Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323353721> ?p ?o ?g. }
- W4323353721 abstract "Identification of antisynthetase syndrome (ASS) could be challenging due to inaccessibility and technical difficulty of the serology test for the less common non-Jo-1 antibodies. This study aimed to describe ASS antibody-specific myopathology and evaluate the diagnostic utility of myofiber HLA-DR expression. We reviewed 212 ASS muscle biopsies and compared myopathologic features among subtypes. Additionally, we compared their HLA-DR staining pattern with 602 non-ASS myositis and 140 genetically confirmed myopathies known to have an inflammatory component. We used t-test and Fisher's exact for comparisons and used sensitivity, specificity, positive and negative predictive values to assess the utility of HLA-DR expression for ASS diagnosis. RNAseq performed from a subset of myositis cases and histologically normal muscle biopsies was used to evaluate interferon (IFN)-signaling pathway-related genes. Anti-OJ ASS showed prominent myopathology with higher scores in muscle fiber (4.6 ± 2.0 vs. 2.8 ± 1.8, p = 0.001) and inflammatory domains (6.8 ± 3.2 vs. 4.5 ± 2.9, p = 0.006) than non-OJ ASS. HLA-DR expression and IFN-γ-related genes upregulation were prominent in ASS and inclusion body myositis (IBM). When dermatomyositis and IBM were excluded, HLA-DR expression was 95.4% specific and 61.2% sensitive for ASS with a positive predictive value of 85.9% and a negative predictive value of 84.2%; perifascicular HLA-DR pattern is common in anti-Jo-1 ASS than non-Jo-1 ASS (63.1% vs. 5.1%, p < 0.0001). In the appropriate clinicopathological context, myofiber HLA-DR expression help support ASS diagnosis. The presence of HLA-DR expression suggests involvement of IFN-γ in the pathogenesis of ASS, though the detailed mechanisms have yet to be elucidated." @default.
- W4323353721 created "2023-03-08" @default.
- W4323353721 creator A5004908859 @default.
- W4323353721 creator A5017968003 @default.
- W4323353721 creator A5030937450 @default.
- W4323353721 creator A5040895870 @default.
- W4323353721 creator A5061142650 @default.
- W4323353721 creator A5069310256 @default.
- W4323353721 creator A5069628033 @default.
- W4323353721 creator A5079988161 @default.
- W4323353721 creator A5081843080 @default.
- W4323353721 creator A5085486382 @default.
- W4323353721 date "2023-03-07" @default.
- W4323353721 modified "2023-09-26" @default.
- W4323353721 title "Muscle pathology of antisynthetase syndrome according to antibody subtypes" @default.
- W4323353721 cites W1974946256 @default.
- W4323353721 cites W1979405663 @default.
- W4323353721 cites W1991216587 @default.
- W4323353721 cites W2004089161 @default.
- W4323353721 cites W2022558733 @default.
- W4323353721 cites W2028983972 @default.
- W4323353721 cites W2044473992 @default.
- W4323353721 cites W2097831806 @default.
- W4323353721 cites W2134758619 @default.
- W4323353721 cites W2134810534 @default.
- W4323353721 cites W2139544990 @default.
- W4323353721 cites W2166113386 @default.
- W4323353721 cites W2170575807 @default.
- W4323353721 cites W2174731795 @default.
- W4323353721 cites W2179438025 @default.
- W4323353721 cites W2297259461 @default.
- W4323353721 cites W2314311014 @default.
- W4323353721 cites W2325685715 @default.
- W4323353721 cites W2339882081 @default.
- W4323353721 cites W2406250479 @default.
- W4323353721 cites W2412354948 @default.
- W4323353721 cites W2511824754 @default.
- W4323353721 cites W2564946112 @default.
- W4323353721 cites W2592811885 @default.
- W4323353721 cites W2594723614 @default.
- W4323353721 cites W2623592054 @default.
- W4323353721 cites W2765714778 @default.
- W4323353721 cites W2792701170 @default.
- W4323353721 cites W2884773213 @default.
- W4323353721 cites W2891506196 @default.
- W4323353721 cites W2897468238 @default.
- W4323353721 cites W2938036544 @default.
- W4323353721 cites W2939992709 @default.
- W4323353721 cites W2942622127 @default.
- W4323353721 cites W2969640262 @default.
- W4323353721 cites W2985448772 @default.
- W4323353721 cites W3005580320 @default.
- W4323353721 cites W3015648569 @default.
- W4323353721 cites W3030255732 @default.
- W4323353721 cites W3031200339 @default.
- W4323353721 cites W3047311784 @default.
- W4323353721 cites W3080907109 @default.
- W4323353721 cites W3110170859 @default.
- W4323353721 cites W3168931634 @default.
- W4323353721 cites W3173195791 @default.
- W4323353721 cites W3188927724 @default.
- W4323353721 cites W4206020284 @default.
- W4323353721 cites W4212919282 @default.
- W4323353721 cites W4214568596 @default.
- W4323353721 cites W4226526432 @default.
- W4323353721 cites W4280574385 @default.
- W4323353721 cites W4281478899 @default.
- W4323353721 cites W4323353721 @default.
- W4323353721 doi "https://doi.org/10.1111/bpa.13155" @default.
- W4323353721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36882048" @default.
- W4323353721 hasPublicationYear "2023" @default.
- W4323353721 type Work @default.
- W4323353721 citedByCount "2" @default.
- W4323353721 countsByYear W43233537212023 @default.
- W4323353721 crossrefType "journal-article" @default.
- W4323353721 hasAuthorship W4323353721A5004908859 @default.
- W4323353721 hasAuthorship W4323353721A5017968003 @default.
- W4323353721 hasAuthorship W4323353721A5030937450 @default.
- W4323353721 hasAuthorship W4323353721A5040895870 @default.
- W4323353721 hasAuthorship W4323353721A5061142650 @default.
- W4323353721 hasAuthorship W4323353721A5069310256 @default.
- W4323353721 hasAuthorship W4323353721A5069628033 @default.
- W4323353721 hasAuthorship W4323353721A5079988161 @default.
- W4323353721 hasAuthorship W4323353721A5081843080 @default.
- W4323353721 hasAuthorship W4323353721A5085486382 @default.
- W4323353721 hasBestOaLocation W43233537211 @default.
- W4323353721 hasConcept C142724271 @default.
- W4323353721 hasConcept C159654299 @default.
- W4323353721 hasConcept C163764329 @default.
- W4323353721 hasConcept C203014093 @default.
- W4323353721 hasConcept C204232928 @default.
- W4323353721 hasConcept C2777327098 @default.
- W4323353721 hasConcept C2778751314 @default.
- W4323353721 hasConcept C2779017958 @default.
- W4323353721 hasConcept C2780181341 @default.
- W4323353721 hasConcept C2781232998 @default.
- W4323353721 hasConcept C71924100 @default.
- W4323353721 hasConceptScore W4323353721C142724271 @default.
- W4323353721 hasConceptScore W4323353721C159654299 @default.
- W4323353721 hasConceptScore W4323353721C163764329 @default.