Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323812946> ?p ?o ?g. }
- W4323812946 endingPage "321" @default.
- W4323812946 startingPage "310" @default.
- W4323812946 abstract "Abstract Context Active acromegaly is characterized by lipolysis-induced insulin resistance, which suggests adipose tissue (AT) as a primary driver of metabolic aberrations. Objective To study the gene expression landscape in AT in patients with acromegaly before and after disease control in order to understand the changes and to identify disease-specific biomarkers. Methods RNA sequencing was performed on paired subcutaneous adipose tissue (SAT) biopsies from six patients with acromegaly at time of diagnosis and after curative surgery. Clustering and pathway analyses were performed in order to identify disease activity-dependent genes. In a larger patient cohort (n = 23), the corresponding proteins were measured in serum by immunoassay. Correlations between growth hormone (GH), insulin-like growth factor I (IGF-I), visceral AT (VAT), SAT, total AT, and serum proteins were analyzed. Results 743 genes were significantly differentially expressed (P-adjusted < .05) in SAT before and after disease control. The patients clustered according to disease activity. Pathways related to inflammation, cell adhesion and extracellular matrix, GH and insulin signaling, and fatty acid oxidation were differentially expressed. Serum levels of HTRA1, METRNL, S100A8/A9, and PDGFD significantly increased after disease control (P < .05). VAT correlated with HTRA1 (R = 0.73) and S100A8/A9 (R = 0.55) (P < .05 for both). Conclusion AT in active acromegaly is associated with a gene expression profile of fibrosis and inflammation, which may corroborate the hyper-metabolic state and provide a means for identifying novel biomarkers." @default.
- W4323812946 created "2023-03-11" @default.
- W4323812946 creator A5001182090 @default.
- W4323812946 creator A5018035188 @default.
- W4323812946 creator A5028721986 @default.
- W4323812946 creator A5037691692 @default.
- W4323812946 creator A5039454537 @default.
- W4323812946 creator A5039625009 @default.
- W4323812946 creator A5057897297 @default.
- W4323812946 creator A5065909814 @default.
- W4323812946 creator A5082260079 @default.
- W4323812946 creator A5087620378 @default.
- W4323812946 creator A5090850055 @default.
- W4323812946 date "2023-03-02" @default.
- W4323812946 modified "2023-10-14" @default.
- W4323812946 title "Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly" @default.
- W4323812946 cites W1937157885 @default.
- W4323812946 cites W1969876154 @default.
- W4323812946 cites W2007608938 @default.
- W4323812946 cites W2008150005 @default.
- W4323812946 cites W2030925240 @default.
- W4323812946 cites W2034689063 @default.
- W4323812946 cites W2041777777 @default.
- W4323812946 cites W2045746881 @default.
- W4323812946 cites W2055801125 @default.
- W4323812946 cites W2072502978 @default.
- W4323812946 cites W2073081893 @default.
- W4323812946 cites W2094296565 @default.
- W4323812946 cites W2098425296 @default.
- W4323812946 cites W2100305481 @default.
- W4323812946 cites W2112914472 @default.
- W4323812946 cites W2119649463 @default.
- W4323812946 cites W2127372456 @default.
- W4323812946 cites W2131271579 @default.
- W4323812946 cites W2139407290 @default.
- W4323812946 cites W2140729960 @default.
- W4323812946 cites W2148537305 @default.
- W4323812946 cites W2154273881 @default.
- W4323812946 cites W2155465275 @default.
- W4323812946 cites W2160499824 @default.
- W4323812946 cites W2170551349 @default.
- W4323812946 cites W2274606925 @default.
- W4323812946 cites W2290830937 @default.
- W4323812946 cites W2436716005 @default.
- W4323812946 cites W2508487493 @default.
- W4323812946 cites W2612989432 @default.
- W4323812946 cites W2766946295 @default.
- W4323812946 cites W2776528345 @default.
- W4323812946 cites W2789635618 @default.
- W4323812946 cites W2790857957 @default.
- W4323812946 cites W2804961811 @default.
- W4323812946 cites W2884285576 @default.
- W4323812946 cites W2900569176 @default.
- W4323812946 cites W2917886281 @default.
- W4323812946 cites W2945066741 @default.
- W4323812946 cites W2945321494 @default.
- W4323812946 cites W2969660912 @default.
- W4323812946 cites W2994634487 @default.
- W4323812946 cites W3008982845 @default.
- W4323812946 cites W3009258273 @default.
- W4323812946 cites W3044374557 @default.
- W4323812946 cites W3086932070 @default.
- W4323812946 cites W3087636729 @default.
- W4323812946 cites W3164414550 @default.
- W4323812946 cites W4200363048 @default.
- W4323812946 cites W4221052809 @default.
- W4323812946 cites W4283392287 @default.
- W4323812946 cites W4283756870 @default.
- W4323812946 cites W4290075653 @default.
- W4323812946 doi "https://doi.org/10.1093/ejendo/lvad031" @default.
- W4323812946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36895180" @default.
- W4323812946 hasPublicationYear "2023" @default.
- W4323812946 type Work @default.
- W4323812946 citedByCount "1" @default.
- W4323812946 countsByYear W43238129462023 @default.
- W4323812946 crossrefType "journal-article" @default.
- W4323812946 hasAuthorship W4323812946A5001182090 @default.
- W4323812946 hasAuthorship W4323812946A5018035188 @default.
- W4323812946 hasAuthorship W4323812946A5028721986 @default.
- W4323812946 hasAuthorship W4323812946A5037691692 @default.
- W4323812946 hasAuthorship W4323812946A5039454537 @default.
- W4323812946 hasAuthorship W4323812946A5039625009 @default.
- W4323812946 hasAuthorship W4323812946A5057897297 @default.
- W4323812946 hasAuthorship W4323812946A5065909814 @default.
- W4323812946 hasAuthorship W4323812946A5082260079 @default.
- W4323812946 hasAuthorship W4323812946A5087620378 @default.
- W4323812946 hasAuthorship W4323812946A5090850055 @default.
- W4323812946 hasBestOaLocation W43238129461 @default.
- W4323812946 hasConcept C126322002 @default.
- W4323812946 hasConcept C134018914 @default.
- W4323812946 hasConcept C171089720 @default.
- W4323812946 hasConcept C2776914184 @default.
- W4323812946 hasConcept C2777391703 @default.
- W4323812946 hasConcept C2777433750 @default.
- W4323812946 hasConcept C2984496839 @default.
- W4323812946 hasConcept C555293320 @default.
- W4323812946 hasConcept C71315377 @default.
- W4323812946 hasConcept C71924100 @default.