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- W4323920985 abstract "Abstract Niche cells are widely known to regulate stem/progenitor cells in many mammalian tissues. In the hair, dermal papilla niche cells are well accepted to regulate hair stem/progenitor cells. However, how niche cells themselves are maintained is largely unknown. We present evidence implicating hair matrix progenitors and the lipid modifying enzyme, Stearoyl CoA Desaturase 1, in the regulation of the dermal papilla niche during the anagen-catagen transition of the mouse hair cycle. Our data suggest that this takes place via autocrine Wnt signalling and paracrine Hedgehog signalling. To our knowledge, this is the first report demonstrating a potential role for matrix progenitor cells in maintaining the dermal papilla niche." @default.
- W4323920985 created "2023-03-12" @default.
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- W4323920985 date "2023-03-10" @default.
- W4323920985 modified "2023-10-14" @default.
- W4323920985 title "Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche" @default.
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- W4323920985 doi "https://doi.org/10.1038/s41598-023-30411-7" @default.
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- W4323920985 hasPublicationYear "2023" @default.
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