Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323844364> ?p ?o ?g. }
- W4323844364 endingPage "717" @default.
- W4323844364 startingPage "717" @default.
- W4323844364 abstract "The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is partly under control by vaccination. However, highly potent and safe antiviral drugs for SARS-CoV-2 are still needed to avoid development of severe COVID-19. We report the discovery of a small molecule, Z-Tyr-Ala-CHN2, which was identified in a cell-based antiviral screen. The molecule exerts sub-micromolar antiviral activity against SARS-CoV-2, SARS-CoV-1, and human coronavirus 229E. Time-of-addition studies reveal that Z-Tyr-Ala-CHN2 acts at the early phase of the infection cycle, which is in line with the observation that the molecule inhibits cathepsin L. This results in antiviral activity against SARS-CoV-2 in VeroE6, A549-hACE2, and HeLa-hACE2 cells, but not in Caco-2 cells or primary human nasal epithelial cells since the latter two cell types also permit entry via transmembrane protease serine subtype 2 (TMPRSS2). Given their cell-specific activity, cathepsin L inhibitors still need to prove their value in the clinic; nevertheless, the activity profile of Z-Tyr-Ala-CHN2 makes it an interesting tool compound for studying the biology of coronavirus entry and replication." @default.
- W4323844364 created "2023-03-11" @default.
- W4323844364 creator A5004850261 @default.
- W4323844364 creator A5016861714 @default.
- W4323844364 creator A5017160342 @default.
- W4323844364 creator A5030947556 @default.
- W4323844364 creator A5036860979 @default.
- W4323844364 creator A5037934725 @default.
- W4323844364 creator A5040714564 @default.
- W4323844364 creator A5040747215 @default.
- W4323844364 creator A5048918542 @default.
- W4323844364 creator A5053077233 @default.
- W4323844364 creator A5061394488 @default.
- W4323844364 creator A5064367458 @default.
- W4323844364 creator A5065248443 @default.
- W4323844364 creator A5068177522 @default.
- W4323844364 creator A5069894218 @default.
- W4323844364 creator A5076440811 @default.
- W4323844364 creator A5079031319 @default.
- W4323844364 creator A5079163850 @default.
- W4323844364 creator A5083513303 @default.
- W4323844364 creator A5087632899 @default.
- W4323844364 creator A5089010495 @default.
- W4323844364 creator A5090483303 @default.
- W4323844364 date "2023-03-10" @default.
- W4323844364 modified "2023-10-14" @default.
- W4323844364 title "Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2" @default.
- W4323844364 cites W1837500998 @default.
- W4323844364 cites W1965411122 @default.
- W4323844364 cites W1967814129 @default.
- W4323844364 cites W2031071878 @default.
- W4323844364 cites W2031598641 @default.
- W4323844364 cites W2049879791 @default.
- W4323844364 cites W2062891727 @default.
- W4323844364 cites W2081719521 @default.
- W4323844364 cites W2086493164 @default.
- W4323844364 cites W2122991277 @default.
- W4323844364 cites W2136701859 @default.
- W4323844364 cites W2152808878 @default.
- W4323844364 cites W2165918411 @default.
- W4323844364 cites W2340522986 @default.
- W4323844364 cites W2531157227 @default.
- W4323844364 cites W2770333021 @default.
- W4323844364 cites W2948628743 @default.
- W4323844364 cites W2971120492 @default.
- W4323844364 cites W3005212621 @default.
- W4323844364 cites W3009912996 @default.
- W4323844364 cites W3012883269 @default.
- W4323844364 cites W3017258575 @default.
- W4323844364 cites W3023698680 @default.
- W4323844364 cites W3025091645 @default.
- W4323844364 cites W3034850094 @default.
- W4323844364 cites W3036391214 @default.
- W4323844364 cites W3082729388 @default.
- W4323844364 cites W3090108357 @default.
- W4323844364 cites W3110340454 @default.
- W4323844364 cites W3110844195 @default.
- W4323844364 cites W3118947400 @default.
- W4323844364 cites W3119203274 @default.
- W4323844364 cites W3120750707 @default.
- W4323844364 cites W3121391032 @default.
- W4323844364 cites W3126161304 @default.
- W4323844364 cites W3130163626 @default.
- W4323844364 cites W3133812656 @default.
- W4323844364 cites W3134674969 @default.
- W4323844364 cites W3150731319 @default.
- W4323844364 cites W3151076337 @default.
- W4323844364 cites W3158136279 @default.
- W4323844364 cites W3159672560 @default.
- W4323844364 cites W3173514762 @default.
- W4323844364 cites W3173547614 @default.
- W4323844364 cites W3180265430 @default.
- W4323844364 cites W3183799089 @default.
- W4323844364 cites W3185612186 @default.
- W4323844364 cites W3189544042 @default.
- W4323844364 cites W3190720733 @default.
- W4323844364 cites W3192523804 @default.
- W4323844364 cites W3193925925 @default.
- W4323844364 cites W3194430494 @default.
- W4323844364 cites W3196659412 @default.
- W4323844364 cites W3200454547 @default.
- W4323844364 cites W3200674187 @default.
- W4323844364 cites W3204417766 @default.
- W4323844364 cites W3206162646 @default.
- W4323844364 cites W3210049956 @default.
- W4323844364 cites W3211841439 @default.
- W4323844364 cites W3212389527 @default.
- W4323844364 cites W4200047841 @default.
- W4323844364 cites W4200051875 @default.
- W4323844364 cites W4200119590 @default.
- W4323844364 cites W4200317137 @default.
- W4323844364 cites W4200394432 @default.
- W4323844364 cites W4206109384 @default.
- W4323844364 cites W4206902820 @default.
- W4323844364 cites W4214636576 @default.
- W4323844364 cites W4221037810 @default.
- W4323844364 cites W4223419655 @default.
- W4323844364 cites W4224441516 @default.