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• W4323363112 abstract "Objectives To evaluate the efficacy of a single preoperative dose of S-ketamine for chronic post-surgical pain (CPSP) in patients undergoing video-assisted thoracoscopic surgical lung lesion resection (VATS). Design A prospective randomized double-blind controlled study. Setting Patients were enrolled from March 17, 2021 to November 18, 2021 at a single tertiary academic hospital. Participants Patients were 18-65 years of age and undergoing VATS. Interventions The experiment was divided into S-ketamine group (0.5 mg/kg intravenous injection before anesthesia induction) or placebo group (the same volume of normal saline). Measurements and Main Results The primary end point was the incidence of CPSP and its neuropathic component. The secondary end points included acute postoperative pain, the use of postoperative analgesics, anxiety and sleep quality scores, and the occurrence of adverse effects. There was no significant difference between the two groups in the incidence of CPSP, neuropathic pain, acute postoperative pain and postoperative use of analgesics. The sleep quality scores on the first postoperative day differed significantly between the groups (47.45 ± 27.58 vs. 52.97 ± 27.57, P = 0.049), but not the anxiety scores. In addition, the occurrence of adverse effects was similar between the two groups. Conclusions A single preoperative dose of S-ketamine in patients who underwent VATS had no significant impact on acute and chronic postoperative pain, as well the consumption of analgesics after surgery. A single preoperative dose of S-ketamine could improve the sleep on the first day after surgery, whereas it had no significant impact on anxiety level. Trial registration Registered in the Chinese Clinical Trial Registry (ChiCTR2100042140) on January 14th 2021." @default.
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• W4323363112 date "2023-08-01" @default.
• W4323363112 modified "2023-10-14" @default.
• W4323363112 title "A Single Preoperative Dose of S-Ketamine Has No Beneficial Effect on Chronic Postsurgical Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgical Lung Lesion Resection: A Prospective Randomized Controlled Study" @default.
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• W4323363112 doi "https://doi.org/10.1053/j.jvca.2023.02.046" @default.
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