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• W4323843344 abstract "The control of cardiovascular risk factors, the promotion of a healthy lifestyle, and antithrombotic therapy are the cornerstones of secondary prevention after acute coronary syndrome (ACS). However, many patients have recurrent ischemic events despite the optimal control of traditional modifiable risk factors and the use of tailored pharmacological therapy, including new-generation antiplatelet and lipid-lowering agents. This evidence emphasizes the importance of identifying novel risk factors and targets to optimize secondary preventive strategies. Lipoprotein(a) (Lp(a)) has emerged as an independent predictor of adverse events after ACS. New molecules such as anti-PCSK9 monoclonal antibodies, small interfering RNAs, and antisense oligonucleotides can reduce plasma Lp(a) levels and are associated with a long-term outcome benefit after the index event. The inflammatory stimulus and the inflammasome, pivotal elements in the development and progression of atherosclerosis, have been widely investigated in patients with coronary artery disease. More recently, randomized clinical trials including post-ACS patients treated with colchicine and monoclonal antibodies targeting cytokines yielded promising results in the reduction in major cardiovascular events after an ACS. Gut dysbiosis has also raised great interest for its potential pathophysiological role in cardiovascular disease. This evidence, albeit preliminary and needing confirmation by larger population-based studies, suggests the possibility of targeting the gut microbiome in particularly high-risk populations. The risk of recurrent ischemic events after ACS is related to the complex interaction between intrinsic predisposing factors and environmental triggers. The identification of novel risk factors and targets is fundamental to customizing patient clinical management with a precision medicine perspective." @default.
• W4323843344 created "2023-03-11" @default.
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• W4323843344 date "2023-03-10" @default.
• W4323843344 modified "2023-10-14" @default.
• W4323843344 title "Secondary Cardiovascular Prevention after Acute Coronary Syndrome: Emerging Risk Factors and Novel Therapeutic Targets" @default.
• W4323843344 cites W1520609538 @default.
• W4323843344 cites W1529674879 @default.
• W4323843344 cites W1535151445 @default.
• W4323843344 cites W1559199308 @default.
• W4323843344 cites W1565401187 @default.
• W4323843344 cites W1751395982 @default.
• W4323843344 cites W1812416290 @default.
• W4323843344 cites W1910396151 @default.
• W4323843344 cites W1959291640 @default.
• W4323843344 cites W1972483153 @default.
• W4323843344 cites W1972614672 @default.
• W4323843344 cites W1980638155 @default.
• W4323843344 cites W1980914602 @default.
• W4323843344 cites W1983260286 @default.
• W4323843344 cites W1988163135 @default.
• W4323843344 cites W1990204315 @default.
• W4323843344 cites W1994699782 @default.
• W4323843344 cites W1994718207 @default.
• W4323843344 cites W1997089129 @default.
• W4323843344 cites W1998738857 @default.
• W4323843344 cites W2001044397 @default.
• W4323843344 cites W2002189205 @default.
• W4323843344 cites W2009978724 @default.
• W4323843344 cites W2013177932 @default.
• W4323843344 cites W2018327621 @default.
• W4323843344 cites W2022621797 @default.
• W4323843344 cites W2022928811 @default.
• W4323843344 cites W2024692328 @default.
• W4323843344 cites W2025267708 @default.
• W4323843344 cites W2028545985 @default.
• W4323843344 cites W2040247371 @default.
• W4323843344 cites W2049645198 @default.
• W4323843344 cites W2054544120 @default.
• W4323843344 cites W2060767467 @default.
• W4323843344 cites W2074977347 @default.
• W4323843344 cites W2078599166 @default.
• W4323843344 cites W2093631484 @default.
• W4323843344 cites W2093664978 @default.
• W4323843344 cites W2094941678 @default.
• W4323843344 cites W2095709591 @default.
• W4323843344 cites W2098230963 @default.
• W4323843344 cites W2104355263 @default.
• W4323843344 cites W2106951652 @default.
• W4323843344 cites W2113934014 @default.
• W4323843344 cites W2114576105 @default.
• W4323843344 cites W2115268091 @default.
• W4323843344 cites W2115944543 @default.
• W4323843344 cites W2118980586 @default.
• W4323843344 cites W2120972109 @default.
• W4323843344 cites W2129917444 @default.
• W4323843344 cites W2130541883 @default.
• W4323843344 cites W2131110587 @default.
• W4323843344 cites W2141358924 @default.
• W4323843344 cites W2142979519 @default.
• W4323843344 cites W2144479589 @default.
• W4323843344 cites W2151509838 @default.
• W4323843344 cites W2151749258 @default.
• W4323843344 cites W2155123856 @default.
• W4323843344 cites W2158945113 @default.
• W4323843344 cites W2160047369 @default.
• W4323843344 cites W2164089346 @default.
• W4323843344 cites W2165241435 @default.
• W4323843344 cites W2169252817 @default.
• W4323843344 cites W2169652175 @default.
• W4323843344 cites W2189713131 @default.
• W4323843344 cites W2219553649 @default.
• W4323843344 cites W2257321757 @default.
• W4323843344 cites W2285780972 @default.
• W4323843344 cites W2316112497 @default.
• W4323843344 cites W2320830719 @default.
• W4323843344 cites W2328023807 @default.
• W4323843344 cites W2340633221 @default.
• W4323843344 cites W2408838284 @default.
• W4323843344 cites W2430015321 @default.
• W4323843344 cites W2465758073 @default.
• W4323843344 cites W2486445835 @default.
• W4323843344 cites W2498232546 @default.
• W4323843344 cites W2522054313 @default.
• W4323843344 cites W2527872371 @default.
• W4323843344 cites W2536190224 @default.
• W4323843344 cites W2596179513 @default.
• W4323843344 cites W2607465490 @default.

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