Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323657474> ?p ?o ?g. }
- W4323657474 endingPage "400" @default.
- W4323657474 startingPage "386" @default.
- W4323657474 abstract "Topologically associating domains (TADs) have emerged as basic structural and functional units of genome organization and have been determined by many computational methods from Hi-C contact maps. However, the TADs obtained by different methods vary greatly, which makes the accurate determination of TADs a challenging issue and hinders subsequent biological analyses about their organization and functions. Obvious inconsistencies among the TADs identified by different methods indeed make the statistical and biological properties of TADs overly depend on the chosen method rather than on the data. To this end, we use the consensus structural information captured by these methods to define the TAD separation landscape for decoding the consensus domain organization of the 3D genome. We show that the TAD separation landscape could be used to compare domain boundaries across multiple cell types for discovering conserved and divergent topological structures, decipher three types of boundary regions with diverse biological features, and identify consensus TADs (ConsTADs). We illustrate that these analyses could deepen our understanding of the relationships between the topological domains and chromatin states, gene expression, and DNA replication timing." @default.
- W4323657474 created "2023-03-10" @default.
- W4323657474 creator A5037846307 @default.
- W4323657474 creator A5065205702 @default.
- W4323657474 creator A5076619069 @default.
- W4323657474 creator A5084753529 @default.
- W4323657474 date "2023-03-01" @default.
- W4323657474 modified "2023-10-16" @default.
- W4323657474 title "Defining the separation landscape of topological domains for decoding consensus domain organization of the 3D genome" @default.
- W4323657474 cites W1859117663 @default.
- W4323657474 cites W1968931043 @default.
- W4323657474 cites W1973062929 @default.
- W4323657474 cites W1979513200 @default.
- W4323657474 cites W1991149014 @default.
- W4323657474 cites W2009576540 @default.
- W4323657474 cites W2014677321 @default.
- W4323657474 cites W2018363492 @default.
- W4323657474 cites W2032140335 @default.
- W4323657474 cites W2064537118 @default.
- W4323657474 cites W2070021921 @default.
- W4323657474 cites W2071508810 @default.
- W4323657474 cites W2073026107 @default.
- W4323657474 cites W2090037139 @default.
- W4323657474 cites W2097798909 @default.
- W4323657474 cites W2114083195 @default.
- W4323657474 cites W2115728199 @default.
- W4323657474 cites W2122796505 @default.
- W4323657474 cites W2146339031 @default.
- W4323657474 cites W2159479483 @default.
- W4323657474 cites W2163412235 @default.
- W4323657474 cites W2195190137 @default.
- W4323657474 cites W2227178360 @default.
- W4323657474 cites W2234143669 @default.
- W4323657474 cites W2310342073 @default.
- W4323657474 cites W2324665822 @default.
- W4323657474 cites W2345889914 @default.
- W4323657474 cites W2416744721 @default.
- W4323657474 cites W2557097554 @default.
- W4323657474 cites W2567008309 @default.
- W4323657474 cites W2568062379 @default.
- W4323657474 cites W2581883027 @default.
- W4323657474 cites W2592955530 @default.
- W4323657474 cites W2625231465 @default.
- W4323657474 cites W2738924259 @default.
- W4323657474 cites W2745865732 @default.
- W4323657474 cites W2755736028 @default.
- W4323657474 cites W2769659182 @default.
- W4323657474 cites W2784063494 @default.
- W4323657474 cites W2800968671 @default.
- W4323657474 cites W2811431585 @default.
- W4323657474 cites W2885386724 @default.
- W4323657474 cites W2891348030 @default.
- W4323657474 cites W2891870314 @default.
- W4323657474 cites W2898514070 @default.
- W4323657474 cites W2904120442 @default.
- W4323657474 cites W2937151182 @default.
- W4323657474 cites W2951765178 @default.
- W4323657474 cites W2987347191 @default.
- W4323657474 cites W2994125457 @default.
- W4323657474 cites W2996196683 @default.
- W4323657474 cites W3013167866 @default.
- W4323657474 cites W3050508217 @default.
- W4323657474 cites W3103145119 @default.
- W4323657474 cites W3104413386 @default.
- W4323657474 cites W3124312836 @default.
- W4323657474 cites W3126332871 @default.
- W4323657474 cites W3160196351 @default.
- W4323657474 cites W3207552523 @default.
- W4323657474 doi "https://doi.org/10.1101/gr.277187.122" @default.
- W4323657474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36894325" @default.
- W4323657474 hasPublicationYear "2023" @default.
- W4323657474 type Work @default.
- W4323657474 citedByCount "1" @default.
- W4323657474 countsByYear W43236574742023 @default.
- W4323657474 crossrefType "journal-article" @default.
- W4323657474 hasAuthorship W4323657474A5037846307 @default.
- W4323657474 hasAuthorship W4323657474A5065205702 @default.
- W4323657474 hasAuthorship W4323657474A5076619069 @default.
- W4323657474 hasAuthorship W4323657474A5084753529 @default.
- W4323657474 hasBestOaLocation W43236574741 @default.
- W4323657474 hasConcept C104317684 @default.
- W4323657474 hasConcept C114614502 @default.
- W4323657474 hasConcept C134306372 @default.
- W4323657474 hasConcept C141231307 @default.
- W4323657474 hasConcept C164614171 @default.
- W4323657474 hasConcept C184720557 @default.
- W4323657474 hasConcept C33923547 @default.
- W4323657474 hasConcept C36503486 @default.
- W4323657474 hasConcept C41008148 @default.
- W4323657474 hasConcept C54355233 @default.
- W4323657474 hasConcept C70721500 @default.
- W4323657474 hasConcept C78458016 @default.
- W4323657474 hasConcept C83640560 @default.
- W4323657474 hasConcept C86803240 @default.
- W4323657474 hasConceptScore W4323657474C104317684 @default.
- W4323657474 hasConceptScore W4323657474C114614502 @default.
- W4323657474 hasConceptScore W4323657474C134306372 @default.
- W4323657474 hasConceptScore W4323657474C141231307 @default.