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- W4323364088 abstract "PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are significant in development and reproduction of organisms. Recently, emerging evidences have indicated that apart from the reproductive function, PIWI/piRNAs with abnormal expression, also involve greatly in varieties of human cancers. Moreover, human PIWI proteins are usually expressed only in germ cells and hardly in somatic cells, so the abnormal expression of PIWI proteins in different types of cancer offer a promising opportunity for precision medicine. In this review, we discussed current researches about the biogenesis of piRNA, its epigenetic regulatory mechanisms in human cancers, such as N6-methyladenosine (m6A) methylation, histone modifications, DNA methylation and RNA interference, providing novel insights into the markers for clinical diagnosis, treatment and prognosis in human cancers." @default.
- W4323364088 created "2023-03-08" @default.
- W4323364088 creator A5006833753 @default.
- W4323364088 creator A5014505099 @default.
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- W4323364088 creator A5040682142 @default.
- W4323364088 creator A5040850883 @default.
- W4323364088 creator A5059894090 @default.
- W4323364088 creator A5064409262 @default.
- W4323364088 creator A5071376212 @default.
- W4323364088 creator A5082396860 @default.
- W4323364088 date "2023-03-07" @default.
- W4323364088 modified "2023-10-14" @default.
- W4323364088 title "The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers" @default.
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