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- W4323844530 abstract "Abstract Conventional nanozymes often possess low active site density. Pursuing effective strategies for constructing highly active single‐atomic nanosystems with maximum atom utilization efficiency is exceptionally attractive. Herein, we develop a facile “missing‐linker‐confined coordination” strategy to fabricate two self‐assembled nanozymes, i.e., conventional nanozyme (NE) and single‐atomic nanozyme (SAE), which respectively consist of Pt nanoparticles and single Pt atoms as active catalytic sites anchored in metal–organic frameworks (MOFs) with encapsulated photosensitizers for catalase‐mimicking enhanced photodynamic therapy. Compared to a Pt nanoparticle‐based conventional nanozyme, a Pt single‐atomic nanozyme shows enhanced catalase‐mimicking activity in generating oxygen for overcoming tumor hypoxia, thus exhibiting a more efficient reactive oxygen species generation and high tumor inhibition rate." @default.
- W4323844530 created "2023-03-11" @default.
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- W4323844530 date "2023-03-31" @default.
- W4323844530 modified "2023-09-26" @default.
- W4323844530 title "Missing‐Linker‐Confined Single‐Atomic Pt Nanozymes for Enzymatic Theranostics of Tumor" @default.
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- W4323844530 doi "https://doi.org/10.1002/ange.202217995" @default.
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