Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323648319> ?p ?o ?g. }
- W4323648319 abstract "Abstract Styxl2, a poorly characterized pseudophosphatase, was identified as a transcriptional target of the Jak1-Stat1 pathway during myoblast differentiation in culture. Styxl2 is specifically expressed in vertebrate striated muscles. By gene knockdown or genetic knockout, we found that Styxl2 plays an essential role in maintaining sarcomere integrity in developing muscles of both zebrafish and mice. To further reveal the functions of Styxl2 in adult muscles, we generated two inducible knockout mouse models: one with Styxl2 being deleted in mature myofibers to assess its role in sarcomere maintenance, and the other in adult muscle satellite cells (MuSCs) to assess its role in de novo sarcomere assembly. We find that Styxl2 is not required for sarcomere maintenance but functions in de novo sarcomere assembly during injury-induced muscle regeneration. Mechanistically, Styxl2 interacts with non-muscle myosin IIs, enhances their ubiquitination, and targets them for autophagy-dependent degradation. Without Styxl2, the degradation of non-muscle myosin IIs is delayed, which leads to defective sarcomere assembly and force generation. Thus, Styxl2 promotes de novo sarcomere assembly by interacting with non-muscle myosin IIs and facilitating their autophagic degradation." @default.
- W4323648319 created "2023-03-10" @default.
- W4323648319 creator A5000328709 @default.
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- W4323648319 creator A5056069573 @default.
- W4323648319 creator A5065246148 @default.
- W4323648319 creator A5078663555 @default.
- W4323648319 creator A5090013626 @default.
- W4323648319 date "2022-10-22" @default.
- W4323648319 modified "2023-10-05" @default.
- W4323648319 title "Styxl2 regulates<i>de novo</i>sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation" @default.
- W4323648319 cites W1559125846 @default.
- W4323648319 cites W1581656442 @default.
- W4323648319 cites W1898920617 @default.
- W4323648319 cites W1943069338 @default.
- W4323648319 cites W1967720431 @default.
- W4323648319 cites W1969918683 @default.
- W4323648319 cites W1970663322 @default.
- W4323648319 cites W1970944947 @default.
- W4323648319 cites W1971378456 @default.
- W4323648319 cites W1983687712 @default.
- W4323648319 cites W1984193862 @default.
- W4323648319 cites W1985539380 @default.
- W4323648319 cites W2008306394 @default.
- W4323648319 cites W2009536147 @default.
- W4323648319 cites W2011371821 @default.
- W4323648319 cites W2012917093 @default.
- W4323648319 cites W2014918593 @default.
- W4323648319 cites W2016923195 @default.
- W4323648319 cites W2018636808 @default.
- W4323648319 cites W2025422229 @default.
- W4323648319 cites W2025665129 @default.
- W4323648319 cites W2025957803 @default.
- W4323648319 cites W2031636974 @default.
- W4323648319 cites W2035901470 @default.
- W4323648319 cites W2036787961 @default.
- W4323648319 cites W2036903182 @default.
- W4323648319 cites W2038132994 @default.
- W4323648319 cites W2042249618 @default.
- W4323648319 cites W2043617798 @default.
- W4323648319 cites W2044677343 @default.
- W4323648319 cites W2048494900 @default.
- W4323648319 cites W2058172887 @default.
- W4323648319 cites W2058846791 @default.
- W4323648319 cites W2060740193 @default.
- W4323648319 cites W206915548 @default.
- W4323648319 cites W2069680849 @default.
- W4323648319 cites W2070078057 @default.
- W4323648319 cites W2077272494 @default.
- W4323648319 cites W2077872232 @default.
- W4323648319 cites W2078718449 @default.
- W4323648319 cites W2080592158 @default.
- W4323648319 cites W2087481108 @default.
- W4323648319 cites W2103140083 @default.
- W4323648319 cites W2105707485 @default.
- W4323648319 cites W2106297262 @default.
- W4323648319 cites W2107137602 @default.
- W4323648319 cites W2107277218 @default.
- W4323648319 cites W2107283445 @default.
- W4323648319 cites W2107575131 @default.
- W4323648319 cites W2111043607 @default.
- W4323648319 cites W2111357564 @default.
- W4323648319 cites W2119423333 @default.
- W4323648319 cites W2125331380 @default.
- W4323648319 cites W2128057048 @default.
- W4323648319 cites W2132416790 @default.
- W4323648319 cites W2133085510 @default.
- W4323648319 cites W2134029077 @default.
- W4323648319 cites W2135402574 @default.
- W4323648319 cites W2142803231 @default.
- W4323648319 cites W2147192856 @default.
- W4323648319 cites W2150969156 @default.
- W4323648319 cites W2162101893 @default.
- W4323648319 cites W2256814646 @default.
- W4323648319 cites W2262858406 @default.
- W4323648319 cites W2346903294 @default.
- W4323648319 cites W2398436462 @default.
- W4323648319 cites W2605753431 @default.
- W4323648319 cites W2607132510 @default.
- W4323648319 cites W2783266799 @default.
- W4323648319 cites W2800047565 @default.
- W4323648319 cites W2803309574 @default.
- W4323648319 cites W2886259987 @default.
- W4323648319 cites W2904311946 @default.
- W4323648319 cites W2904562298 @default.
- W4323648319 cites W2947094943 @default.
- W4323648319 cites W2980453182 @default.
- W4323648319 cites W3023816411 @default.
- W4323648319 cites W3030415176 @default.
- W4323648319 cites W3030585765 @default.
- W4323648319 cites W3031848555 @default.
- W4323648319 cites W3041148217 @default.
- W4323648319 cites W3084911715 @default.
- W4323648319 cites W3146153743 @default.