FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323660488> ?p ?o ?g. }

• W4323660488 endingPage "941.e8" @default.
• W4323660488 startingPage "927" @default.
• W4323660488 abstract "Mitophagy is a form of selective autophagy that disposes of superfluous and potentially damage-inducing organelles in a tightly controlled manner. While the machinery involved in mitophagy induction is well known, the regulation of the components is less clear. Here, we demonstrate that TNIP1 knockout in HeLa cells accelerates mitophagy rates and that ectopic TNIP1 negatively regulates the rate of mitophagy. These functions of TNIP1 depend on an evolutionarily conserved LIR motif as well as an AHD3 domain, which are required for binding to the LC3/GABARAP family of proteins and the autophagy receptor TAX1BP1, respectively. We further show that phosphorylation appears to regulate its association with the ULK1 complex member FIP200, allowing TNIP1 to compete with autophagy receptors, which provides a molecular rationale for its inhibitory function during mitophagy. Taken together, our findings describe TNIP1 as a negative regulator of mitophagy that acts at the early steps of autophagosome biogenesis." @default.
• W4323660488 created "2023-03-10" @default.
• W4323660488 creator A5000627749 @default.
• W4323660488 creator A5001067570 @default.
• W4323660488 creator A5016443408 @default.
• W4323660488 creator A5016723424 @default.
• W4323660488 creator A5024013808 @default.
• W4323660488 creator A5050464388 @default.
• W4323660488 creator A5070515921 @default.
• W4323660488 creator A5077902013 @default.
• W4323660488 creator A5088762881 @default.
• W4323660488 date "2023-03-01" @default.
• W4323660488 modified "2023-10-17" @default.
• W4323660488 title "TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1" @default.
• W4323660488 cites W1523693806 @default.
• W4323660488 cites W1860864010 @default.
• W4323660488 cites W1965544877 @default.
• W4323660488 cites W1977709885 @default.
• W4323660488 cites W1995111406 @default.
• W4323660488 cites W2014918593 @default.
• W4323660488 cites W2025872915 @default.
• W4323660488 cites W2029558360 @default.
• W4323660488 cites W2045805479 @default.
• W4323660488 cites W2058065156 @default.
• W4323660488 cites W2064396641 @default.
• W4323660488 cites W2068700852 @default.
• W4323660488 cites W2073453659 @default.
• W4323660488 cites W2103230459 @default.
• W4323660488 cites W2106969933 @default.
• W4323660488 cites W2108077848 @default.
• W4323660488 cites W2153819917 @default.
• W4323660488 cites W2156356581 @default.
• W4323660488 cites W2167279371 @default.
• W4323660488 cites W2167844024 @default.
• W4323660488 cites W2170329089 @default.
• W4323660488 cites W2173122519 @default.
• W4323660488 cites W2547933649 @default.
• W4323660488 cites W2555734739 @default.
• W4323660488 cites W2743254891 @default.
• W4323660488 cites W2754956126 @default.
• W4323660488 cites W2792549532 @default.
• W4323660488 cites W2895574251 @default.
• W4323660488 cites W2913143413 @default.
• W4323660488 cites W2918672868 @default.
• W4323660488 cites W2922182434 @default.
• W4323660488 cites W2955961927 @default.
• W4323660488 cites W2960510458 @default.
• W4323660488 cites W2981996286 @default.
• W4323660488 cites W2997831353 @default.
• W4323660488 cites W2998173680 @default.
• W4323660488 cites W3103001608 @default.
• W4323660488 cites W3105265817 @default.
• W4323660488 cites W3127193935 @default.
• W4323660488 cites W3135463624 @default.
• W4323660488 cites W3159538085 @default.
• W4323660488 cites W3197290161 @default.
• W4323660488 cites W4214739556 @default.
• W4323660488 cites W4226286160 @default.
• W4323660488 cites W4293701273 @default.
• W4323660488 cites W4304141608 @default.
• W4323660488 cites W4307366279 @default.
• W4323660488 cites W4310172340 @default.
• W4323660488 cites W4313251164 @default.
• W4323660488 doi "https://doi.org/10.1016/j.molcel.2023.02.023" @default.
• W4323660488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36898370" @default.
• W4323660488 hasPublicationYear "2023" @default.
• W4323660488 type Work @default.
• W4323660488 citedByCount "5" @default.
• W4323660488 countsByYear W43236604882023 @default.
• W4323660488 crossrefType "journal-article" @default.
• W4323660488 hasAuthorship W4323660488A5000627749 @default.
• W4323660488 hasAuthorship W4323660488A5001067570 @default.
• W4323660488 hasAuthorship W4323660488A5016443408 @default.
• W4323660488 hasAuthorship W4323660488A5016723424 @default.
• W4323660488 hasAuthorship W4323660488A5024013808 @default.
• W4323660488 hasAuthorship W4323660488A5050464388 @default.
• W4323660488 hasAuthorship W4323660488A5070515921 @default.
• W4323660488 hasAuthorship W4323660488A5077902013 @default.
• W4323660488 hasAuthorship W4323660488A5088762881 @default.
• W4323660488 hasConcept C104317684 @default.
• W4323660488 hasConcept C11960822 @default.
• W4323660488 hasConcept C131934819 @default.
• W4323660488 hasConcept C168296220 @default.
• W4323660488 hasConcept C190283241 @default.
• W4323660488 hasConcept C203522944 @default.
• W4323660488 hasConcept C2779324830 @default.
• W4323660488 hasConcept C2780124434 @default.
• W4323660488 hasConcept C55493867 @default.
• W4323660488 hasConcept C6929976 @default.
• W4323660488 hasConcept C71680706 @default.
• W4323660488 hasConcept C86803240 @default.
• W4323660488 hasConcept C95444343 @default.
• W4323660488 hasConcept C97029542 @default.
• W4323660488 hasConceptScore W4323660488C104317684 @default.
• W4323660488 hasConceptScore W4323660488C11960822 @default.
• W4323660488 hasConceptScore W4323660488C131934819 @default.
• W4323660488 hasConceptScore W4323660488C168296220 @default.
• W4323660488 hasConceptScore W4323660488C190283241 @default.

• next