FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323923145> ?p ?o ?g. }

• W4323923145 endingPage "12" @default.
• W4323923145 startingPage "1" @default.
• W4323923145 abstract "The valorization of Crocus sativus focuses mainly on the plant’s stigma because it is one of the most expensive and valuable spices in the world and has great value in the food, cosmetics, and pharmacological industries. Due to this high stigma value, the other parts of the plant are considered as by-products; our study aimed to evaluate the myorelaxant and antispasmodic activities of the byproducts (tepals and leaves) to compare them with the stigma of the plant. To investigate the myorelaxant and antispasmodic activities of the Crocus sativus on isolated rabbit and rat jejunum, we used an in vitro technic with an organ bath and an isotonic transducer. Our results showed that the STG (hydroethanolic extract of stigmas) and LV (hydroethanolic extract of leaves) had a moderate myorelaxant effect with IC50 = 6.61 ± 1.5 and 5.08 ± 0.45 mg/ml, respectively. TPL (hydroethanolic extract of tepals) had a significant ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>p</mi> <mo>˂</mo> <mn>0.001</mn> </math> ) inhibitory effect on the amplitude of the rabbit jejunum basic contractions with an IC50 = 1.36 ± 0.15 mg/ml. TPL also caused a significant ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>p</mi> <mo>˂</mo> <mn>0.001</mn> </math> ) antispasmodic activity depending on the dose of the contraction induced by CCh (10−6 M) and KCl (25 mM). The antispasmodic effect of the TPL is slightly altered in the presence of nifedipine by a percentage of 26.8%. This difference is statistically significant ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>p</mi> <mo>˂</mo> <mn>0.01</mn> </math> ). Therefore, the extract could induce the inhibitory effect on L-type voltage-dependent Ca2+ channels, but not on the guanylate cyclase and nitric oxide pathways. That confirmed that the TPL has a comparable effect to the verapamil. The HPLC-DAD analysis of various parts of C. sativus shows that the three extracts contain the kaempferol flavanol compound, the STG also was revealed to be rich in carotenoids crocin, and these isomers are trans and cis-crocin, safranal, and picrocrocin. In contrast, the TPL revealed the presence of isorhamnetin and quercetin, but the LV was rich in hesperidin and mangiferin. In conclusion, this study supports the traditional use of this plant to treat digestive problems and will allow us to explore future possibilities for treating bowel spasms using natural molecules derived from saffron." @default.
• W4323923145 created "2023-03-12" @default.
• W4323923145 creator A5008685992 @default.
• W4323923145 creator A5008886392 @default.
• W4323923145 creator A5016230067 @default.
• W4323923145 creator A5025940022 @default.
• W4323923145 creator A5032982330 @default.
• W4323923145 creator A5037737856 @default.
• W4323923145 creator A5043475596 @default.
• W4323923145 creator A5053151749 @default.
• W4323923145 creator A5078393967 @default.
• W4323923145 creator A5079912102 @default.
• W4323923145 creator A5080065417 @default.
• W4323923145 creator A5084519106 @default.
• W4323923145 date "2023-03-10" @default.
• W4323923145 modified "2023-10-18" @default.
• W4323923145 title "In Vitro Assessment of Myorelaxant and Antispasmodic Effects of Stigmas, Tepals, and Leaves Hydroethanolic Extracts of Crocus sativus" @default.
• W4323923145 cites W1971989349 @default.
• W4323923145 cites W1976176778 @default.
• W4323923145 cites W1981321748 @default.
• W4323923145 cites W1983523072 @default.
• W4323923145 cites W1986325598 @default.
• W4323923145 cites W2007128090 @default.
• W4323923145 cites W2016769131 @default.
• W4323923145 cites W2031466740 @default.
• W4323923145 cites W2032922770 @default.
• W4323923145 cites W2035514405 @default.
• W4323923145 cites W2050679620 @default.
• W4323923145 cites W2051662189 @default.
• W4323923145 cites W2061229425 @default.
• W4323923145 cites W2069601103 @default.
• W4323923145 cites W2075535804 @default.
• W4323923145 cites W2092977773 @default.
• W4323923145 cites W2112166832 @default.
• W4323923145 cites W2141978431 @default.
• W4323923145 cites W2150397487 @default.
• W4323923145 cites W2173520866 @default.
• W4323923145 cites W2178990939 @default.
• W4323923145 cites W2332342832 @default.
• W4323923145 cites W2513301959 @default.
• W4323923145 cites W2538247425 @default.
• W4323923145 cites W2564125965 @default.
• W4323923145 cites W2590822711 @default.
• W4323923145 cites W2607735059 @default.
• W4323923145 cites W2792336677 @default.
• W4323923145 cites W2801172852 @default.
• W4323923145 cites W2802595827 @default.
• W4323923145 cites W2898404024 @default.
• W4323923145 cites W2941373250 @default.
• W4323923145 cites W2985773823 @default.
• W4323923145 cites W3106143244 @default.
• W4323923145 cites W3126718331 @default.
• W4323923145 cites W3146427213 @default.
• W4323923145 cites W3166215822 @default.
• W4323923145 cites W3186794468 @default.
• W4323923145 cites W3198390820 @default.
• W4323923145 cites W3199051252 @default.
• W4323923145 cites W4214828466 @default.
• W4323923145 cites W4221019367 @default.
• W4323923145 cites W4224290181 @default.
• W4323923145 cites W4226169959 @default.
• W4323923145 cites W4229442464 @default.
• W4323923145 cites W4232997031 @default.
• W4323923145 cites W4281392514 @default.
• W4323923145 cites W4296499647 @default.
• W4323923145 cites W4298325582 @default.
• W4323923145 cites W4309814668 @default.
• W4323923145 cites W4312489890 @default.
• W4323923145 doi "https://doi.org/10.1155/2023/4165305" @default.
• W4323923145 hasPublicationYear "2023" @default.
• W4323923145 type Work @default.
• W4323923145 citedByCount "2" @default.
• W4323923145 countsByYear W43239231452023 @default.
• W4323923145 crossrefType "journal-article" @default.
• W4323923145 hasAuthorship W4323923145A5008685992 @default.
• W4323923145 hasAuthorship W4323923145A5008886392 @default.
• W4323923145 hasAuthorship W4323923145A5016230067 @default.
• W4323923145 hasAuthorship W4323923145A5025940022 @default.
• W4323923145 hasAuthorship W4323923145A5032982330 @default.
• W4323923145 hasAuthorship W4323923145A5037737856 @default.
• W4323923145 hasAuthorship W4323923145A5043475596 @default.
• W4323923145 hasAuthorship W4323923145A5053151749 @default.
• W4323923145 hasAuthorship W4323923145A5078393967 @default.
• W4323923145 hasAuthorship W4323923145A5079912102 @default.
• W4323923145 hasAuthorship W4323923145A5080065417 @default.
• W4323923145 hasAuthorship W4323923145A5084519106 @default.
• W4323923145 hasBestOaLocation W43239231451 @default.
• W4323923145 hasConcept C185592680 @default.
• W4323923145 hasConcept C2776366702 @default.
• W4323923145 hasConcept C2776798904 @default.
• W4323923145 hasConcept C2779571273 @default.
• W4323923145 hasConcept C31903555 @default.
• W4323923145 hasConcept C55493867 @default.
• W4323923145 hasConcept C556039675 @default.
• W4323923145 hasConcept C71924100 @default.
• W4323923145 hasConcept C86803240 @default.
• W4323923145 hasConcept C98274493 @default.
• W4323923145 hasConceptScore W4323923145C185592680 @default.

• next