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- W4323848253 abstract "Background: Autophagy is a stress response mechanism that causes cellular components to degrade. Its defects were associated with multiple pathologies, including cancers. Thyroid cancer is known to be the most prevalent form of malignant neoplasm among endocrine tumors. The aim of the study was to seek and comprehensively explore the role of autophagy related genes and proteins play in thyroid cancers through bioinformatics analysis with their detection in the tissue samples. Methods: Bioinformatics analysis was performed to investigate autophagy related proteins and genes involvement in thyroid cancer progression. The experimental verification was done in cancer samples of one hundred and three patients with thyroid pathology included in the study. The miR-125blevel was detected by PCR in real time. Results and discussion: The bioinformatics analysis verified the miR-125b as a regulatory mechanism in autophagy. Its expression in patients with PTC was reduced by 6.75 times in cancer patients compared to the patients with benign tumors. The BRAFV600E mutations were associated with a decrease in hsa-miR-125b expression by 12.67 times compared to tumors with the wild-type gene. Conclusions: Our findings revealed involvement of the autophagy related proteins in cancer progression. The significant mechanisms of regulation are non-coding RNA sequences implicated in a variety of oncogenic processes. We found that miR-125b is a potential maker in thyroid cancer invasion, BRAV600E mutational status and risk of recurrence." @default.
- W4323848253 created "2023-03-11" @default.
- W4323848253 creator A5001809951 @default.
- W4323848253 creator A5012354078 @default.
- W4323848253 creator A5068250774 @default.
- W4323848253 creator A5077882123 @default.
- W4323848253 creator A5088221180 @default.
- W4323848253 date "2023-03-09" @default.
- W4323848253 modified "2023-09-25" @default.
- W4323848253 title "Autophagy-Related MicroRNA: Tumor miR-125b and Thyroid Cancers" @default.
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- W4323848253 doi "https://doi.org/10.3390/genes14030685" @default.
- W4323848253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36980957" @default.
- W4323848253 hasPublicationYear "2023" @default.