FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323812314> ?p ?o ?g. }

• W4323812314 endingPage "594" @default.
• W4323812314 startingPage "593" @default.
• W4323812314 abstract "Letter to the EditorDistal arterial bubble: an alternative mechanism underlying vestibular decompression illnessRan ArieliRan ArieliThe Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, IsraelEliachar Research Laboratory, Western Galilee Medical Center, Nahariya, IsraelPublished Online:10 Mar 2023https://doi.org/10.1152/japplphysiol.00003.2023MoreSectionsPDF (184 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations TO THE EDITOR: In their recent paper, Doolette and Mitchell (1) suggested that the extended lifetime of bubbles contributes to inner ear decompression illness (DCI). They attributed this to right-left shunt (PFO or IPAVA) of bubbles, which travel to the inner ear and expand while perfusion is low in the inner ear. They calculated bubble expansion by diffusion through a shell barrier surrounding the bubble for the assurance that the bubble survived the transit from heart/lungs to the inner ear. They also related the high incidence of excursions in saturation diving to the high pressure.We suggested that in a “distal arterial bubble” formation, in the bifurcating arterial tree, the vessel’s wall becomes thinner and wall surface to the volume of the vessel increases, both of these circumstances enhance inert gas diffusion from the surrounding tissue into the blood. A local reduction of blood flow, also leaves enough time to enhance inert gas diffusion from tissue into the blood. If an active hydrophobic spot (AHS) is located in the distal artery, the formed nanobubble at the AHS would develop into a decompression bubble. In repeated decompressions during a dive, a local bubble would remain almost stable because of a very small oxygen window in the arterial blood, and would continue to expand in following decompressions to a size that block the artery (2). We also suggested that vestibular DCI is related to distal arterial bubbles (3). Our suggested mechanism was supported by the occurrence of the following: very low vestibular perfusion; lower perfusion and more vestibular DCI in the right side as compared with the left side; occurrence of vestibular DCI in isobaric counter diffusion; and terminal arterioles that are longitudinal without collateral supply. In saturation dives, where excursions are common, the multiple decompressions should enhance the expansion of distal arterial bubble.The increased vestibular DCI with right-left shunt is not proof of bubble transfer. Shunted venous blood with a high load of inert gas may also enhance inert gas transfer into a sedentary distal arterial bubble. Diffusional growth of a stationary bubble adhering to an AHS is more likely than a bubble that flowed in the blood stream. The association of high venous bubbles (VGE) and vestibular DCI is not proof of cause and effect. The distribution of bubblers/nonbubblers in divers and in blood vessels of sheep is similar (4). Bubbling in sheep blood vessels is related to the amount of dipalmitoylphosphatidylcholine (DPPC) in the AHS (5). Therefore, a diver with high AHS is prone to both high VGE and high distal arterial bubble formation.It is not surprising that pain in joints and vestibular DCI are common in excursions in saturation dives. Both joints and vestibular organs are slow compartments, which become gas loaded in saturation dives. However, the mechanisms of DCI are different. Joint pain is most probably due to local expansion of nanobubbles at one of the four hydrophobic layers in the joint (6), and vestibular DCI was suggested to be related to distal arterial bubble formation.For their calculations, the authors used a shell surrounding the bubble. This shell was introduced to match the discrepancy between fast diffusional growth of a bubble to the delayed DCI. In some reports, diffusion coefficient was markedly reduced to adjust the timing of bubble expansion with the delayed DCI. The presence of such a shell has never been experimentally established. We demonstrated in blood vessels of sheep that the initiation of AHS (the formation of the first optically observed bubble (diameter 0.1 mm) is the function that governs the appearance of bubbles. This is a slow process, peaking 45 min after decompression (4, 7). Expansion of a bubble from 0.1 mm to 1 mm obeys simple diffusion and lasts ∼12 min. Therefore, I believe that the artificial induction of the shell is obsolete.DISCLOSURESNo conflicts of interest, financial or otherwise, are declared by the authors.AUTHOR CONTRIBUTIONSR.A. conceived and designed research; performed experiments; drafted manuscript; edited and revised manuscript; approved final version of manuscript.ACKNOWLEDGMENTSThe authors thank P. Braiman for skillful editing of the manuscript.REFERENCES1. Doolette DJ, Mitchell SJ. Extended lifetimes of bubbles at hyperbaric pressure may contribute to inner ear decompression sickness during saturation diving. J Appl Physiol (1985) 133: 517–523, 2022. doi:10.1152/japplphysiol.00121.2022.Link | ISI | Google Scholar2. Arieli R, Marmur A. A biophysical vascular bubble model for devising decompression procedures. Physiol Report 5: e13191, 2017. doi:10.14814/phy2.13191.Crossref | PubMed | Google Scholar3. Arieli R. Taravana, vestibular decompression