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- W4323850401 endingPage "5294" @default.
- W4323850401 startingPage "5294" @default.
- W4323850401 abstract "Epigenetic changes are heritable modifications that do not directly affect the DNA sequence. In cancer cells, the maintenance of a stable epigenetic profile can be crucial to support survival and proliferation, and said profile can differ significantly from that of healthy cells. The epigenetic profile of a cancer cell can be modulated by several factors, including metabolites. Recently, sphingolipids have emerged as novel modulators of epigenetic changes. Ceramide and sphingosine 1-phosphate have become well known in cancer due to activating anti-tumour and pro-tumour signalling pathways, respectively, and they have recently been shown to also induce several epigenetic modifications connected to cancer growth. Additionally, acellular factors in the tumour microenvironment, such as hypoxia and acidosis, are now recognised as crucial in promoting aggressiveness through several mechanisms, including epigenetic modifications. Here, we review the existing literature on sphingolipids, cancer, and epigenetic changes, with a focus on the interaction between these elements and components of the chemical tumour microenvironment." @default.
- W4323850401 created "2023-03-11" @default.
- W4323850401 creator A5026002068 @default.
- W4323850401 creator A5055307549 @default.
- W4323850401 creator A5071375881 @default.
- W4323850401 creator A5077687503 @default.
- W4323850401 date "2023-03-10" @default.
- W4323850401 modified "2023-09-26" @default.
- W4323850401 title "Epigenetic Regulation Mediated by Sphingolipids in Cancer" @default.
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