Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323664904> ?p ?o ?g. }
- W4323664904 endingPage "112282" @default.
- W4323664904 startingPage "112282" @default.
- W4323664904 abstract "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a tremendous impact worldwide. Mapping virus-host interactions is critical to understand disease progression. MicroRNAs (miRNAs) are important RNA regulators, but their interaction with SARS-CoV-2 RNA was not experimentally investigated. Here, using Argonaute (AGO) cross-linking immunoprecipitation combined with RNA proximity ligation (CLEAR-CLIP), we provide unbiased mapping of SARS-CoV-2/miRNA interactions. We identified six main regions on the viral RNA bound primarily by one specific miRNA. Targeted mutagenesis and AGO1-3 knockdown demonstrated that these interactions are not critical for virus production. Moreover, we identified perturbed regulation of cellular miRNA interactions during infection, including non-compensated viral sequestration of the miR-15 family. Transcriptome analysis further showed that mRNAs targeted by this miRNA family are derepressed. This work delineates the interphase between miRNA regulation and SARS-CoV-2 infection and further contributes to deciphering the full molecular interactome of this virus." @default.
- W4323664904 created "2023-03-10" @default.
- W4323664904 creator A5000059912 @default.
- W4323664904 creator A5024205744 @default.
- W4323664904 creator A5035981470 @default.
- W4323664904 creator A5038234181 @default.
- W4323664904 creator A5044969044 @default.
- W4323664904 creator A5060835069 @default.
- W4323664904 creator A5065447488 @default.
- W4323664904 creator A5074871622 @default.
- W4323664904 creator A5084258898 @default.
- W4323664904 date "2023-04-01" @default.
- W4323664904 modified "2023-10-16" @default.
- W4323664904 title "Identification of the viral and cellular microRNA interactomes during SARS-CoV-2 infection" @default.
- W4323664904 cites W1967977640 @default.
- W4323664904 cites W1973094248 @default.
- W4323664904 cites W1986944906 @default.
- W4323664904 cites W2019130238 @default.
- W4323664904 cites W2026051181 @default.
- W4323664904 cites W2026570544 @default.
- W4323664904 cites W2114104545 @default.
- W4323664904 cites W2131271579 @default.
- W4323664904 cites W2131478115 @default.
- W4323664904 cites W2132803382 @default.
- W4323664904 cites W2138207763 @default.
- W4323664904 cites W2146512944 @default.
- W4323664904 cites W2169456326 @default.
- W4323664904 cites W2170830174 @default.
- W4323664904 cites W2180388440 @default.
- W4323664904 cites W2293422394 @default.
- W4323664904 cites W2341539131 @default.
- W4323664904 cites W2406250479 @default.
- W4323664904 cites W2610733803 @default.
- W4323664904 cites W2742785003 @default.
- W4323664904 cites W2887139865 @default.
- W4323664904 cites W2937256153 @default.
- W4323664904 cites W2952045272 @default.
- W4323664904 cites W2969979149 @default.
- W4323664904 cites W3001195213 @default.
- W4323664904 cites W3016489853 @default.
- W4323664904 cites W3017680297 @default.
- W4323664904 cites W3021271011 @default.
- W4323664904 cites W3022285953 @default.
- W4323664904 cites W3024609823 @default.
- W4323664904 cites W3084071750 @default.
- W4323664904 cites W3092296275 @default.
- W4323664904 cites W3093900830 @default.
- W4323664904 cites W3094597057 @default.
- W4323664904 cites W3095990266 @default.
- W4323664904 cites W3110976643 @default.
- W4323664904 cites W3114675079 @default.
- W4323664904 cites W3133935677 @default.
- W4323664904 cites W3134844657 @default.
- W4323664904 cites W3145471693 @default.
- W4323664904 cites W3158782644 @default.
- W4323664904 cites W3162879212 @default.
- W4323664904 cites W3165280603 @default.
- W4323664904 cites W3176803118 @default.
- W4323664904 cites W3195586308 @default.
- W4323664904 cites W3199743501 @default.
- W4323664904 cites W3217300869 @default.
- W4323664904 cites W4200267745 @default.
- W4323664904 cites W4200356903 @default.
- W4323664904 cites W4205163889 @default.
- W4323664904 cites W4205548061 @default.
- W4323664904 cites W4211064852 @default.
- W4323664904 cites W4220667558 @default.
- W4323664904 cites W4224792606 @default.
- W4323664904 cites W4225647030 @default.
- W4323664904 doi "https://doi.org/10.1016/j.celrep.2023.112282" @default.
- W4323664904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36961814" @default.
- W4323664904 hasPublicationYear "2023" @default.
- W4323664904 type Work @default.
- W4323664904 citedByCount "4" @default.
- W4323664904 countsByYear W43236649042023 @default.
- W4323664904 crossrefType "journal-article" @default.
- W4323664904 hasAuthorship W4323664904A5000059912 @default.
- W4323664904 hasAuthorship W4323664904A5024205744 @default.
- W4323664904 hasAuthorship W4323664904A5035981470 @default.
- W4323664904 hasAuthorship W4323664904A5038234181 @default.
- W4323664904 hasAuthorship W4323664904A5044969044 @default.
- W4323664904 hasAuthorship W4323664904A5060835069 @default.
- W4323664904 hasAuthorship W4323664904A5065447488 @default.
- W4323664904 hasAuthorship W4323664904A5074871622 @default.
- W4323664904 hasAuthorship W4323664904A5084258898 @default.
- W4323664904 hasBestOaLocation W43236649041 @default.
- W4323664904 hasConcept C104317684 @default.
- W4323664904 hasConcept C142724271 @default.
- W4323664904 hasConcept C145059251 @default.
- W4323664904 hasConcept C150194340 @default.
- W4323664904 hasConcept C162317418 @default.
- W4323664904 hasConcept C166703698 @default.
- W4323664904 hasConcept C173396325 @default.
- W4323664904 hasConcept C201853390 @default.
- W4323664904 hasConcept C2522874641 @default.
- W4323664904 hasConcept C2777648638 @default.
- W4323664904 hasConcept C2779134260 @default.
- W4323664904 hasConcept C3008058167 @default.