FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323535601> ?p ?o ?g. }

• W4323535601 abstract "Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, but in practice, they often secrete poorly. Here we show that designed hydrophobic interfaces that drive nanoparticle assembly are often predicted to form cryptic transmembrane domains, suggesting that interaction with the membrane insertion machinery could limit efficient secretion. We develop a general computational protocol, the Degreaser, to design away cryptic transmembrane domains without sacrificing protein stability. The retroactive application of the Degreaser to previously designed nanoparticle components and nanoparticles considerably improves secretion, and modular integration of the Degreaser into design pipelines results in new nanoparticles that secrete as robustly as naturally occurring protein assemblies. Both the Degreaser protocol and the nanoparticles we describe may be broadly useful in biotechnological applications." @default.
• W4323535601 created "2023-03-09" @default.
• W4323535601 creator A5003066216 @default.
• W4323535601 creator A5015415874 @default.
• W4323535601 creator A5016759610 @default.
• W4323535601 creator A5016851342 @default.
• W4323535601 creator A5019745674 @default.
• W4323535601 creator A5021476730 @default.
• W4323535601 creator A5038302116 @default.
• W4323535601 creator A5038502208 @default.
• W4323535601 creator A5038577052 @default.
• W4323535601 creator A5038946848 @default.
• W4323535601 creator A5042927815 @default.
• W4323535601 creator A5043923862 @default.
• W4323535601 creator A5046641635 @default.
• W4323535601 creator A5046648996 @default.
• W4323535601 creator A5052424919 @default.
• W4323535601 creator A5053192926 @default.
• W4323535601 creator A5055724082 @default.
• W4323535601 creator A5058576287 @default.
• W4323535601 creator A5067790213 @default.
• W4323535601 creator A5071359121 @default.
• W4323535601 creator A5075418102 @default.
• W4323535601 creator A5081264094 @default.
• W4323535601 creator A5082998619 @default.
• W4323535601 creator A5084801724 @default.
• W4323535601 creator A5084889915 @default.
• W4323535601 creator A5090099671 @default.
• W4323535601 date "2023-03-08" @default.
• W4323535601 modified "2023-10-16" @default.
• W4323535601 title "Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains" @default.
• W4323535601 cites W1915453701 @default.
• W4323535601 cites W1964275463 @default.
• W4323535601 cites W1990789777 @default.
• W4323535601 cites W1991858391 @default.
• W4323535601 cites W1996478334 @default.
• W4323535601 cites W2001931036 @default.
• W4323535601 cites W2002844537 @default.
• W4323535601 cites W2006225923 @default.
• W4323535601 cites W2015526636 @default.
• W4323535601 cites W2024191848 @default.
• W4323535601 cites W2025859600 @default.
• W4323535601 cites W2038605297 @default.
• W4323535601 cites W2044012108 @default.
• W4323535601 cites W2052937459 @default.
• W4323535601 cites W2056034415 @default.
• W4323535601 cites W2078988344 @default.
• W4323535601 cites W2093057097 @default.
• W4323535601 cites W2093343938 @default.
• W4323535601 cites W2094068725 @default.
• W4323535601 cites W2105267309 @default.
• W4323535601 cites W2113495611 @default.
• W4323535601 cites W2115687906 @default.
• W4323535601 cites W2118628900 @default.
• W4323535601 cites W2119710091 @default.
• W4323535601 cites W2119874960 @default.
• W4323535601 cites W2122550753 @default.
• W4323535601 cites W2132184418 @default.
• W4323535601 cites W2134238361 @default.
• W4323535601 cites W2140435480 @default.
• W4323535601 cites W2142796125 @default.
• W4323535601 cites W2143346248 @default.
• W4323535601 cites W2149283088 @default.
• W4323535601 cites W2152764495 @default.
• W4323535601 cites W2172319351 @default.
• W4323535601 cites W2201713963 @default.
• W4323535601 cites W2402070854 @default.
• W4323535601 cites W2433987067 @default.
• W4323535601 cites W2491008760 @default.
• W4323535601 cites W2519539312 @default.
• W4323535601 cites W2577723078 @default.
• W4323535601 cites W2750464792 @default.
• W4323535601 cites W2767258206 @default.
• W4323535601 cites W2773773416 @default.
• W4323535601 cites W2784051357 @default.
• W4323535601 cites W2800329064 @default.
• W4323535601 cites W2800755544 @default.
• W4323535601 cites W2884027472 @default.
• W4323535601 cites W2891841439 @default.
• W4323535601 cites W2908391177 @default.
• W4323535601 cites W2913212173 @default.
• W4323535601 cites W2914639442 @default.
• W4323535601 cites W2917928050 @default.
• W4323535601 cites W2921646015 @default.
• W4323535601 cites W2944245644 @default.
• W4323535601 cites W2949915773 @default.
• W4323535601 cites W2965830542 @default.
• W4323535601 cites W2990646888 @default.
• W4323535601 cites W3005859534 @default.
• W4323535601 cites W3007443568 @default.
• W4323535601 cites W3021975097 @default.
• W4323535601 cites W3044914269 @default.
• W4323535601 cites W3047128047 @default.
• W4323535601 cites W3093768976 @default.
• W4323535601 cites W3094860119 @default.
• W4323535601 cites W3102876585 @default.
• W4323535601 cites W3104537585 @default.
• W4323535601 cites W3109980976 @default.
• W4323535601 cites W3112376646 @default.
• W4323535601 cites W3119412259 @default.

• next