Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323832767> ?p ?o ?g. }
- W4323832767 endingPage "114488" @default.
- W4323832767 startingPage "114488" @default.
- W4323832767 abstract "Triple negative breast cancer (TNBC) is a highly aggressive subtype with a poor prognosis due to its high rates of proliferation and metastasis. Recently, hydrogen sulfide (H2S) has been recognized as a novel gasotransmitter that plays a significant role in various pathological processes, including cancer. Here, we show that exogenous H2S inhibited TNBC cancer cell proliferation, migration and invasion in vitro, and also decreased cancer malignances in the mouse model of TNBC. To investigate the underlying mechanisms of H2S's anti-cancer effects in TNBC, we performed transcriptome sequencing and bioinformatic analyses. 2121 differentially expressed genes (DEGs) were revealed, and mainly enriched in cell cycle and DNA replication pathways. Further analysis revealed changes in alternative splicing after exogenous H2S treatment. Protein-protein interaction (PPI) network analysis was performed, which identified 458 interactions among 276 DEGs enriched in cell cycle and DNA replication pathways.We identified seven hub genes (MCM3, MCM4, MCM5, MCM6, CDC6, CDC45, and GINS2) through PPI network analysis, which were up-regulated in clinical human breast cancer but down-regulated after H2S treatment. Based on the hub genes selected, we developed a model predicting that exogenous H2S mainly exerts its anti-TNBC role by delaying DNA replication. Our findings suggest that exogenous H2S has potential as a therapeutic agent in TNBC and may exert its therapeutic potential through DNA replication and the cell cycle pathway." @default.
- W4323832767 created "2023-03-11" @default.
- W4323832767 creator A5013793241 @default.
- W4323832767 creator A5026368463 @default.
- W4323832767 creator A5033402218 @default.
- W4323832767 creator A5054823223 @default.
- W4323832767 creator A5062337245 @default.
- W4323832767 creator A5081675173 @default.
- W4323832767 date "2023-05-01" @default.
- W4323832767 modified "2023-09-29" @default.
- W4323832767 title "Exogenous hydrogen sulfide (H2S) exerts therapeutic potential in triple-negative breast cancer by affecting cell cycle and DNA replication pathway" @default.
- W4323832767 cites W1561285778 @default.
- W4323832767 cites W1946779803 @default.
- W4323832767 cites W1965832397 @default.
- W4323832767 cites W2028516053 @default.
- W4323832767 cites W2045615487 @default.
- W4323832767 cites W2104005232 @default.
- W4323832767 cites W2105106534 @default.
- W4323832767 cites W2107060225 @default.
- W4323832767 cites W2109936378 @default.
- W4323832767 cites W2113994981 @default.
- W4323832767 cites W2160101019 @default.
- W4323832767 cites W2299627520 @default.
- W4323832767 cites W2534359235 @default.
- W4323832767 cites W2803997671 @default.
- W4323832767 cites W2919631338 @default.
- W4323832767 cites W2946657092 @default.
- W4323832767 cites W2946899637 @default.
- W4323832767 cites W2947139788 @default.
- W4323832767 cites W2964849163 @default.
- W4323832767 cites W3003627105 @default.
- W4323832767 cites W3033869790 @default.
- W4323832767 cites W3107527779 @default.
- W4323832767 cites W3131964747 @default.
- W4323832767 cites W3156985612 @default.
- W4323832767 cites W3163351132 @default.
- W4323832767 cites W4226474386 @default.
- W4323832767 cites W4232865341 @default.
- W4323832767 cites W4281761948 @default.
- W4323832767 cites W634084859 @default.
- W4323832767 cites W71248295 @default.
- W4323832767 doi "https://doi.org/10.1016/j.biopha.2023.114488" @default.
- W4323832767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37002576" @default.
- W4323832767 hasPublicationYear "2023" @default.
- W4323832767 type Work @default.
- W4323832767 citedByCount "0" @default.
- W4323832767 crossrefType "journal-article" @default.
- W4323832767 hasAuthorship W4323832767A5013793241 @default.
- W4323832767 hasAuthorship W4323832767A5026368463 @default.
- W4323832767 hasAuthorship W4323832767A5033402218 @default.
- W4323832767 hasAuthorship W4323832767A5054823223 @default.
- W4323832767 hasAuthorship W4323832767A5062337245 @default.
- W4323832767 hasAuthorship W4323832767A5081675173 @default.
- W4323832767 hasBestOaLocation W43238327671 @default.
- W4323832767 hasConcept C104317684 @default.
- W4323832767 hasConcept C104690221 @default.
- W4323832767 hasConcept C121608353 @default.
- W4323832767 hasConcept C150194340 @default.
- W4323832767 hasConcept C162317418 @default.
- W4323832767 hasConcept C175193931 @default.
- W4323832767 hasConcept C2779013556 @default.
- W4323832767 hasConcept C2780110267 @default.
- W4323832767 hasConcept C29537977 @default.
- W4323832767 hasConcept C502942594 @default.
- W4323832767 hasConcept C530470458 @default.
- W4323832767 hasConcept C54355233 @default.
- W4323832767 hasConcept C62112901 @default.
- W4323832767 hasConcept C73573662 @default.
- W4323832767 hasConcept C86803240 @default.
- W4323832767 hasConcept C96232424 @default.
- W4323832767 hasConceptScore W4323832767C104317684 @default.
- W4323832767 hasConceptScore W4323832767C104690221 @default.
- W4323832767 hasConceptScore W4323832767C121608353 @default.
- W4323832767 hasConceptScore W4323832767C150194340 @default.
- W4323832767 hasConceptScore W4323832767C162317418 @default.
- W4323832767 hasConceptScore W4323832767C175193931 @default.
- W4323832767 hasConceptScore W4323832767C2779013556 @default.
- W4323832767 hasConceptScore W4323832767C2780110267 @default.
- W4323832767 hasConceptScore W4323832767C29537977 @default.
- W4323832767 hasConceptScore W4323832767C502942594 @default.
- W4323832767 hasConceptScore W4323832767C530470458 @default.
- W4323832767 hasConceptScore W4323832767C54355233 @default.
- W4323832767 hasConceptScore W4323832767C62112901 @default.
- W4323832767 hasConceptScore W4323832767C73573662 @default.
- W4323832767 hasConceptScore W4323832767C86803240 @default.
- W4323832767 hasConceptScore W4323832767C96232424 @default.
- W4323832767 hasLocation W43238327671 @default.
- W4323832767 hasLocation W43238327672 @default.
- W4323832767 hasOpenAccess W4323832767 @default.
- W4323832767 hasPrimaryLocation W43238327671 @default.
- W4323832767 hasRelatedWork W1499339123 @default.
- W4323832767 hasRelatedWork W1506003867 @default.
- W4323832767 hasRelatedWork W2121537719 @default.
- W4323832767 hasRelatedWork W2514025656 @default.
- W4323832767 hasRelatedWork W2568845480 @default.
- W4323832767 hasRelatedWork W2904294837 @default.
- W4323832767 hasRelatedWork W3173207637 @default.
- W4323832767 hasRelatedWork W3195094964 @default.