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- W4323668152 abstract "Chromosomal instability (CIN) has become a topic of great interest in recent years, not only for its implications in cancer diagnosis and prognosis but also for its role as an enabling feature and central hallmark of cancer. CIN describes cell-to-cell variation in the number or structure of chromosomes in a tumor population. Although extensive research in recent decades has identified some associations between CIN with response to therapy, specific associations with other hallmarks of cancer have not been fully evidenced. Such associations place CIN as an enabling feature of the other hallmarks of cancer and highlight the importance of deepening its knowledge to improve the outcome in cancer. In addition, studies conducted to date have shown paradoxical findings about the implications of CIN for therapeutic response, with some studies showing associations between high CIN and better therapeutic response, and others showing the opposite: associations between high CIN and therapeutic resistance. This evidences the complex relationships between CIN with the prognosis and response to treatment in cancer. Considering the above, this review focuses on recent studies on the role of CIN in cancer, the cellular mechanisms leading to CIN, its relationship with other hallmarks of cancer, and the emerging therapeutic approaches that are being developed to target such instability, with a primary focus on breast cancer. Further understanding of the complexity of CIN and its association with other hallmarks of cancer could provide a better understanding of the cellular and molecular mechanisms involved in prognosis and response to treatment in cancer and potentially lead to new drug targets." @default.
- W4323668152 created "2023-03-10" @default.
- W4323668152 creator A5002508977 @default.
- W4323668152 creator A5014059835 @default.
- W4323668152 creator A5022712155 @default.
- W4323668152 creator A5032143876 @default.
- W4323668152 creator A5062897620 @default.
- W4323668152 date "2023-03-01" @default.
- W4323668152 modified "2023-09-27" @default.
- W4323668152 title "Chromosomal Instability as Enabling Feature and Central Hallmark of Breast Cancer" @default.
- W4323668152 cites W1525325364 @default.
- W4323668152 cites W1544851750 @default.
- W4323668152 cites W1558526836 @default.
- W4323668152 cites W1558862631 @default.
- W4323668152 cites W1601755300 @default.
- W4323668152 cites W165062564 @default.
- W4323668152 cites W1789924039 @default.
- W4323668152 cites W1879756448 @default.
- W4323668152 cites W189719753 @default.
- W4323668152 cites W1920624926 @default.
- W4323668152 cites W1959848155 @default.
- W4323668152 cites W1963972004 @default.
- W4323668152 cites W1964724251 @default.
- W4323668152 cites W1966766863 @default.
- W4323668152 cites W1967304777 @default.
- W4323668152 cites W1968145208 @default.
- W4323668152 cites W1977345614 @default.
- W4323668152 cites W1978496694 @default.
- W4323668152 cites W1981427365 @default.
- W4323668152 cites W1984372257 @default.
- W4323668152 cites W1987512363 @default.
- W4323668152 cites W1990994003 @default.
- W4323668152 cites W1992762981 @default.
- W4323668152 cites W1993494709 @default.
- W4323668152 cites W1995445172 @default.
- W4323668152 cites W1997442618 @default.
- W4323668152 cites W2002246796 @default.
- W4323668152 cites W2002345411 @default.
- W4323668152 cites W2005961460 @default.
- W4323668152 cites W2006620593 @default.
- W4323668152 cites W2009427752 @default.
- W4323668152 cites W2010235804 @default.
- W4323668152 cites W2013306879 @default.
- W4323668152 cites W2014205228 @default.
- W4323668152 cites W2015182899 @default.
- W4323668152 cites W2015459776 @default.
- W4323668152 cites W2017046792 @default.
- W4323668152 cites W2017782528 @default.
- W4323668152 cites W2019892867 @default.
- W4323668152 cites W2020099456 @default.
- W4323668152 cites W2020755798 @default.
- W4323668152 cites W2025152046 @default.
- W4323668152 cites W2025708651 @default.
- W4323668152 cites W2028452487 @default.
- W4323668152 cites W2032040083 @default.
- W4323668152 cites W2032407757 @default.
- W4323668152 cites W2033779255 @default.
- W4323668152 cites W2034269086 @default.
- W4323668152 cites W2034813342 @default.
- W4323668152 cites W2035983112 @default.
- W4323668152 cites W2036008499 @default.
- W4323668152 cites W2037404897 @default.
- W4323668152 cites W2040154374 @default.
- W4323668152 cites W2040935952 @default.
- W4323668152 cites W2041140906 @default.
- W4323668152 cites W2043251251 @default.
- W4323668152 cites W2043527294 @default.
- W4323668152 cites W2044702943 @default.
- W4323668152 cites W2046264434 @default.
- W4323668152 cites W2047687247 @default.
- W4323668152 cites W2048039142 @default.
- W4323668152 cites W2051023078 @default.
- W4323668152 cites W2051940153 @default.
- W4323668152 cites W2057187298 @default.
- W4323668152 cites W2060123522 @default.
- W4323668152 cites W2063669247 @default.
- W4323668152 cites W2065796140 @default.
- W4323668152 cites W2067708830 @default.
- W4323668152 cites W2067897696 @default.
- W4323668152 cites W2069154035 @default.
- W4323668152 cites W2070419033 @default.
- W4323668152 cites W2070732038 @default.
- W4323668152 cites W2072023036 @default.
- W4323668152 cites W2074548008 @default.
- W4323668152 cites W2074669234 @default.
- W4323668152 cites W2076945188 @default.
- W4323668152 cites W2077145482 @default.
- W4323668152 cites W2077357367 @default.
- W4323668152 cites W2084818879 @default.
- W4323668152 cites W2089033365 @default.
- W4323668152 cites W2091205535 @default.
- W4323668152 cites W2095617425 @default.
- W4323668152 cites W2096283457 @default.
- W4323668152 cites W2096410299 @default.
- W4323668152 cites W2098005365 @default.
- W4323668152 cites W2100147739 @default.
- W4323668152 cites W2100375606 @default.
- W4323668152 cites W2102144390 @default.