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- W4323570003 abstract "In Epidermal Grow Factor Receptor (EGFR) mutant non-small-cell lung cancer (NSCLC), local radiotherapy (RT) has become a new standard of care, improving OS in oligoprogressive disease during tyrosine kinase inhibitors (TKIs) treatment. Concomitant consolidative thoracic RT might cause an impairment of normal lung function, due to possible toxicity arising from their combination. This leads, in clinical practice, to stop TKIs when RT is ongoing. As few data are available in this therapeutic setting, we evaluated the feasibility and tolerance of Intensity Modulated RT (IMRT) or Stereotactic Body Radiotherapy (SBRT) delivered by Cyberknife (CK) in pts with EGFR mutant NSCLC under TKIs treatment. Between April 2017 and June 2022, 20 patients (pts) with EGFR mutant stage IV NSCLC treated with concomitant RT (IMRT or SBRT) and TKIs, were evaluated retrospectively. Our main endpoint was lung toxicity, while OS was secondarily described. Post-treatment CT or PET scans were used to evaluate local response at 3 and 6 months. Clinical and radiological toxicities were assessed according to CTCAE v5.0. Survival curves were calculated by using the Kaplan-Meier method. Median follow up (FU) was 13.1 months (0.5-51.9). Median time occurring between start of TKIs and start of RT was 10.5 months (1.1-71). Treatments were delivered with HT (14/20) and CK (6/20). The mean PTV was 147.98cc (20.23-620cc). TKIs administrated were Osimertinib (11/20), Erlotinib (4/20), Gefitinib (3/20) and Afatinib (2/20). Median OS was not reached. Median PFS after concomitant TKIs/RT was 6.8 months (0.5-56 months). Acute toxicity after RT was observed in 25% of pts (G2). At 3 months FU, toxicity was observed in 68% of pts: 77% G1, 23% G2; four pts showed local CR, 10 PR, 3 SD, 2 PD. At 6 months FU 44% of pts showed G1 toxicities; 6 pts showed local CR, 5 PR, 1 SD and 6 PD. The concomitant administration of thoracic RT and TKIs is safe and well tolerated. No increased toxicity has been recorded compared to literature, thus suggesting the feasibility of the association of these different treatment modality. Analyses of a larger sample size and a longer clinical follow-up are needed to confirm these preliminary results." @default.
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- W4323570003 date "2023-03-01" @default.
- W4323570003 modified "2023-09-25" @default.
- W4323570003 title "105P Thoracic radiotherapy and tyrosine kinase inhibitors association: Results from a monoinstitutional experience" @default.
- W4323570003 doi "https://doi.org/10.1016/j.esmoop.2023.100963" @default.
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