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- W4323664746 endingPage "5236" @default.
- W4323664746 startingPage "5236" @default.
- W4323664746 abstract "Androsta-4-ene-3,17-dione (AD), androsta-1,4-diene-3,17-dione (ADD), and 9α-hydroxy-4-androstene-3,17-dione (9-OHAD), which belong to C-19 steroids, are critical steroid-based drug intermediates. The biotransformation of phytosterols into C-19 steroids by Mycolicibacterium cell factories is the core step in the synthesis of steroid-based drugs. The production performance of engineered mycolicibacterial strains has been effectively enhanced by sterol core metabolic modification. In recent years, research on the non-core metabolic pathway of steroids (NCMS) in mycolicibacterial strains has made significant progress. This review discusses the molecular mechanisms and metabolic modifications of NCMS for accelerating sterol uptake, regulating coenzyme I balance, promoting propionyl-CoA metabolism, reducing reactive oxygen species, and regulating energy metabolism. In addition, the recent applications of biotechnology in steroid intermediate production are summarized and compared, and the future development trend of NCMS research is discussed. This review provides powerful theoretical support for metabolic regulation in the biotransformation of phytosterols." @default.
- W4323664746 created "2023-03-10" @default.
- W4323664746 creator A5022802322 @default.
- W4323664746 creator A5056053569 @default.
- W4323664746 creator A5064651694 @default.
- W4323664746 creator A5085174017 @default.
- W4323664746 date "2023-03-09" @default.
- W4323664746 modified "2023-10-12" @default.
- W4323664746 title "New Insights into the Modification of the Non-Core Metabolic Pathway of Steroids in Mycolicibacterium and the Application of Fermentation Biotechnology in C-19 Steroid Production" @default.
- W4323664746 cites W1530595927 @default.
- W4323664746 cites W1555985610 @default.
- W4323664746 cites W1560272301 @default.
- W4323664746 cites W156344840 @default.
- W4323664746 cites W181645241 @default.
- W4323664746 cites W1938275102 @default.
- W4323664746 cites W1944426035 @default.
- W4323664746 cites W1967162271 @default.
- W4323664746 cites W1972441718 @default.
- W4323664746 cites W1978086853 @default.
- W4323664746 cites W1990693599 @default.
- W4323664746 cites W1990817009 @default.
- W4323664746 cites W1990951667 @default.
- W4323664746 cites W1991233072 @default.
- W4323664746 cites W1998028440 @default.
- W4323664746 cites W2000813574 @default.
- W4323664746 cites W2001454891 @default.
- W4323664746 cites W2002424274 @default.
- W4323664746 cites W2009514803 @default.
- W4323664746 cites W2009970226 @default.
- W4323664746 cites W2012730005 @default.
- W4323664746 cites W2029448301 @default.
- W4323664746 cites W2030303873 @default.
- W4323664746 cites W2043004111 @default.
- W4323664746 cites W2044740604 @default.
- W4323664746 cites W2051438141 @default.
- W4323664746 cites W2057226210 @default.
- W4323664746 cites W2057569736 @default.
- W4323664746 cites W2062797164 @default.
- W4323664746 cites W2063425168 @default.
- W4323664746 cites W2065291309 @default.
- W4323664746 cites W2067252347 @default.
- W4323664746 cites W2072186466 @default.
- W4323664746 cites W2076264079 @default.
- W4323664746 cites W2076635819 @default.
- W4323664746 cites W2079888561 @default.
- W4323664746 cites W2085325272 @default.
- W4323664746 cites W2098303916 @default.
- W4323664746 cites W2099925845 @default.
- W4323664746 cites W2101648876 @default.
- W4323664746 cites W2130857599 @default.
- W4323664746 cites W2131816099 @default.
- W4323664746 cites W2133215972 @default.
- W4323664746 cites W2133593669 @default.
- W4323664746 cites W2138020404 @default.
- W4323664746 cites W2140610868 @default.
- W4323664746 cites W2141417334 @default.
- W4323664746 cites W2155375392 @default.
- W4323664746 cites W2159104220 @default.
- W4323664746 cites W2164552724 @default.
- W4323664746 cites W2168670094 @default.
- W4323664746 cites W2171840103 @default.
- W4323664746 cites W2171944183 @default.
- W4323664746 cites W2212404300 @default.
- W4323664746 cites W2226081765 @default.
- W4323664746 cites W2252941071 @default.
- W4323664746 cites W2277779396 @default.
- W4323664746 cites W2283144829 @default.
- W4323664746 cites W2289193457 @default.
- W4323664746 cites W2299928419 @default.
- W4323664746 cites W2466489412 @default.
- W4323664746 cites W2473483657 @default.
- W4323664746 cites W2541108596 @default.
- W4323664746 cites W2555074280 @default.
- W4323664746 cites W2562950907 @default.
- W4323664746 cites W2564932068 @default.
- W4323664746 cites W2575974171 @default.
- W4323664746 cites W2577254678 @default.
- W4323664746 cites W2581734508 @default.
- W4323664746 cites W2594077946 @default.
- W4323664746 cites W2606132092 @default.
- W4323664746 cites W2618482208 @default.
- W4323664746 cites W2623120792 @default.
- W4323664746 cites W2668500951 @default.
- W4323664746 cites W2744432644 @default.
- W4323664746 cites W2758681502 @default.
- W4323664746 cites W2763289631 @default.
- W4323664746 cites W2764251525 @default.
- W4323664746 cites W2766457803 @default.
- W4323664746 cites W2773008448 @default.
- W4323664746 cites W2783504718 @default.
- W4323664746 cites W2791140662 @default.
- W4323664746 cites W2791765621 @default.
- W4323664746 cites W2793075685 @default.
- W4323664746 cites W2793787014 @default.
- W4323664746 cites W2803809638 @default.
- W4323664746 cites W2804644735 @default.
- W4323664746 cites W2805791373 @default.
- W4323664746 cites W2845275599 @default.