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• W4323363122 endingPage "115649" @default.
• W4323363122 startingPage "115649" @default.
• W4323363122 abstract "Diets contain toxic chemical contaminants as well as essential nutrients, both of which influence the intrauterine environment for foetal growth. However, whether a high-quality diet that is nutritionally healthy also results in lower exposure to chemical contaminants is unknown.We examined associations between periconceptional maternal diet quality and circulating concentrations of heavy metals during pregnancy.Dietary intake over the year prior to the first trimester of pregnancy was assessed using a validated, self-administered food frequency questionnaire among 81,104 pregnant Japanese women who participated in the Japan Environment and Children's Study. Overall diet quality was determined using the Balanced Diet Score (BDS) based on the Japanese Food Guide Spinning Top, the Healthy Eating Index-2015 (HEI-2015), the Dietary Approaches to Stop Hypertension (DASH) score and the Mediterranean diet score (MDS). We measured whole-blood concentrations of mercury (Hg), lead (Pb) and cadmium (Cd) during the second or third trimester of pregnancy.After controlling for confounders, all diet quality scores were positively associated with blood Hg concentrations. By contrast, higher BDS, HEI-2015 and DASH scores were associated with lower concentrations of Pb and Cd. Although the MDS was positively associated with concentrations of Pb and Cd, when dairy products were classified as a beneficial (rather than detrimental) food component, these associations were attenuated.A high-quality diet may reduce exposure to Pb and Cd but not Hg. Further studies are required to determine the optimal balance between mercury exposure risk and nutritional benefits of high-quality diets prior to pregnancy." @default.
• W4323363122 created "2023-03-08" @default.
• W4323363122 creator A5013146465 @default.
• W4323363122 creator A5090447691 @default.
• W4323363122 date "2023-05-01" @default.
• W4323363122 modified "2023-10-02" @default.
• W4323363122 title "Periconceptional diet quality and its relation to blood heavy metal concentrations among pregnant women: The Japan environment and Children’s study" @default.
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• W4323363122 doi "https://doi.org/10.1016/j.envres.2023.115649" @default.
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