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• W4323666400 abstract "Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence. With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, gene editing has become efficient, convenient and programmable, leading to promising translational studies and clinical trials for both genetic and non-genetic diseases. A major concern in the applications of the CRISPR/Cas9 system is about its off-target effects, namely the deposition of unexpected, unwanted, or even adverse alterations to the genome. To date, many methods have been developed to nominate or detect the off-target sites of CRISPR/Cas9, which laid the basis for the successful upgrades of CRISPR/Cas9 derivatives with enhanced precision. In this review, we summarize these technological advancements and discuss about the current challenges in the management of off-target effects for future gene therapy." @default.
• W4323666400 created "2023-03-10" @default.
• W4323666400 creator A5000583736 @default.
• W4323666400 creator A5008825234 @default.
• W4323666400 creator A5061369579 @default.
• W4323666400 creator A5084882105 @default.
• W4323666400 date "2023-03-09" @default.
• W4323666400 modified "2023-10-05" @default.
• W4323666400 title "Off-target effects in CRISPR/Cas9 gene editing" @default.
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