Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323566734> ?p ?o ?g. }
- W4323566734 abstract "Introduction: Hypoxic-ischemic encephalopathy (HIE) is a crucial cause of neonatal death and neurological sequelae, but currently there is no effective therapy drug for HIE. Both oxidative stress and apoptosis play critical roles in the pathological development of HIE. Myricetin, a naturally extracted flavonol compound, exerts remarkable effects against oxidative stress, apoptosis, and inflammation. However, the role and underlying molecular mechanism of myricetin on HIE remain unclear. Methods: In this study, we established the neonatal rats hypoxic-ischemic (HI) brain damage model in vivo and CoCl 2 induced PC1 2 cell model in vitro to explore the neuroprotective effects of myricetin on HI injury, and illuminate the potential mechanism. Results: Our results showed that myricetin intervention could significantly reduce brain infarction volume, glia activation, apoptosis, and oxidative stress marker levels through activating NRF2 (Nuclear factor-E2-related factor 2) and increase the expressions of NRF2 downstream proteins NQO-1 and HO-1. In addition, the NRF2 inhibitor ML385 could significantly reverse the effects of myricetin. Conclusion: This study found that myricetin might alleviate oxidative stress and apoptosis through NRF2 signaling pathway to exert the protective role for HI injury, which suggested that myricetin might be a promising therapeutic agent for HIE." @default.
- W4323566734 created "2023-03-09" @default.
- W4323566734 creator A5013950655 @default.
- W4323566734 creator A5017223380 @default.
- W4323566734 creator A5017384752 @default.
- W4323566734 creator A5020721380 @default.
- W4323566734 creator A5024562487 @default.
- W4323566734 creator A5030266635 @default.
- W4323566734 creator A5036305472 @default.
- W4323566734 creator A5056752698 @default.
- W4323566734 creator A5078958991 @default.
- W4323566734 creator A5080413679 @default.
- W4323566734 date "2023-03-08" @default.
- W4323566734 modified "2023-09-26" @default.
- W4323566734 title "Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway" @default.
- W4323566734 cites W1976256528 @default.
- W4323566734 cites W1989842396 @default.
- W4323566734 cites W20087376 @default.
- W4323566734 cites W2027936807 @default.
- W4323566734 cites W2046808845 @default.
- W4323566734 cites W2051083565 @default.
- W4323566734 cites W2053698923 @default.
- W4323566734 cites W2079633022 @default.
- W4323566734 cites W2087377825 @default.
- W4323566734 cites W2117800935 @default.
- W4323566734 cites W2135138213 @default.
- W4323566734 cites W2138127628 @default.
- W4323566734 cites W2276769404 @default.
- W4323566734 cites W2345838873 @default.
- W4323566734 cites W2486467989 @default.
- W4323566734 cites W2511766821 @default.
- W4323566734 cites W2532167704 @default.
- W4323566734 cites W2536024417 @default.
- W4323566734 cites W2555794385 @default.
- W4323566734 cites W2561247095 @default.
- W4323566734 cites W2566119188 @default.
- W4323566734 cites W2582830902 @default.
- W4323566734 cites W2587033728 @default.
- W4323566734 cites W2612719840 @default.
- W4323566734 cites W2614711052 @default.
- W4323566734 cites W2749470720 @default.
- W4323566734 cites W2753995352 @default.
- W4323566734 cites W2769506786 @default.
- W4323566734 cites W2771525199 @default.
- W4323566734 cites W2775124792 @default.
- W4323566734 cites W2788659688 @default.
- W4323566734 cites W2793835425 @default.
- W4323566734 cites W2794508444 @default.
- W4323566734 cites W2799347886 @default.
- W4323566734 cites W2883738215 @default.
- W4323566734 cites W2910309796 @default.
- W4323566734 cites W2937649321 @default.
- W4323566734 cites W2938158459 @default.
- W4323566734 cites W2952281063 @default.
- W4323566734 cites W2955115231 @default.
- W4323566734 cites W2962356833 @default.
- W4323566734 cites W2971368165 @default.
- W4323566734 cites W2988771777 @default.
- W4323566734 cites W2992065654 @default.
- W4323566734 cites W2993290357 @default.
- W4323566734 cites W2995050802 @default.
- W4323566734 cites W2996547982 @default.
- W4323566734 cites W2998271943 @default.
- W4323566734 cites W3007794872 @default.
- W4323566734 cites W3008280701 @default.
- W4323566734 cites W3016576697 @default.
- W4323566734 cites W3016689111 @default.
- W4323566734 cites W3022219587 @default.
- W4323566734 cites W3024179740 @default.
- W4323566734 cites W3025469447 @default.
- W4323566734 cites W3029139219 @default.
- W4323566734 cites W3046632500 @default.
- W4323566734 cites W3102920036 @default.
- W4323566734 cites W3106887006 @default.
- W4323566734 cites W3111870857 @default.
- W4323566734 cites W3122267359 @default.
- W4323566734 cites W3124929681 @default.
- W4323566734 cites W3149168726 @default.
- W4323566734 cites W3160590484 @default.
- W4323566734 cites W3169025396 @default.
- W4323566734 cites W3197102565 @default.
- W4323566734 cites W4200186265 @default.
- W4323566734 cites W4214496379 @default.
- W4323566734 cites W4225115466 @default.
- W4323566734 cites W4226247235 @default.
- W4323566734 cites W4248078302 @default.
- W4323566734 cites W4285795418 @default.
- W4323566734 cites W4296175720 @default.
- W4323566734 doi "https://doi.org/10.3389/fphar.2023.1134464" @default.
- W4323566734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36969871" @default.
- W4323566734 hasPublicationYear "2023" @default.
- W4323566734 type Work @default.
- W4323566734 citedByCount "0" @default.
- W4323566734 crossrefType "journal-article" @default.
- W4323566734 hasAuthorship W4323566734A5013950655 @default.
- W4323566734 hasAuthorship W4323566734A5017223380 @default.
- W4323566734 hasAuthorship W4323566734A5017384752 @default.
- W4323566734 hasAuthorship W4323566734A5020721380 @default.
- W4323566734 hasAuthorship W4323566734A5024562487 @default.
- W4323566734 hasAuthorship W4323566734A5030266635 @default.