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• W4323539122 abstract "Abstract The promising next-generation probiotic Faecalibacterium prausnitzii is one of the most abundant acetate-consuming, butyrate-producing bacteria in the healthy human gut. Yet, little is known about how acetate availability affects this bacterium’s gene expression strategies. Here, we show that, in the early stationary phase, F. duncaniae strain A2-165 (previously known as F. prausnitzii ) can strongly regulate the expression of metabolic and stress-response genes based on acetate availability. Using RNA-seq, we compared gene expression patterns between two growth phases (late exponential vs. early stationary) and two acetate levels (low: 3 mM vs. high: 23 mM). Remarkably, transcription levels were high for the gene encoding the MAM protein, a pattern that was unaffected by acetate levels. At low-acetate levels, a general stress response was activated, and protein synthesis expression was down-regulated. At high- acetate levels, there was greater expression of genes related to butyrate synthesis and to the importation of B vitamins and iron. Specifically, expression was strongly activated in the case of the feoAABC operon, which encodes a FeoB ferrous iron transporter, but not in the case of the feoAB gene, which encodes a second FeoB transporter. RT-PCR revealed that excess ferrous iron repressed feoB gene expression. Finally, we detected FeoB peptides from strain A2-165 in a healthy human fecal metaproteome. In conclusion, we characterized two early stationary lifestyles for F. duncaniae A2-165 that relate to acetate consumption. Through multiomics and targeted approaches, this work highlights the crucial role that the feoAABC operon might play in iron homeostasis in acetate-rich environments." @default.
• W4323539122 created "2023-03-09" @default.
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• W4323539122 date "2023-03-08" @default.
• W4323539122 modified "2023-09-25" @default.
• W4323539122 title "Faecalibacterium duncaniae A2-165 regulates the expression of butyrate synthesis, ferrous iron uptake, and stress-response genes based on acetate consumption" @default.
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• W4323539122 doi "https://doi.org/10.21203/rs.3.rs-2481125/v2" @default.
• W4323539122 hasPublicationYear "2023" @default.
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