Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323668197> ?p ?o ?g. }
- W4323668197 abstract "The development of new therapeutic strategies is on the increase for prostate cancer stem cells, owing to current standardized therapies for prostate cancer, including chemotherapy, androgen deprivation therapy (ADT), radiotherapy, and surgery, often failing because of tumor relapse ability. Ultimately, tumor relapse develops into advanced castration-resistant prostate cancer (CRPC), which becomes an irreversible and systemic disease. Hence, early identification of the intracellular components and molecular networks that promote prostate cancer is crucial for disease management and therapeutic intervention. One of the potential therapeutic methods for aggressive prostate cancer is to target prostate cancer stem cells (PCSCs), which appear to be a primary focal point of cancer metastasis and recurrence and are resistant to standardized therapies. PCSCs have also been documented to play a major role in regulating tumorigenesis, sphere formation, and the metastasis ability of prostate cancer with their stemness features. Therefore, the current review highlights the origin and identification of PCSCs and their role in anti-androgen resistance, as well as stemness-related signaling pathways. In addition, the review focuses on the current advanced therapeutic strategies for targeting PCSCs that are helping to prevent prostate cancer initiation and progression, such as microRNAs (miRNAs), nanotechnology, chemotherapy, immunotherapy, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing system, and photothermal ablation (PTA) therapy." @default.
- W4323668197 created "2023-03-10" @default.
- W4323668197 creator A5010749392 @default.
- W4323668197 creator A5013131489 @default.
- W4323668197 creator A5014589098 @default.
- W4323668197 creator A5015791582 @default.
- W4323668197 creator A5015945024 @default.
- W4323668197 creator A5019884903 @default.
- W4323668197 creator A5025290363 @default.
- W4323668197 creator A5045530749 @default.
- W4323668197 creator A5046228091 @default.
- W4323668197 creator A5062974431 @default.
- W4323668197 creator A5068131388 @default.
- W4323668197 creator A5089385918 @default.
- W4323668197 date "2023-03-09" @default.
- W4323668197 modified "2023-10-13" @default.
- W4323668197 title "State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer" @default.
- W4323668197 cites W1525789727 @default.
- W4323668197 cites W1541209562 @default.
- W4323668197 cites W1541370161 @default.
- W4323668197 cites W1546117988 @default.
- W4323668197 cites W1812119064 @default.
- W4323668197 cites W1964314383 @default.
- W4323668197 cites W1964641660 @default.
- W4323668197 cites W1967245224 @default.
- W4323668197 cites W1968786809 @default.
- W4323668197 cites W1969170077 @default.
- W4323668197 cites W1969600175 @default.
- W4323668197 cites W1969828120 @default.
- W4323668197 cites W1970623365 @default.
- W4323668197 cites W1971204432 @default.
- W4323668197 cites W1971707325 @default.
- W4323668197 cites W1973752700 @default.
- W4323668197 cites W1978656137 @default.
- W4323668197 cites W1987631767 @default.
- W4323668197 cites W1991066790 @default.
- W4323668197 cites W1992431968 @default.
- W4323668197 cites W2004618496 @default.
- W4323668197 cites W2004878973 @default.
- W4323668197 cites W2012619882 @default.
- W4323668197 cites W2014688699 @default.
- W4323668197 cites W2021950951 @default.
- W4323668197 cites W2025080966 @default.
- W4323668197 cites W2030197665 @default.
- W4323668197 cites W2033681249 @default.
- W4323668197 cites W2035271331 @default.
- W4323668197 cites W2036446168 @default.
- W4323668197 cites W2063110843 @default.
- W4323668197 cites W2069381736 @default.
- W4323668197 cites W2075349289 @default.
- W4323668197 cites W2077195956 @default.
- W4323668197 cites W2079467337 @default.
- W4323668197 cites W2092153754 @default.
- W4323668197 cites W2092642151 @default.
- W4323668197 cites W2093634040 @default.
- W4323668197 cites W2094252220 @default.
- W4323668197 cites W2100643538 @default.
- W4323668197 cites W2104510155 @default.
- W4323668197 cites W2107607313 @default.
- W4323668197 cites W2113417081 @default.
- W4323668197 cites W2114471035 @default.
- W4323668197 cites W2119105908 @default.
- W4323668197 cites W2122147062 @default.
- W4323668197 cites W2131952914 @default.
- W4323668197 cites W2132013820 @default.
- W4323668197 cites W2133532642 @default.
- W4323668197 cites W2141417189 @default.
- W4323668197 cites W2141666177 @default.
- W4323668197 cites W2145387574 @default.
- W4323668197 cites W2148554000 @default.
- W4323668197 cites W2151050931 @default.
- W4323668197 cites W2153382986 @default.
- W4323668197 cites W2155017336 @default.
- W4323668197 cites W2155199345 @default.
- W4323668197 cites W2156669098 @default.
- W4323668197 cites W2162250780 @default.
- W4323668197 cites W2170685293 @default.
- W4323668197 cites W2180958531 @default.
- W4323668197 cites W2198331127 @default.
- W4323668197 cites W2290217854 @default.
- W4323668197 cites W2301844380 @default.
- W4323668197 cites W2352943218 @default.
- W4323668197 cites W2493505337 @default.
- W4323668197 cites W2509134888 @default.
- W4323668197 cites W2521535110 @default.
- W4323668197 cites W2522813048 @default.
- W4323668197 cites W2547539064 @default.
- W4323668197 cites W2548679820 @default.
- W4323668197 cites W2553579606 @default.
- W4323668197 cites W2561008093 @default.
- W4323668197 cites W2567986926 @default.
- W4323668197 cites W2572109314 @default.
- W4323668197 cites W2581724956 @default.
- W4323668197 cites W2582081818 @default.
- W4323668197 cites W2585723656 @default.
- W4323668197 cites W2602876486 @default.
- W4323668197 cites W2604028302 @default.
- W4323668197 cites W2615231855 @default.
- W4323668197 cites W2625817416 @default.
- W4323668197 cites W2742001642 @default.