Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323920797> ?p ?o ?g. }
- W4323920797 abstract "We have purified ledodin, a cytotoxic 22-kDa protein from shiitake mushroom (Lentinula edodes) consisting of a 197 amino acid chain. Ledodin possessed N-glycosylase activity on the sarcin-ricin loop of mammalian 28S rRNA and inhibited protein synthesis. However, it was not active against insect, fungal, and bacterial ribosomes. In vitro and in silico studies suggested that ledodin exhibits a catalytic mechanism like that of DNA glycosylases and plant ribosome-inactivating proteins. Moreover, the sequence and structure of ledodin was not related to any protein of known function, although ledodin-homologous sequences were found in the genome of several species of fungi, some edible, belonging to different orders of the class Agaricomycetes. Therefore, ledodin could be the first of a new family of enzymes widely distributed among this class of basidiomycetes. The interest of these proteins lies both, in the fact that they can be a toxic agent of some edible mushrooms and in their application in medicine and biotechnology." @default.
- W4323920797 created "2023-03-12" @default.
- W4323920797 creator A5017550653 @default.
- W4323920797 creator A5021465415 @default.
- W4323920797 creator A5024725865 @default.
- W4323920797 creator A5025181549 @default.
- W4323920797 creator A5037194593 @default.
- W4323920797 creator A5060662876 @default.
- W4323920797 creator A5074002716 @default.
- W4323920797 creator A5083337154 @default.
- W4323920797 date "2023-03-28" @default.
- W4323920797 modified "2023-10-09" @default.
- W4323920797 title "Structural and functional characterization of the cytotoxic protein ledodin, an atypical ribosome‐inactivating protein from shiitake mushroom (<i>Lentinula edodes</i>)" @default.
- W4323920797 cites W1482431053 @default.
- W4323920797 cites W1498690712 @default.
- W4323920797 cites W1596712038 @default.
- W4323920797 cites W1985134451 @default.
- W4323920797 cites W1992710359 @default.
- W4323920797 cites W1996829946 @default.
- W4323920797 cites W1997503242 @default.
- W4323920797 cites W2017943378 @default.
- W4323920797 cites W2019061556 @default.
- W4323920797 cites W2035269009 @default.
- W4323920797 cites W2048049888 @default.
- W4323920797 cites W2055133784 @default.
- W4323920797 cites W2073637394 @default.
- W4323920797 cites W2092171535 @default.
- W4323920797 cites W2102206624 @default.
- W4323920797 cites W2105668062 @default.
- W4323920797 cites W2112959111 @default.
- W4323920797 cites W2127340311 @default.
- W4323920797 cites W2145946315 @default.
- W4323920797 cites W2152207030 @default.
- W4323920797 cites W2264239692 @default.
- W4323920797 cites W2288642384 @default.
- W4323920797 cites W2295635848 @default.
- W4323920797 cites W2568084568 @default.
- W4323920797 cites W2591266398 @default.
- W4323920797 cites W2742118221 @default.
- W4323920797 cites W2791833290 @default.
- W4323920797 cites W2809970753 @default.
- W4323920797 cites W2810198252 @default.
- W4323920797 cites W2904020092 @default.
- W4323920797 cites W2943378437 @default.
- W4323920797 cites W2947288025 @default.
- W4323920797 cites W2954540675 @default.
- W4323920797 cites W2983673860 @default.
- W4323920797 cites W3121908550 @default.
- W4323920797 cites W3155220196 @default.
- W4323920797 cites W3163872934 @default.
- W4323920797 cites W3177828909 @default.
- W4323920797 cites W3186179742 @default.
- W4323920797 cites W3193338507 @default.
- W4323920797 cites W3196062290 @default.
- W4323920797 cites W3210597669 @default.
- W4323920797 cites W3215814154 @default.
- W4323920797 cites W4211049190 @default.
- W4323920797 cites W4251751280 @default.
- W4323920797 cites W4282918386 @default.
- W4323920797 cites W4292575017 @default.
- W4323920797 cites W4294169795 @default.
- W4323920797 cites W4323920797 @default.
- W4323920797 doi "https://doi.org/10.1002/pro.4621" @default.
- W4323920797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36905289" @default.
- W4323920797 hasPublicationYear "2023" @default.
- W4323920797 type Work @default.
- W4323920797 citedByCount "3" @default.
- W4323920797 countsByYear W43239207972023 @default.
- W4323920797 crossrefType "journal-article" @default.
- W4323920797 hasAuthorship W4323920797A5017550653 @default.
- W4323920797 hasAuthorship W4323920797A5021465415 @default.
- W4323920797 hasAuthorship W4323920797A5024725865 @default.
- W4323920797 hasAuthorship W4323920797A5025181549 @default.
- W4323920797 hasAuthorship W4323920797A5037194593 @default.
- W4323920797 hasAuthorship W4323920797A5060662876 @default.
- W4323920797 hasAuthorship W4323920797A5074002716 @default.
- W4323920797 hasAuthorship W4323920797A5083337154 @default.
- W4323920797 hasBestOaLocation W43239207971 @default.
- W4323920797 hasConcept C104317684 @default.
- W4323920797 hasConcept C134935766 @default.
- W4323920797 hasConcept C192396546 @default.
- W4323920797 hasConcept C2776236347 @default.
- W4323920797 hasConcept C2776474821 @default.
- W4323920797 hasConcept C2777200438 @default.
- W4323920797 hasConcept C2777367657 @default.
- W4323920797 hasConcept C2780128948 @default.
- W4323920797 hasConcept C552990157 @default.
- W4323920797 hasConcept C55493867 @default.
- W4323920797 hasConcept C59822182 @default.
- W4323920797 hasConcept C67705224 @default.
- W4323920797 hasConcept C67905577 @default.
- W4323920797 hasConcept C86803240 @default.
- W4323920797 hasConcept C88478588 @default.
- W4323920797 hasConceptScore W4323920797C104317684 @default.
- W4323920797 hasConceptScore W4323920797C134935766 @default.
- W4323920797 hasConceptScore W4323920797C192396546 @default.
- W4323920797 hasConceptScore W4323920797C2776236347 @default.
- W4323920797 hasConceptScore W4323920797C2776474821 @default.
- W4323920797 hasConceptScore W4323920797C2777200438 @default.
- W4323920797 hasConceptScore W4323920797C2777367657 @default.