Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323666795> ?p ?o ?g. }
- W4323666795 abstract "Parthenolide (PTL or PAR) was first isolated from Magnolia grandiflora and identified as a small molecule cancer inhibitor. PTL has the chemical structure of C15H20O3 with characteristics of sesquiterpene lactones and exhibits the biological property of inhibiting DNA biosynthesis of cancer cells. In this review, we summarise the recent research progress of medicinal PTL, including the therapeutic effects on skeletal diseases, cancers, and inflammation-induced cytokine storm. Mechanistic investigations reveal that PTL predominantly inhibits NF-κB activation and other signalling pathways, such as reactive oxygen species. As an inhibitor of NF-κB, PTL appears to inhibit several cytokines, including RANKL, TNF-α, IL-1β, together with LPS induced activation of NF-κB and NF-κB -mediated specific gene expression such as IL-1β, TNF-α, COX-2, iNOS, IL-8, MCP-1, RANTES, ICAM-1, VCAM-1. It is also proposed that PTL could inhibit cytokine storms or hypercytokinemia triggered by COVID-19 via blocking the activation of NF-κB signalling. Understanding the pharmacologic properties of PTL will assist us in developing its therapeutic application for medical conditions, including arthritis, osteolysis, periodontal disease, cancers, and COVID-19-related disease." @default.
- W4323666795 created "2023-03-10" @default.
- W4323666795 creator A5000990024 @default.
- W4323666795 creator A5001642071 @default.
- W4323666795 creator A5012767609 @default.
- W4323666795 creator A5026584286 @default.
- W4323666795 creator A5034208219 @default.
- W4323666795 creator A5048246608 @default.
- W4323666795 creator A5055580955 @default.
- W4323666795 creator A5060426945 @default.
- W4323666795 creator A5078183083 @default.
- W4323666795 date "2023-03-09" @default.
- W4323666795 modified "2023-09-28" @default.
- W4323666795 title "The therapeutic effect and mechanism of parthenolide in skeletal disease, cancers, and cytokine storm" @default.
- W4323666795 cites W149072091 @default.
- W4323666795 cites W1534148228 @default.
- W4323666795 cites W170138251 @default.
- W4323666795 cites W1963970520 @default.
- W4323666795 cites W1965416028 @default.
- W4323666795 cites W1968060268 @default.
- W4323666795 cites W1983347726 @default.
- W4323666795 cites W1983982834 @default.
- W4323666795 cites W1985769934 @default.
- W4323666795 cites W1989109779 @default.
- W4323666795 cites W1990481372 @default.
- W4323666795 cites W1994640655 @default.
- W4323666795 cites W1995269092 @default.
- W4323666795 cites W2001262486 @default.
- W4323666795 cites W2004288615 @default.
- W4323666795 cites W2007584648 @default.
- W4323666795 cites W2009466572 @default.
- W4323666795 cites W2021159269 @default.
- W4323666795 cites W2030029073 @default.
- W4323666795 cites W2044038461 @default.
- W4323666795 cites W2048254951 @default.
- W4323666795 cites W2049293744 @default.
- W4323666795 cites W2049795485 @default.
- W4323666795 cites W2053230550 @default.
- W4323666795 cites W2054176286 @default.
- W4323666795 cites W2057039052 @default.
- W4323666795 cites W2061460326 @default.
- W4323666795 cites W2063544464 @default.
- W4323666795 cites W2065741295 @default.
- W4323666795 cites W2066574904 @default.
- W4323666795 cites W2087366222 @default.
- W4323666795 cites W2087741508 @default.
- W4323666795 cites W2092396600 @default.
- W4323666795 cites W2099245838 @default.
- W4323666795 cites W2100087067 @default.
- W4323666795 cites W2101675525 @default.
- W4323666795 cites W2106785049 @default.
- W4323666795 cites W2109065738 @default.
- W4323666795 cites W2113548645 @default.
- W4323666795 cites W2114448663 @default.
- W4323666795 cites W2125698868 @default.
- W4323666795 cites W2127718009 @default.
- W4323666795 cites W2129242841 @default.
- W4323666795 cites W2134783524 @default.
- W4323666795 cites W2140051751 @default.
- W4323666795 cites W2140661425 @default.
- W4323666795 cites W2144106301 @default.
- W4323666795 cites W2146221750 @default.
- W4323666795 cites W2148124890 @default.
- W4323666795 cites W2149088071 @default.
- W4323666795 cites W2155421808 @default.
- W4323666795 cites W216444299 @default.
- W4323666795 cites W2165307476 @default.
- W4323666795 cites W2168488088 @default.
- W4323666795 cites W2170474721 @default.
- W4323666795 cites W2405787708 @default.
- W4323666795 cites W2408914493 @default.
- W4323666795 cites W2410301600 @default.
- W4323666795 cites W2550739849 @default.
- W4323666795 cites W2575747495 @default.
- W4323666795 cites W2580965938 @default.
- W4323666795 cites W2742444648 @default.
- W4323666795 cites W2744849939 @default.
- W4323666795 cites W2748612011 @default.
- W4323666795 cites W2751884637 @default.
- W4323666795 cites W2758587719 @default.
- W4323666795 cites W2782809052 @default.
- W4323666795 cites W2800577199 @default.
- W4323666795 cites W2802941600 @default.
- W4323666795 cites W2931974224 @default.
- W4323666795 cites W2969298962 @default.
- W4323666795 cites W3002149902 @default.
- W4323666795 cites W3012454642 @default.
- W4323666795 cites W3013283620 @default.
- W4323666795 cites W3015321334 @default.
- W4323666795 cites W3029543373 @default.
- W4323666795 cites W3036041989 @default.
- W4323666795 cites W3044898763 @default.
- W4323666795 cites W3045649287 @default.
- W4323666795 cites W3049380005 @default.
- W4323666795 cites W3080228553 @default.
- W4323666795 cites W3095079038 @default.
- W4323666795 cites W3096331115 @default.
- W4323666795 cites W3107851323 @default.
- W4323666795 cites W3108478283 @default.
- W4323666795 cites W3110713218 @default.