illness, and autochthonous distal arterial bubbles. Respir Physiol Neurobiol 259: 119–121, 2019. doi:10.1016/j.resp.2018.08.010.Crossref | PubMed | ISI | Google Scholar4. Arieli R. Nanobubbles form at active hydrophobic spots on the luminal aspect of blood vessels: consequences for decompression illness in diving and possible implications for autoimmune disease – an overview. Front Physiol 8: 591, 2017. doi:10.3389/fphys.2017.00591.Crossref | PubMed | ISI | Google Scholar5. Arieli R, Khatib S, Vaya J. Ovine plasma dipalmitoylphosphatidylcholine does not Predict decompression bubbling. Respir Physiol Neurobiol 259: 26–29, 2019. doi:10.1016/j.resp.2018.06.013.Crossref | PubMed | ISI | Google Scholar6. Arieli R. Extravascular hydrophobic surfaces, fat droplets, and the connection with decompression illness: spinal, joint pain, and dysbaric osteonecrosis. Front Physiol 9: 305, 2018. doi:10.3389/fphys.2018.00305.Crossref | PubMed | ISI | Google Scholar7. Arieli R, Marmur A. Expansion of bubbles under a pulsatile flow regime in decompressed ovine blood vessels. Respir Physiol Neurobiol 222: 1–5, 2016. doi:10.1016/j.resp.2015.11.010.Crossref | PubMed | ISI | Google ScholarAUTHOR NOTESCorrespondence: R. Arieli ([email protected]com). Download PDF Previous Back to Top Next FiguresReferencesRelatedInformation Related ArticlesExtended lifetimes of bubbles at hyperbaric pressure may contribute to inner ear decompression sickness during saturation diving 24 Aug 2022Journal of Applied PhysiologyReply to Arieli 10 Mar 2023Journal of Applied PhysiologyCited ByReply to ArieliDavid J. Doolette and Simon J. Mitchell10 March 2023 | Journal of Applied Physiology, Vol. 134, No. 3 More from this issue > Volume 134Issue 3March 2023Pages 593-594 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/japplphysiol.00003.2023PubMed36897585History Received 3 January 2023 Accepted 18 January 2023 Published online 10 March 2023 Published in print 1 March 2023 Keywordsarterialbubbledecompressionillnessvestibular Metrics" @default.
• W4323812314 created "2023-03-11" @default.
• W4323812314 creator A5057334690 @default.
• W4323812314 date "2023-03-01" @default.
• W4323812314 modified "2023-10-18" @default.
• W4323812314 title "Distal arterial bubble: an alternative mechanism underlying vestibular decompression illness" @default.
• W4323812314 cites W2176696974 @default.
• W4323812314 cites W2597429189 @default.
• W4323812314 cites W2747805381 @default.
• W4323812314 cites W2795155313 @default.
• W4323812314 cites W2810837160 @default.
• W4323812314 cites W2888812615 @default.
• W4323812314 cites W4285388849 @default.
• W4323812314 doi "https://doi.org/10.1152/japplphysiol.00003.2023" @default.
• W4323812314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36897585" @default.
• W4323812314 hasPublicationYear "2023" @default.
• W4323812314 type Work @default.
• W4323812314 citedByCount "1" @default.
• W4323812314 countsByYear W43238123142023 @default.
• W4323812314 crossrefType "journal-article" @default.
• W4323812314 hasAuthorship W4323812314A5057334690 @default.
• W4323812314 hasConcept C121332964 @default.
• W4323812314 hasConcept C141071460 @default.
• W4323812314 hasConcept C164705383 @default.
• W4323812314 hasConcept C190041318 @default.
• W4323812314 hasConcept C2776102385 @default.
• W4323812314 hasConcept C2776957369 @default.
• W4323812314 hasConcept C2779480328 @default.
• W4323812314 hasConcept C42219234 @default.
• W4323812314 hasConcept C548259974 @default.
• W4323812314 hasConcept C62520636 @default.
• W4323812314 hasConcept C71924100 @default.
• W4323812314 hasConcept C89611455 @default.
• W4323812314 hasConcept C99508421 @default.
• W4323812314 hasConceptScore W4323812314C121332964 @default.
• W4323812314 hasConceptScore W4323812314C141071460 @default.
• W4323812314 hasConceptScore W4323812314C164705383 @default.
• W4323812314 hasConceptScore W4323812314C190041318 @default.
• W4323812314 hasConceptScore W4323812314C2776102385 @default.
• W4323812314 hasConceptScore W4323812314C2776957369 @default.
• W4323812314 hasConceptScore W4323812314C2779480328 @default.
• W4323812314 hasConceptScore W4323812314C42219234 @default.
• W4323812314 hasConceptScore W4323812314C548259974 @default.
• W4323812314 hasConceptScore W4323812314C62520636 @default.
• W4323812314 hasConceptScore W4323812314C71924100 @default.
• W4323812314 hasConceptScore W4323812314C89611455 @default.
• W4323812314 hasConceptScore W4323812314C99508421 @default.
• W4323812314 hasIssue "3" @default.
• W4323812314 hasLocation W43238123141 @default.
• W4323812314 hasLocation W43238123142 @default.
• W4323812314 hasOpenAccess W4323812314 @default.
• W4323812314 hasPrimaryLocation W43238123141 @default.
• W4323812314 hasRelatedWork W2159542929 @default.
• W4323812314 hasRelatedWork W2238275872 @default.
• W4323812314 hasRelatedWork W2260097738 @default.
• W4323812314 hasRelatedWork W2342509571 @default.
• W4323812314 hasRelatedWork W2344396202 @default.
• W4323812314 hasRelatedWork W2888812615 @default.
• W4323812314 hasRelatedWork W2889535210 @default.
• W4323812314 hasRelatedWork W4291990392 @default.
• W4323812314 hasRelatedWork W65731445 @default.
• W4323812314 hasRelatedWork W2115050174 @default.
• W4323812314 hasVolume "134" @default.
• W4323812314 isParatext "false" @default.
• W4323812314 isRetracted "false" @default.
• W4323812314 workType "article" @default.