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- W4323663483 endingPage "461" @default.
- W4323663483 startingPage "461" @default.
- W4323663483 abstract "Schizophrenia is characterized by symptoms of psychosis and sociocognitive deficits. Considering oxytocin’s antipsychotic and prosocial properties, numerous clinical, and preclinical studies have explored the neuropeptide’s therapeutic efficacy. Sex differences in the clinical course of schizophrenia, as well as in oxytocin-mediated behaviors, indicate the involvement of gonadal steroid hormones. The current narrative review aimed to explore empirical evidence on the interplay between schizophrenia psychopathology and oxytocin’s therapeutic potential in consideration of female gonadal steroid interactions, with a focus on estrogens. The review was conducted using the PubMed and PsychINFO databases and conforms to the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines. The results suggest a potential synergistic effect of the combined antipsychotic effect of oxytocin and neuroprotective effect of estrogen on schizophrenia. Consideration of typical menstrual cycle-related hormonal changes is warranted and further research is needed to confirm this assumption." @default.
- W4323663483 created "2023-03-10" @default.
- W4323663483 creator A5069675595 @default.
- W4323663483 creator A5076427622 @default.
- W4323663483 creator A5081025298 @default.
- W4323663483 date "2023-03-08" @default.
- W4323663483 modified "2023-09-25" @default.
- W4323663483 title "Exploring a Possible Interplay between Schizophrenia, Oxytocin, and Estrogens: A Narrative Review" @default.
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