FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323567215> ?p ?o ?g. }

• W4323567215 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by a range of symptoms in which host immune response have been associated with disease progression. However, the putative role of regulatory T cells (Tregs) in determining COVID-19 outcomes has not been thoroughly investigated. Here, we compared peripheral Tregs between volunteers not previously infected with SARS-CoV-2 (healthy control [HC]) and volunteers who recovered from mild (Mild Recovered) and severe (Severe Recovered) COVID-19. Peripheral blood mononuclear cells (PBMC) were stimulated with SARS-CoV-2 synthetic peptides (Pool Spike CoV-2 and Pool CoV-2) or staphylococcal enterotoxin B (SEB). Results of a multicolor flow cytometric assay showed higher Treg frequency and expression of IL-10, IL-17, perforin, granzyme B, PD-1, and CD39/CD73 co-expression in Treg among the PBMC from the Mild Recovered group than in the Severe Recovered or HC groups for certain SARS-CoV-2 related stimulus. Moreover, Mild Recovered unstimulated samples presented a higher Tregs frequency and expression of IL-10 and granzyme B than did that of HC. Compared with Pool CoV-2 stimuli, Pool Spike CoV-2 reduced IL-10 expression and improved PD-1 expression in Tregs from volunteers in the Mild Recovered group. Interestingly, Pool Spike CoV-2 elicited a decrease in Treg IL-17 + frequency in the Severe Recovered group. In HC, the expression of latency-associated peptide (LAP) and cytotoxic granule co-expression by Tregs was higher in Pool CoV-2 stimulated samples. While Pool Spike CoV-2 stimulation reduced the frequency of IL-10 + and CTLA-4 + Tregs in PBMC from volunteers in the Mild Recovered group who had not experienced certain symptoms, higher levels of perforin and perforin + granzyme B + co-expression by Tregs were found in the Mild Recovered group in volunteers who had experienced dyspnea. Finally, we found differential expression of CD39 and CD73 among volunteers in the Mild Recovered group between those who had and had not experienced musculoskeletal pain. Collectively, our study suggests that changes in the immunosuppressive repertoire of Tregs can influence the development of a distinct COVID-19 clinical profile, revealing that a possible modulation of Tregs exists among volunteers of the Mild Recovered group between those who did and did not develop certain symptoms, leading to mild disease." @default.
• W4323567215 created "2023-03-09" @default.
• W4323567215 creator A5021648385 @default.
• W4323567215 creator A5031459946 @default.
• W4323567215 creator A5042166353 @default.
• W4323567215 creator A5044445876 @default.
• W4323567215 creator A5044783091 @default.
• W4323567215 creator A5050009753 @default.
• W4323567215 creator A5053502883 @default.
• W4323567215 creator A5061726998 @default.
• W4323567215 creator A5071740054 @default.
• W4323567215 date "2023-03-08" @default.
• W4323567215 modified "2023-09-30" @default.
• W4323567215 title "Differential regulatory T cell signature after recovery from mild COVID-19" @default.
• W4323567215 cites W1507917955 @default.
• W4323567215 cites W1528084970 @default.
• W4323567215 cites W1663740629 @default.
• W4323567215 cites W1872621433 @default.
• W4323567215 cites W1983626382 @default.
• W4323567215 cites W1987735044 @default.
• W4323567215 cites W2029640857 @default.
• W4323567215 cites W2046536341 @default.
• W4323567215 cites W2086556660 @default.
• W4323567215 cites W2115933910 @default.
• W4323567215 cites W2126072190 @default.
• W4323567215 cites W2130431539 @default.
• W4323567215 cites W2141652540 @default.
• W4323567215 cites W2142877732 @default.
• W4323567215 cites W2143889757 @default.
• W4323567215 cites W2159713565 @default.
• W4323567215 cites W2166662002 @default.
• W4323567215 cites W2167297937 @default.
• W4323567215 cites W2470430235 @default.
• W4323567215 cites W2591655768 @default.
• W4323567215 cites W2623733076 @default.
• W4323567215 cites W2755747302 @default.
• W4323567215 cites W2766901706 @default.
• W4323567215 cites W2767343890 @default.
• W4323567215 cites W2888976471 @default.
• W4323567215 cites W2941582519 @default.
• W4323567215 cites W3008028633 @default.
• W4323567215 cites W3025320502 @default.
• W4323567215 cites W3029291339 @default.
• W4323567215 cites W3032472005 @default.
• W4323567215 cites W3032543466 @default.
• W4323567215 cites W3037718428 @default.
• W4323567215 cites W3049243611 @default.
• W4323567215 cites W3085830444 @default.
• W4323567215 cites W3089936348 @default.
• W4323567215 cites W3090209951 @default.
• W4323567215 cites W3092136311 @default.
• W4323567215 cites W3093863147 @default.
• W4323567215 cites W3098710536 @default.
• W4323567215 cites W3119858919 @default.
• W4323567215 cites W3121002589 @default.
• W4323567215 cites W3124906490 @default.
• W4323567215 cites W3130206057 @default.
• W4323567215 cites W3132067897 @default.
• W4323567215 cites W3133874039 @default.
• W4323567215 cites W3134489892 @default.
• W4323567215 cites W3136782587 @default.
• W4323567215 cites W3139527275 @default.
• W4323567215 cites W3141611421 @default.
• W4323567215 cites W3152143964 @default.
• W4323567215 cites W3155183745 @default.
• W4323567215 cites W3159459865 @default.
• W4323567215 cites W3166555921 @default.
• W4323567215 cites W3173715707 @default.
• W4323567215 cites W3177683088 @default.
• W4323567215 cites W3182840995 @default.
• W4323567215 cites W3184951983 @default.
• W4323567215 cites W3185231871 @default.
• W4323567215 cites W3191780259 @default.
• W4323567215 cites W3200259362 @default.
• W4323567215 cites W3201702469 @default.
• W4323567215 cites W3203321093 @default.
• W4323567215 cites W3212922389 @default.
• W4323567215 cites W4200511947 @default.
• W4323567215 cites W4205553086 @default.
• W4323567215 cites W4207080708 @default.
• W4323567215 cites W4210792795 @default.
• W4323567215 cites W4213415374 @default.
• W4323567215 cites W4221026046 @default.
• W4323567215 cites W4224277375 @default.
• W4323567215 cites W4280505955 @default.
• W4323567215 doi "https://doi.org/10.3389/fimmu.2023.1078922" @default.
• W4323567215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36969257" @default.
• W4323567215 hasPublicationYear "2023" @default.
• W4323567215 type Work @default.
• W4323567215 citedByCount "0" @default.
• W4323567215 crossrefType "journal-article" @default.
• W4323567215 hasAuthorship W4323567215A5021648385 @default.
• W4323567215 hasAuthorship W4323567215A5031459946 @default.
• W4323567215 hasAuthorship W4323567215A5042166353 @default.
• W4323567215 hasAuthorship W4323567215A5044445876 @default.
• W4323567215 hasAuthorship W4323567215A5044783091 @default.
• W4323567215 hasAuthorship W4323567215A5050009753 @default.
• W4323567215 hasAuthorship W4323567215A5053502883 @default.
• W4323567215 hasAuthorship W4323567215A5061726998 @default.
• W4323567215 hasAuthorship W4323567215A5071740054 @default.

• next