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- W4323538027 abstract "Abstract Bacteria belonging to the genus Vibrio include many known and emerging pathogens. Horizontal gene transfer of pathogenicity islands is a major contributor to the emergence of new pathogenic Vibrio strains. In the current report, we use the brine shrimp Artemia salina as a model to show that the marine bacterium Vibrio proteolyticus uses a mobile type VI secretion system, T6SS3, to intoxicate eukaryotic hosts. Two T6SS3 effectors, which were previously shown to induce inflammasome-mediated pyroptotic cell death in mammalian phagocytic cells, contribute to this toxicity. Furthermore, we find a novel, widespread T6SS3 effector that also contributes to the lethality mediated by this system against Artemia salina . Therefore, our results reveal a T6SS that is shared among diverse vibrios and mediates host lethality, indicating that it can lead to the emergence of new pathogenic strains." @default.
- W4323538027 created "2023-03-09" @default.
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- W4323538027 date "2023-03-06" @default.
- W4323538027 modified "2023-10-16" @default.
- W4323538027 title "A<i>Vibrio</i>T6SS-mediated lethality in a marine animal model" @default.
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- W4323538027 doi "https://doi.org/10.1101/2023.03.06.530577" @default.
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