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- W4323353854 abstract "In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia and astrocytes is an innate immune response to counteract stressful and dangerous insults. One of the most important and best characterized players in the neuroinflammatory response is the NLRP3 inflammasome, a multiproteic complex composed by NOD-like receptor family Pyrin domain containing 3 (NLRP3), apoptosis-associated speck–like protein (ASC) and pro-caspase-1. Different stimuli mediate NLRP3 activation, resulting in the NLRP3 inflammasome assembly and the pro-inflammatory cytokine (IL-1β and IL-18) maturation and secretion. The persistent and uncontrolled NLRP3 inflammasome activation has a leading role during the pathophysiology of neuroinflammation in age-related neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). The neurotransmitter dopamine (DA) is one of the players that negatively modulate NLRP3 inflammasome activation through DA receptors expressed in both microglia and astrocytes. This review summarizes recent findings linking the role of DA in the modulation of NLRP3-mediated neuroinflammation in PD and AD, where early deficits of the dopaminergic system are well characterized. Highlighting the relationship between DA, its glial receptors and the NLRP3-mediated neuroinflammation can provide insights to novel diagnostic strategies in early disease phases and new pharmacological tools to delay the progression of these diseases." @default.
- W4323353854 created "2023-03-08" @default.
- W4323353854 creator A5015408473 @default.
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- W4323353854 creator A5017540647 @default.
- W4323353854 creator A5032325256 @default.
- W4323353854 creator A5055450619 @default.
- W4323353854 date "2023-06-01" @default.
- W4323353854 modified "2023-10-10" @default.
- W4323353854 title "The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases" @default.
- W4323353854 cites W1416972414 @default.
- W4323353854 cites W1480524175 @default.
- W4323353854 cites W1537669972 @default.
- W4323353854 cites W1539730987 @default.
- W4323353854 cites W1561041814 @default.
- W4323353854 cites W1579609692 @default.
- W4323353854 cites W1606236576 @default.
- W4323353854 cites W1801353699 @default.
- W4323353854 cites W1818938823 @default.
- W4323353854 cites W1824827932 @default.
- W4323353854 cites W1864325817 @default.
- W4323353854 cites W1963666458 @default.
- W4323353854 cites W1964041350 @default.
- W4323353854 cites W1968467234 @default.
- W4323353854 cites W1969619562 @default.
- W4323353854 cites W1973477241 @default.
- W4323353854 cites W1980789245 @default.
- W4323353854 cites W1982669993 @default.
- W4323353854 cites W1983892290 @default.
- W4323353854 cites W1985001669 @default.
- W4323353854 cites W1985970823 @default.
- W4323353854 cites W1987329700 @default.
- W4323353854 cites W1991165501 @default.
- W4323353854 cites W1992919799 @default.
- W4323353854 cites W1993976394 @default.
- W4323353854 cites W2001244796 @default.
- W4323353854 cites W2004205580 @default.
- W4323353854 cites W2007747853 @default.
- W4323353854 cites W2008196551 @default.
- W4323353854 cites W2014602273 @default.
- W4323353854 cites W2015283405 @default.
- W4323353854 cites W2017814058 @default.
- W4323353854 cites W2021272772 @default.
- W4323353854 cites W2024975933 @default.
- W4323353854 cites W2028519649 @default.
- W4323353854 cites W2030205627 @default.
- W4323353854 cites W2035382111 @default.
- W4323353854 cites W2048512374 @default.
- W4323353854 cites W2054421268 @default.
- W4323353854 cites W2055487345 @default.
- W4323353854 cites W2059473240 @default.
- W4323353854 cites W2062305010 @default.
- W4323353854 cites W2063652053 @default.
- W4323353854 cites W2065126965 @default.
- W4323353854 cites W2067043938 @default.
- W4323353854 cites W2072074272 @default.
- W4323353854 cites W2075887668 @default.
- W4323353854 cites W2076992938 @default.
- W4323353854 cites W2080827095 @default.
- W4323353854 cites W2081294643 @default.
- W4323353854 cites W2082903897 @default.
- W4323353854 cites W2084158898 @default.
- W4323353854 cites W2084566588 @default.
- W4323353854 cites W2085424855 @default.
- W4323353854 cites W2088164523 @default.
- W4323353854 cites W2088359631 @default.
- W4323353854 cites W2090165838 @default.
- W4323353854 cites W2090187118 @default.
- W4323353854 cites W2091043188 @default.
- W4323353854 cites W2093271285 @default.
- W4323353854 cites W2094660330 @default.
- W4323353854 cites W2098142645 @default.
- W4323353854 cites W2100986512 @default.
- W4323353854 cites W2101667799 @default.
- W4323353854 cites W2102694854 @default.
- W4323353854 cites W2103037576 @default.
- W4323353854 cites W2105263387 @default.
- W4323353854 cites W2106492904 @default.
- W4323353854 cites W2108335346 @default.
- W4323353854 cites W2109759840 @default.
- W4323353854 cites W2109963281 @default.
- W4323353854 cites W2110811289 @default.
- W4323353854 cites W2111464898 @default.
- W4323353854 cites W2112880160 @default.
- W4323353854 cites W2117691576 @default.
- W4323353854 cites W2118403357 @default.
- W4323353854 cites W2119098586 @default.
- W4323353854 cites W2120815988 @default.
- W4323353854 cites W2120850024 @default.
- W4323353854 cites W2121007598 @default.
- W4323353854 cites W2121860798 @default.
- W4323353854 cites W2123640179 @default.
- W4323353854 cites W2124405216 @default.
- W4323353854 cites W2126384811 @default.
- W4323353854 cites W2128833728 @default.
- W4323353854 cites W2131909570 @default.
- W4323353854 cites W2132592261 @default.
- W4323353854 cites W2135376726 @default.