Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323355280> ?p ?o ?g. }
- W4323355280 abstract "Abstract The prognosis of high-grade gliomas, such as glioblastoma multiforme (GBM), is extremely poor due to the highly invasive nature of these aggressive cancers. Previous work has demonstrated that TNF-weak like factor (TWEAK) induction of the noncanonical NF-κB pathway increases the invasiveness of glioma cells in an NF-κB-inducing kinase (NIK)-dependent manner. While NIK activity is predominantly regulated at the posttranslational level, we show here that NIK ( MAP3K14 ) is upregulated at the transcriptional level in invading cell populations, with the highest expression observed in the most invasive cells. Glioma cells with high induction of NIK gene expression demonstrate characteristics of collective invasion, facilitating invasion of neighboring cells. Furthermore, we demonstrate that the E2F transcription factors E2F4 and E2F5 directly regulate NIK transcription and are required to promote glioma cell invasion in response to TWEAK. Overall, our findings demonstrate that transcriptional induction of NIK facilitates collective cell migration and invasion, thereby promoting glioma pathogenesis." @default.
- W4323355280 created "2023-03-08" @default.
- W4323355280 creator A5001255923 @default.
- W4323355280 creator A5035177932 @default.
- W4323355280 creator A5054145242 @default.
- W4323355280 creator A5084221679 @default.
- W4323355280 creator A5085548357 @default.
- W4323355280 date "2023-03-07" @default.
- W4323355280 modified "2023-10-16" @default.
- W4323355280 title "Transcriptional Induction of NF-kB-Inducing Kinase by E2F4/5 Facilitates Collective Invasion of Glioma Cells" @default.
- W4323355280 cites W1494520636 @default.
- W4323355280 cites W1973354681 @default.
- W4323355280 cites W1973901416 @default.
- W4323355280 cites W1998812648 @default.
- W4323355280 cites W2012069537 @default.
- W4323355280 cites W2012376126 @default.
- W4323355280 cites W2012615147 @default.
- W4323355280 cites W2026858875 @default.
- W4323355280 cites W2036981062 @default.
- W4323355280 cites W2042361125 @default.
- W4323355280 cites W2049226990 @default.
- W4323355280 cites W2054003628 @default.
- W4323355280 cites W2058874522 @default.
- W4323355280 cites W2096482691 @default.
- W4323355280 cites W2128130529 @default.
- W4323355280 cites W2129269004 @default.
- W4323355280 cites W2137401479 @default.
- W4323355280 cites W2253982573 @default.
- W4323355280 cites W2298525657 @default.
- W4323355280 cites W2414949501 @default.
- W4323355280 cites W2461997959 @default.
- W4323355280 cites W2470164054 @default.
- W4323355280 cites W2552838557 @default.
- W4323355280 cites W2753301411 @default.
- W4323355280 cites W2789604475 @default.
- W4323355280 cites W2796336431 @default.
- W4323355280 cites W2805776445 @default.
- W4323355280 cites W2894279258 @default.
- W4323355280 cites W2898343493 @default.
- W4323355280 cites W2900444338 @default.
- W4323355280 cites W2922699848 @default.
- W4323355280 cites W2970613241 @default.
- W4323355280 cites W2982691328 @default.
- W4323355280 cites W2991611852 @default.
- W4323355280 cites W2997878069 @default.
- W4323355280 cites W3004165448 @default.
- W4323355280 cites W3103691049 @default.
- W4323355280 cites W3177937846 @default.
- W4323355280 cites W4291004591 @default.
- W4323355280 cites W4296051614 @default.
- W4323355280 doi "https://doi.org/10.21203/rs.3.rs-2622363/v1" @default.
- W4323355280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36945490" @default.
- W4323355280 hasPublicationYear "2023" @default.
- W4323355280 type Work @default.
- W4323355280 citedByCount "1" @default.
- W4323355280 countsByYear W43233552802023 @default.
- W4323355280 crossrefType "posted-content" @default.
- W4323355280 hasAuthorship W4323355280A5001255923 @default.
- W4323355280 hasAuthorship W4323355280A5035177932 @default.
- W4323355280 hasAuthorship W4323355280A5054145242 @default.
- W4323355280 hasAuthorship W4323355280A5084221679 @default.
- W4323355280 hasAuthorship W4323355280A5085548357 @default.
- W4323355280 hasBestOaLocation W43233552801 @default.
- W4323355280 hasConcept C104317684 @default.
- W4323355280 hasConcept C127561419 @default.
- W4323355280 hasConcept C138885662 @default.
- W4323355280 hasConcept C1491633281 @default.
- W4323355280 hasConcept C179926584 @default.
- W4323355280 hasConcept C184235292 @default.
- W4323355280 hasConcept C2777730290 @default.
- W4323355280 hasConcept C2778227246 @default.
- W4323355280 hasConcept C41895202 @default.
- W4323355280 hasConcept C502942594 @default.
- W4323355280 hasConcept C54355233 @default.
- W4323355280 hasConcept C62478195 @default.
- W4323355280 hasConcept C83258922 @default.
- W4323355280 hasConcept C86339819 @default.
- W4323355280 hasConcept C86803240 @default.
- W4323355280 hasConcept C95444343 @default.
- W4323355280 hasConceptScore W4323355280C104317684 @default.
- W4323355280 hasConceptScore W4323355280C127561419 @default.
- W4323355280 hasConceptScore W4323355280C138885662 @default.
- W4323355280 hasConceptScore W4323355280C1491633281 @default.
- W4323355280 hasConceptScore W4323355280C179926584 @default.
- W4323355280 hasConceptScore W4323355280C184235292 @default.
- W4323355280 hasConceptScore W4323355280C2777730290 @default.
- W4323355280 hasConceptScore W4323355280C2778227246 @default.
- W4323355280 hasConceptScore W4323355280C41895202 @default.
- W4323355280 hasConceptScore W4323355280C502942594 @default.
- W4323355280 hasConceptScore W4323355280C54355233 @default.
- W4323355280 hasConceptScore W4323355280C62478195 @default.
- W4323355280 hasConceptScore W4323355280C83258922 @default.
- W4323355280 hasConceptScore W4323355280C86339819 @default.
- W4323355280 hasConceptScore W4323355280C86803240 @default.
- W4323355280 hasConceptScore W4323355280C95444343 @default.
- W4323355280 hasLocation W43233552801 @default.
- W4323355280 hasLocation W43233552802 @default.
- W4323355280 hasLocation W43233552803 @default.
- W4323355280 hasOpenAccess W4323355280 @default.
- W4323355280 hasPrimaryLocation W43233552801 @default.