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- W4323543763 abstract "Oxygen is toxic across all three domains of life. Yet, the underlying molecular mechanisms remain largely unknown. Here, we systematically investigate the major cellular pathways affected by excess molecular oxygen. We find that hyperoxia destabilizes a specific subset of Fe-S cluster (ISC)-containing proteins, resulting in impaired diphthamide synthesis, purine metabolism, nucleotide excision repair, and electron transport chain (ETC) function. Our findings translate to primary human lung cells and a mouse model of pulmonary oxygen toxicity. We demonstrate that the ETC is the most vulnerable to damage, resulting in decreased mitochondrial oxygen consumption. This leads to further tissue hyperoxia and cyclic damage of the additional ISC-containing pathways. In support of this model, primary ETC dysfunction in the Ndufs4 KO mouse model causes lung tissue hyperoxia and dramatically increases sensitivity to hyperoxia-mediated ISC damage. This work has important implications for hyperoxia pathologies, including bronchopulmonary dysplasia, ischemia-reperfusion injury, aging, and mitochondrial disorders." @default.
- W4323543763 created "2023-03-09" @default.
- W4323543763 creator A5022136914 @default.
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- W4323543763 creator A5079941605 @default.
- W4323543763 date "2023-03-01" @default.
- W4323543763 modified "2023-10-18" @default.
- W4323543763 title "Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes" @default.
- W4323543763 cites W1480113445 @default.
- W4323543763 cites W1550989404 @default.
- W4323543763 cites W165864682 @default.
- W4323543763 cites W1944019751 @default.
- W4323543763 cites W1966798922 @default.
- W4323543763 cites W1980270634 @default.
- W4323543763 cites W1984353960 @default.
- W4323543763 cites W1989953524 @default.
- W4323543763 cites W1991874179 @default.
- W4323543763 cites W1998726711 @default.
- W4323543763 cites W1998904773 @default.
- W4323543763 cites W2000703640 @default.
- W4323543763 cites W2002577710 @default.
- W4323543763 cites W2002674097 @default.
- W4323543763 cites W2005393891 @default.
- W4323543763 cites W2005868568 @default.
- W4323543763 cites W2010457001 @default.
- W4323543763 cites W2012053477 @default.
- W4323543763 cites W2013204504 @default.
- W4323543763 cites W2016556936 @default.
- W4323543763 cites W2017275974 @default.
- W4323543763 cites W2017793529 @default.
- W4323543763 cites W2022846088 @default.
- W4323543763 cites W2031211461 @default.
- W4323543763 cites W2033298896 @default.
- W4323543763 cites W2034411287 @default.
- W4323543763 cites W2038811853 @default.
- W4323543763 cites W2040031153 @default.
- W4323543763 cites W2040289024 @default.
- W4323543763 cites W2044217893 @default.
- W4323543763 cites W2046082575 @default.
- W4323543763 cites W2056716184 @default.
- W4323543763 cites W2061463796 @default.
- W4323543763 cites W2062424661 @default.
- W4323543763 cites W2070017721 @default.
- W4323543763 cites W2074214422 @default.
- W4323543763 cites W2074687883 @default.
- W4323543763 cites W2076558529 @default.
- W4323543763 cites W2076664790 @default.
- W4323543763 cites W2080658804 @default.
- W4323543763 cites W2085609942 @default.
- W4323543763 cites W2090627731 @default.
- W4323543763 cites W2093569530 @default.
- W4323543763 cites W2093688551 @default.
- W4323543763 cites W2093962790 @default.
- W4323543763 cites W2094552228 @default.
- W4323543763 cites W2110625603 @default.
- W4323543763 cites W2112743461 @default.
- W4323543763 cites W2112874497 @default.
- W4323543763 cites W2115144902 @default.
- W4323543763 cites W2116385293 @default.
- W4323543763 cites W2121349627 @default.
- W4323543763 cites W2122091775 @default.
- W4323543763 cites W2124801177 @default.
- W4323543763 cites W2144711788 @default.
- W4323543763 cites W2146682756 @default.
- W4323543763 cites W2152505144 @default.
- W4323543763 cites W2156572099 @default.
- W4323543763 cites W2157754987 @default.
- W4323543763 cites W2158045853 @default.
- W4323543763 cites W2158880205 @default.
- W4323543763 cites W2170418712 @default.
- W4323543763 cites W2171336403 @default.
- W4323543763 cites W2173350455 @default.
- W4323543763 cites W2174673748 @default.
- W4323543763 cites W2201689894 @default.
- W4323543763 cites W2252568502 @default.
- W4323543763 cites W2278345709 @default.
- W4323543763 cites W2278700498 @default.
- W4323543763 cites W2304223963 @default.
- W4323543763 cites W2395755052 @default.
- W4323543763 cites W2425948903 @default.
- W4323543763 cites W2479147916 @default.
- W4323543763 cites W2507486477 @default.
- W4323543763 cites W2520894026 @default.
- W4323543763 cites W2528556615 @default.
- W4323543763 cites W2532550607 @default.
- W4323543763 cites W2560601713 @default.
- W4323543763 cites W2581262905 @default.
- W4323543763 cites W2593221228 @default.
- W4323543763 cites W2594294830 @default.
- W4323543763 cites W2612960139 @default.
- W4323543763 cites W2788801492 @default.