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- W4323362806 abstract "Pancreatic ductal adenocarcinoma (PDAC) is rapidly becoming one of the leading causes of cancer-related deaths in the United States, and with its high mortality rate, there is a pressing need to develop sensitive and robust methods for detection. Exosomal biomarker panels provide a promising avenue for PDAC screening since exosomes are highly stable and easily harvested from body fluids. PDAC-associated miRNAs packaged within these exosomes could be used as diagnostic markers. We analyzed a series of 18 candidate miRNAs via RT-qPCR to identify the differentially expressed miRNAs (p < 0.05, t-test) between plasma exosomes harvested from PDAC patients and control patients. From this analysis, we propose a four-marker panel consisting of miR-93-5p, miR-339-3p, miR-425-5p, and miR-425-3p with an area under the curve (AUC) of the receiver operator characteristic curve (ROC) of 0.885 with a sensitivity of 80% and a specificity of 94.7%, which is comparable to the CA19-9 standard PDAC marker diagnostic." @default.
- W4323362806 created "2023-03-08" @default.
- W4323362806 creator A5048437530 @default.
- W4323362806 creator A5066565569 @default.
- W4323362806 date "2023-03-07" @default.
- W4323362806 modified "2023-09-29" @default.
- W4323362806 title "Exosomal miRNA Biomarker Panel for Pancreatic Ductal Adenocarcinoma Detection in Patient Plasma: A Pilot Study" @default.
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- W4323362806 doi "https://doi.org/10.3390/ijms24065081" @default.
- W4323362806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36982154" @default.
- W4323362806 hasPublicationYear "2023" @default.
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