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• W4323538539 abstract "Controlling infection-driven inflammation is a major clinical dilemma because of limited therapeutic options and possible adverse effects on microbial clearance. Compounding this difficulty is the continued emergence of drug-resistant bacteria, where experimental strategies aiming to augment inflammatory responses for enhanced microbial killing are not applicable treatment options for infections of vulnerable organs. As with corneal infections, severe or prolonged inflammation jeopardizes corneal transparency, leading to devastating vision loss. We hypothesized that keratin 6a-derived antimicrobial peptides (KAMPs) may be a two-pronged remedy capable of tackling bacterial infection and inflammation at once. We used murine peritoneal neutrophils and macrophages, together with an in vivo model of sterile corneal inflammation, to find that nontoxic and prohealing KAMPs with natural 10- and 18-amino acid sequences suppressed lipoteichoic acid (LTA)- and lipopolysaccharide (LPS)-induced NFκB and IRF3 activation, proinflammatory cytokine production, and phagocyte recruitment independently of their bactericidal function. Mechanistically, KAMPs not only competed with bacterial ligands for cell surface Toll-like receptor (TLR) and co-receptors (MD2, CD14, and TLR2) but also reduced cell surface availability of TLR2 and TLR4 through promotion of receptor endocytosis. Topical KAMP treatment effectively alleviated experimental bacterial keratitis, as evidenced by substantial reductions of corneal opacification, inflammatory cell infiltration, and bacterial burden. These findings reveal the TLR-targeting activities of KAMPs and demonstrate their therapeutic potential as a multifunctional drug for managing infectious inflammatory disease." @default.
• W4323538539 created "2023-03-09" @default.
• W4323538539 creator A5004261922 @default.
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• W4323538539 creator A5053384656 @default.
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• W4323538539 date "2023-03-08" @default.
• W4323538539 modified "2023-10-11" @default.
• W4323538539 title "Simultaneous control of infection and inflammation with keratin-derived antibacterial peptides targeting TLRs and co-receptors" @default.
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• W4323538539 cites W1839102767 @default.
• W4323538539 cites W1896283776 @default.
• W4323538539 cites W1967797356 @default.
• W4323538539 cites W1991203164 @default.
• W4323538539 cites W1991379729 @default.
• W4323538539 cites W1994062792 @default.
• W4323538539 cites W1995409001 @default.
• W4323538539 cites W1996671942 @default.
• W4323538539 cites W2026482455 @default.
• W4323538539 cites W2030589581 @default.
• W4323538539 cites W2032188844 @default.
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• W4323538539 cites W2044573804 @default.
• W4323538539 cites W2046546885 @default.
• W4323538539 cites W2051925512 @default.
• W4323538539 cites W2052406053 @default.
• W4323538539 cites W2057741044 @default.
• W4323538539 cites W2065053912 @default.
• W4323538539 cites W2065361083 @default.
• W4323538539 cites W2075185464 @default.
• W4323538539 cites W2083318468 @default.
• W4323538539 cites W2086676026 @default.
• W4323538539 cites W2102891573 @default.
• W4323538539 cites W2105731567 @default.
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• W4323538539 cites W2115850341 @default.
• W4323538539 cites W2125924155 @default.
• W4323538539 cites W2127934565 @default.
• W4323538539 cites W2130680119 @default.
• W4323538539 cites W2138230377 @default.
• W4323538539 cites W2143206150 @default.
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• W4323538539 cites W2151970324 @default.
• W4323538539 cites W2156994683 @default.
• W4323538539 cites W2162755344 @default.
• W4323538539 cites W2164487093 @default.
• W4323538539 cites W2179818990 @default.
• W4323538539 cites W2183361684 @default.
• W4323538539 cites W2257036949 @default.
• W4323538539 cites W2296404069 @default.
• W4323538539 cites W2345912746 @default.
• W4323538539 cites W2406001617 @default.
• W4323538539 cites W2463990453 @default.
• W4323538539 cites W2506275367 @default.
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• W4323538539 cites W2807760441 @default.
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• W4323538539 doi "https://doi.org/10.1126/scitranslmed.ade2909" @default.
• W4323538539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36888696" @default.
• W4323538539 hasPublicationYear "2023" @default.
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