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• W4323669292 abstract "Abstract Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity. However, recent findings have forced us to reconsider this idea as several studies suggest AMPAergic scaling is not directly triggered by changes in spiking. Moreover, studies examining homeostatic perturbations in vivo have suggested that GABAergic synapses may be more critical in terms of spiking homeostasis. Here we show results that GABAergic scaling can act to homeostatically control spiking levels. We find that increased or decreased spiking in cortical cultures triggers multiplicative GABAergic upscaling and downscaling, respectively. In contrast, we find that changes in AMPAR or GABAR transmission only influence GABAergic scaling through their indirect effect on spiking. We propose that GABAergic scaling, rather than glutamatergic scaling, is a key player in spike rate homeostasis. Significance Statement The nervous system maintains excitability in order to perform network behaviors when called upon to do so. Networks are thought to maintain spiking levels through homeostatic synaptic scaling, where compensatory multiplicative changes in synaptic strength are observed following alterations in cellular spike rate. Although we demonstrated that AMPAergic synaptic scaling does not appear meet these criteria as a spike rate homeostat, we now show that GABAergic scaling does. Here we present evidence that the characteristics of GABAergic scaling place it in an excellent position to be a spiking homeostat. This work highlights the importance of inhibitory circuitry in the homeostatic control of excitability. Further, it provides a point of focus into neurodevelopmental disorders where excitability is impaired." @default.
• W4323669292 created "2023-03-10" @default.
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• W4323669292 date "2023-03-09" @default.
• W4323669292 modified "2023-09-26" @default.
• W4323669292 title "GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation" @default.
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• W4323669292 doi "https://doi.org/10.1101/2023.03.08.531789" @default.
• W4323669292 hasPublicationYear "2023" @default.
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