352076 creator A5001656277 @default.
- W4323352076 creator A5027875373 @default.
- W4323352076 creator A5059152037 @default.
- W4323352076 date "2023-03-07" @default.
- W4323352076 modified "2023-09-26" @default.
- W4323352076 title "The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells" @default.
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- W4323352076 cites W1604635829 @default.
- W4323352076 cites W1645244049 @default.
- W4323352076 cites W1755849265 @default.
- W4323352076 cites W1779160407 @default.
- W4323352076 cites W1970252429 @default.
- W4323352076 cites W1976257926 @default.
- W4323352076 cites W1976670151 @default.
- W4323352076 cites W1977917052 @default.
- W4323352076 cites W1980754944 @default.
- W4323352076 cites W1985579610 @default.
- W4323352076 cites W1988248740 @default.
- W4323352076 cites W1988820663 @default.
- W4323352076 cites W1994894837 @default.
- W4323352076 cites W1995819749 @default.
- W4323352076 cites W1996655452 @default.
- W4323352076 cites W1998415250 @default.
- W4323352076 cites W1998435868 @default.
- W4323352076 cites W2016155378 @default.
- W4323352076 cites W2017341404 @default.
- W4323352076 cites W2018775174 @default.
- W4323352076 cites W2020308822 @default.
- W4323352076 cites W2022480304 @default.
- W4323352076 cites W2027562913 @default.
- W4323352076 cites W2032125984 @default.
- W4323352076 cites W2035011417 @default.
- W4323352076 cites W2035096151 @default.
- W4323352076 cites W2036780390 @default.
- W4323352076 cites W2041308303 @default.
- W4323352076 cites W2044153851 @default.
- W4323352076 cites W2048162805 @default.
- W4323352076 cites W2056597149 @default.
- W4323352076 cites W2061725286 @default.
- W4323352076 cites W2065429310 @default.
- W4323352076 cites W2065681262 @default.
- W4323352076 cites W2070551124 @default.
- W4323352076 cites W2070597700 @default.
- W4323352076 cites W2071423255 @default.
- W4323352076 cites W2074059194 @default.
- W4323352076 cites W2074795280 @default.
- W4323352076 cites W2075901113 @default.
- W4323352076 cites W2083380661 @default.
- W4323352076 cites W2086105638 @default.
- W4323352076 cites W2094652659 @default.
- W4323352076 cites W2112490815 @default.
- W4323352076 cites W2114675972 @default.
- W4323352076 cites W2125278679 @default.
- W4323352076 cites W2129374849 @default.
- W4323352076 cites W2136437831 @default.
- W4323352076 cites W2143300196 @default.
- W4323352076 cites W2148215656 @default.
- W4323352076 cites W2150317682 @default.
- W4323352076 cites W2152621712 @default.
- W4323352076 cites W2156861171 @default.
- W4323352076 cites W2166529715 @default.
- W4323352076 cites W2169211336 @default.
- W4323352076 cites W2239399748 @default.
- W4323352076 cites W2327515900 @default.
- W4323352076 cites W2335984750 @default.
- W4323352076 cites W2338753015 @default.
- W4323352076 cites W2530405675 @default.
- W4323352076 cites W2552391721 @default.
- W4323352076 cites W2556744489 @default.
- W4323352076 cites W2570518751 @default.
- W4323352076 cites W2591978212 @default.
- W4323352076 cites W2595584585 @default.
- W4323352076 cites W2604816124 @default.
- W4323352076 cites W2619991421 @default.
- W4323352076 cites W2790628975 @default.
- W4323352076 cites W2792588868 @default.
- W4323352076 cites W2800148661 @default.
- W4323352076 cites W2890141820 @default.
- W4323352076 cites W2900310474 @default.
- W4323352076 cites W2942049643 @default.
- W4323352076 cites W2944599913 @default.
- W4323352076 cites W2977451481 @default.
- W4323352076 cites W2980210077 @default.
- W4323352076 cites W3017249809 @default.
- W4323352076 cites W3049194445 @default.
- W4323352076 cites W3088221604 @default.
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- W4323352076 doi "https://doi.org/10.1126/scisignal.abn9909" @default.
- W4323352076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36881655" @default.
- W4323352076 hasPublicationYear "2023" @default.
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