FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323654375> ?p ?o ?g. }

• W4323654375 abstract "Abstract Antibodies capable of neutralising SARS-CoV-2 have been well studied, but the Fc receptor-dependent antibody activities that also significantly impact the course of infection have not been studied in such depth. SARS-CoV-2 infection induces antibody-dependent NK cell responses targeting multiple antigens, however, as most vaccines induce only anti-spike antibodies, we investigated spike-specific antibody-dependent cellular cytotoxicity (ADCC). Vaccination produced antibodies that only weakly induced ADCC, however, antibodies from individuals who were infected prior to vaccination (‘hybrid’ immunity) elicited much stronger anti-spike ADCC. Quantitative and qualitative aspects of humoral immunity contributed to this capability, with infection skewing IgG antibody production towards S2, vaccination skewing towards S1 and hybrid immunity evoking strong responses against both domains. The capacity for hybrid immunity to provide superior spike-directed ADCC was associated with selectively increased antibody responses against epitopes within both S1 and S2. Antibodies targeting both spike domains were important for strong antibody-dependent NK cell activation, with three regions of antibody reactivity outside the receptor-binding domain (RBD) corresponding with potent anti-spike ADCC. Consequently, ADCC induced by hybrid immunity with ancestral antigen was conserved against variants containing neutralisation escape mutations in the RBD [Delta and Omicron (BA.1)]. Induction of antibodies recognizing a broad range of spike epitopes and eliciting strong and durable ADCC may partially explain why hybrid immunity provides superior protection against infection and disease than vaccination alone, and demonstrates that spike-only subunit vaccines would benefit from strategies to induce a combination of S1- and S2-specific antibody responses. Significance Neutralising antibodies prevent the entry of cell-free virus, however, antibodies that promote Fc-dependent activities such as ADCC are critical to control cell-associated virus. Although current SARS-CoV-2 vaccines induce potent neutralising antibodies, they fail to induce robust ADCC. Our demonstration that hybrid immunity induces superior ADCC with pan-variant activity may partially explain why hybrid immunity offers enhanced protection against reinfection. It also highlights that vaccine strategies based on expression of the spike subunit alone should not focus solely on inducing antibody responses targeting the receptor binding domain." @default.
• W4323654375 created "2023-03-10" @default.
• W4323654375 creator A5004173497 @default.
• W4323654375 creator A5023252680 @default.
• W4323654375 creator A5026509784 @default.
• W4323654375 creator A5031027003 @default.
• W4323654375 creator A5039835159 @default.
• W4323654375 creator A5045279185 @default.
• W4323654375 creator A5061315953 @default.
• W4323654375 creator A5063522604 @default.
• W4323654375 creator A5083940227 @default.
• W4323654375 date "2023-03-09" @default.
• W4323654375 modified "2023-10-18" @default.
• W4323654375 title "Hybrid immunity elicits potent cross-variant ADCC against SARS-CoV-2 through a combination of anti-S1 and S2 antibodies" @default.
• W4323654375 cites W2091805637 @default.
• W4323654375 cites W2123263006 @default.
• W4323654375 cites W2143509157 @default.
• W4323654375 cites W2169656611 @default.
• W4323654375 cites W2921400779 @default.
• W4323654375 cites W3045578670 @default.
• W4323654375 cites W3089112814 @default.
• W4323654375 cites W3096867322 @default.
• W4323654375 cites W3099530525 @default.
• W4323654375 cites W3111128314 @default.
• W4323654375 cites W3111255098 @default.
• W4323654375 cites W3128595283 @default.
• W4323654375 cites W3132092747 @default.
• W4323654375 cites W3132982761 @default.
• W4323654375 cites W3155608666 @default.
• W4323654375 cites W3161511556 @default.
• W4323654375 cites W3163651782 @default.
• W4323654375 cites W3167555428 @default.
• W4323654375 cites W3172271359 @default.
• W4323654375 cites W3177362856 @default.
• W4323654375 cites W3194402687 @default.
• W4323654375 cites W3195868522 @default.
• W4323654375 cites W3196490942 @default.
• W4323654375 cites W3199849883 @default.
• W4323654375 cites W3199974613 @default.
• W4323654375 cites W3202903389 @default.
• W4323654375 cites W3204737766 @default.
• W4323654375 cites W3207841857 @default.
• W4323654375 cites W3211172645 @default.
• W4323654375 cites W3213454751 @default.
• W4323654375 cites W3214796554 @default.
• W4323654375 cites W3217227264 @default.
• W4323654375 cites W4205870633 @default.
• W4323654375 cites W4206481051 @default.
• W4323654375 cites W4206684097 @default.
• W4323654375 cites W4206914007 @default.
• W4323654375 cites W4210539036 @default.
• W4323654375 cites W4210664421 @default.
• W4323654375 cites W4210888864 @default.
• W4323654375 cites W4220770600 @default.
• W4323654375 cites W4221103003 @default.
• W4323654375 cites W4223544666 @default.
• W4323654375 cites W4224268482 @default.
• W4323654375 cites W4224284079 @default.
• W4323654375 cites W4224285134 @default.
• W4323654375 cites W4225112745 @default.
• W4323654375 cites W4226406206 @default.
• W4323654375 cites W4229081658 @default.
• W4323654375 cites W4246271978 @default.
• W4323654375 cites W4280574486 @default.
• W4323654375 cites W4281557772 @default.
• W4323654375 cites W4281843570 @default.
• W4323654375 cites W4282552514 @default.
• W4323654375 cites W4288067813 @default.
• W4323654375 cites W4293090313 @default.
• W4323654375 cites W4296034962 @default.
• W4323654375 cites W4296356812 @default.
• W4323654375 cites W4296701253 @default.
• W4323654375 cites W4304203302 @default.
• W4323654375 cites W4307050663 @default.
• W4323654375 cites W4307441048 @default.
• W4323654375 cites W4311744391 @default.
• W4323654375 doi "https://doi.org/10.1101/2023.03.09.531709" @default.
• W4323654375 hasPublicationYear "2023" @default.
• W4323654375 type Work @default.
• W4323654375 citedByCount "1" @default.
• W4323654375 countsByYear W43236543752023 @default.
• W4323654375 crossrefType "posted-content" @default.
• W4323654375 hasAuthorship W4323654375A5004173497 @default.
• W4323654375 hasAuthorship W4323654375A5023252680 @default.
• W4323654375 hasAuthorship W4323654375A5026509784 @default.
• W4323654375 hasAuthorship W4323654375A5031027003 @default.
• W4323654375 hasAuthorship W4323654375A5039835159 @default.
• W4323654375 hasAuthorship W4323654375A5045279185 @default.
• W4323654375 hasAuthorship W4323654375A5061315953 @default.
• W4323654375 hasAuthorship W4323654375A5063522604 @default.
• W4323654375 hasAuthorship W4323654375A5083940227 @default.
• W4323654375 hasBestOaLocation W43236543751 @default.
• W4323654375 hasConcept C147483822 @default.
• W4323654375 hasConcept C159047783 @default.
• W4323654375 hasConcept C159654299 @default.
• W4323654375 hasConcept C195616568 @default.
• W4323654375 hasConcept C203014093 @default.
• W4323654375 hasConcept C22070199 @default.
• W4323654375 hasConcept C2776548049 @default.
• W4323654375 hasConcept C2779341262 @default.

• next