FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323874630> ?p ?o ?g. }

• W4323874630 endingPage "113" @default.
• W4323874630 startingPage "97" @default.
• W4323874630 abstract "In a line of transgenic mice (HpY-1), the pattern of expression of an olfactory marker protein (OMP)-lacZ fusion gene was analyzed in the cerebellum, where, in adult mice, OMP-lacZ was expressed primarily in Purkinje cells (PCs) of the posterior lobe. The transgene-expressing PCs were organized in parasagittal bands, with a boundary of expression roughly corresponding to the primary fissure that separates the cerebellum into anterior and posterior compartments. The regional expression of the lacZ gene was also analyzed during embryonic and postnatal development of the cerebellum. Within the cerebellum-isthmus region, transgene expression first was detected at embryonic day 13.5 (E13.5) in a cluster of postmitotic cells. By E14.5, lacZ was also expressed by a subpopulation of migrating PCs in the postisthmal and lateral cerebellar primordium, and, by E16.5, transgene-positive PCs formed caudally four sagittal bands symmetric to the medial embryonic fissure. The caudal pattern was retained in postnatal cerebella, where, by postnatal day 0 (P0), transgene-positive PCs in vermal lobules VIII and IX appeared to be organized in two prominent parasagittal compartments on either side of a negative midline band. In early postnatal animals, the transgene was expressed transiently in the anterior lobe vermis. Hence, from P5 onward, transgene expression appeared mostly restricted to the posterior lobe, where it followed a caudal-to-rostral gradient. In the paraflocculus, transgene-expressing PCs were confined to the rostrodorsal portion. The results indicate that the anterior and posterior cerebellar lobes are regulated by distinct ontogenetic programs, and PCs of functionally distinct cerebellar regions express the transgene differentially. Furthermore, the data suggest that ectopic expression of OMP-lacZ in the cerebellum is under the control of regulatory elements that provide positional information for the regional specification of PC subsets. J. Comp. Neurol. 404:97–113, 1999. © 1999 Wiley-Liss, Inc." @default.
• W4323874630 created "2023-03-12" @default.
• W4323874630 creator A5032764104 @default.
• W4323874630 creator A5071112592 @default.
• W4323874630 creator A5084705966 @default.
• W4323874630 creator A5086468108 @default.
• W4323874630 date "1999-02-01" @default.
• W4323874630 modified "2023-10-11" @default.
• W4323874630 title "Compartmental organization of Purkinje cells in the mature and developing mouse cerebellum as revealed by an olfactory marker protein-lacZ transgene" @default.
• W4323874630 cites W119651583 @default.
• W4323874630 cites W1486746333 @default.
• W4323874630 cites W1489850871 @default.
• W4323874630 cites W1545888483 @default.
• W4323874630 cites W1546277190 @default.
• W4323874630 cites W1556698386 @default.
• W4323874630 cites W1769796785 @default.
• W4323874630 cites W1860779656 @default.
• W4323874630 cites W1958208959 @default.
• W4323874630 cites W1965063265 @default.
• W4323874630 cites W1967016527 @default.
• W4323874630 cites W1973712279 @default.
• W4323874630 cites W1973862215 @default.
• W4323874630 cites W1979311571 @default.
• W4323874630 cites W1985550823 @default.
• W4323874630 cites W1990134475 @default.
• W4323874630 cites W1990643448 @default.
• W4323874630 cites W1991771956 @default.
• W4323874630 cites W1992002830 @default.
• W4323874630 cites W1993646910 @default.
• W4323874630 cites W1995112822 @default.
• W4323874630 cites W1996030000 @default.
• W4323874630 cites W1996886609 @default.
• W4323874630 cites W2003817603 @default.
• W4323874630 cites W2005706099 @default.
• W4323874630 cites W2007612979 @default.
• W4323874630 cites W2009615402 @default.
• W4323874630 cites W2012025122 @default.
• W4323874630 cites W2016479726 @default.
• W4323874630 cites W2018686727 @default.
• W4323874630 cites W2021083001 @default.
• W4323874630 cites W2023132914 @default.
• W4323874630 cites W2027727992 @default.
• W4323874630 cites W2027979299 @default.
• W4323874630 cites W2030380478 @default.
• W4323874630 cites W2030579630 @default.
• W4323874630 cites W2031913002 @default.
• W4323874630 cites W2035502959 @default.
• W4323874630 cites W2036042714 @default.
• W4323874630 cites W2036644268 @default.
• W4323874630 cites W2036741612 @default.
• W4323874630 cites W2037872212 @default.
• W4323874630 cites W2044982656 @default.
• W4323874630 cites W2054140261 @default.
• W4323874630 cites W2056003882 @default.
• W4323874630 cites W2058521476 @default.
• W4323874630 cites W2065305121 @default.
• W4323874630 cites W2065719271 @default.
• W4323874630 cites W2065970548 @default.
• W4323874630 cites W2066299151 @default.
• W4323874630 cites W2067818799 @default.
• W4323874630 cites W2073885140 @default.
• W4323874630 cites W2075541059 @default.
• W4323874630 cites W2079158042 @default.
• W4323874630 cites W2080034804 @default.
• W4323874630 cites W2083229965 @default.
• W4323874630 cites W2085415595 @default.
• W4323874630 cites W2085500666 @default.
• W4323874630 cites W2086705852 @default.
• W4323874630 cites W2088833100 @default.
• W4323874630 cites W2090896550 @default.
• W4323874630 cites W2091161055 @default.
• W4323874630 cites W2091626902 @default.
• W4323874630 cites W2092874909 @default.
• W4323874630 cites W2098596246 @default.
• W4323874630 cites W2111072594 @default.
• W4323874630 cites W2119800709 @default.
• W4323874630 cites W2121185017 @default.
• W4323874630 cites W2125795987 @default.
• W4323874630 cites W2133621011 @default.
• W4323874630 cites W2136648925 @default.
• W4323874630 cites W2136682392 @default.
• W4323874630 cites W2147678627 @default.
• W4323874630 cites W2148745966 @default.
• W4323874630 cites W2169053074 @default.
• W4323874630 cites W2256607555 @default.
• W4323874630 cites W2404690351 @default.
• W4323874630 cites W2883005241 @default.
• W4323874630 cites W4241507309 @default.
• W4323874630 cites W4253556663 @default.
• W4323874630 cites W4301377887 @default.
• W4323874630 doi "https://doi.org/10.1002/(sici)1096-9861(19990201)404:1<97::aid-cne8>3.0.co;2-1" @default.
• W4323874630 hasPublicationYear "1999" @default.
• W4323874630 type Work @default.
• W4323874630 citedByCount "24" @default.
• W4323874630 countsByYear W43238746302013 @default.
• W4323874630 countsByYear W43238746302015 @default.
• W4323874630 countsByYear W43238746302019 @default.
• W4323874630 countsByYear W43238746302021 @default.

• next