Matches in SemOpenAlex for { <https://semopenalex.org/work/W4323924744> ?p ?o ?g. }
- W4323924744 endingPage "286" @default.
- W4323924744 startingPage "276" @default.
- W4323924744 abstract "Reinvigorating the function of exhausted CD8+ T cells during chronic viral infection and cancer is a major goal of current immunotherapy regimens. Here, we discuss recent advances in our understanding of exhausted CD8+ T cell heterogeneity as well as the potential differentiation trajectories that exhausted T cells follow during chronic infection and/or cancer. We highlight surmounting evidence suggesting that some T cell clones are divergent in nature and can develop into either terminally differentiated effector or exhausted CD8+ T cells. Lastly, we consider the potential therapeutic implications of such a bifurcation model of CD8+ T cell differentiation, including the intriguing hypothesis that redirecting progenitor CD8+ T cell differentiation along an effector pathway may serve as a novel approach to mitigate T cell exhaustion." @default.
- W4323924744 created "2023-03-12" @default.
- W4323924744 creator A5010487423 @default.
- W4323924744 creator A5018011487 @default.
- W4323924744 date "2023-04-01" @default.
- W4323924744 modified "2023-10-18" @default.
- W4323924744 title "Exhausted CD8+ T cells face a developmental fork in the road" @default.
- W4323924744 cites W1493344427 @default.
- W4323924744 cites W1914112386 @default.
- W4323924744 cites W1979773132 @default.
- W4323924744 cites W1985774274 @default.
- W4323924744 cites W2037610638 @default.
- W4323924744 cites W2053463299 @default.
- W4323924744 cites W2076268623 @default.
- W4323924744 cites W2077116159 @default.
- W4323924744 cites W2083331853 @default.
- W4323924744 cites W2094000075 @default.
- W4323924744 cites W2097855813 @default.
- W4323924744 cites W2099468505 @default.
- W4323924744 cites W2110305039 @default.
- W4323924744 cites W2119896120 @default.
- W4323924744 cites W2124969212 @default.
- W4323924744 cites W2124984983 @default.
- W4323924744 cites W2144882745 @default.
- W4323924744 cites W2150492554 @default.
- W4323924744 cites W2155025120 @default.
- W4323924744 cites W2163001100 @default.
- W4323924744 cites W2497442705 @default.
- W4323924744 cites W2506616866 @default.
- W4323924744 cites W2513922839 @default.
- W4323924744 cites W2536157342 @default.
- W4323924744 cites W2541574334 @default.
- W4323924744 cites W2545009331 @default.
- W4323924744 cites W2797429263 @default.
- W4323924744 cites W2800641869 @default.
- W4323924744 cites W2889555301 @default.
- W4323924744 cites W2899145148 @default.
- W4323924744 cites W2909486828 @default.
- W4323924744 cites W2912648593 @default.
- W4323924744 cites W2913558101 @default.
- W4323924744 cites W2917547201 @default.
- W4323924744 cites W2950413690 @default.
- W4323924744 cites W2951520325 @default.
- W4323924744 cites W2952815301 @default.
- W4323924744 cites W2974612518 @default.
- W4323924744 cites W2978325001 @default.
- W4323924744 cites W2991888163 @default.
- W4323924744 cites W2994331021 @default.
- W4323924744 cites W3020888809 @default.
- W4323924744 cites W3028523516 @default.
- W4323924744 cites W3081505604 @default.
- W4323924744 cites W3090720142 @default.
- W4323924744 cites W3133736305 @default.
- W4323924744 cites W3135828336 @default.
- W4323924744 cites W3137408549 @default.
- W4323924744 cites W3165838483 @default.
- W4323924744 cites W3183617093 @default.
- W4323924744 cites W3183788950 @default.
- W4323924744 cites W3198005493 @default.
- W4323924744 cites W3211956859 @default.
- W4323924744 cites W4200468913 @default.
- W4323924744 cites W4281658223 @default.
- W4323924744 cites W4292121925 @default.
- W4323924744 cites W4297497772 @default.
- W4323924744 cites W4297497801 @default.
- W4323924744 cites W4307040885 @default.
- W4323924744 cites W4307429713 @default.
- W4323924744 cites W4307890047 @default.
- W4323924744 cites W4314937969 @default.
- W4323924744 doi "https://doi.org/10.1016/j.it.2023.02.006" @default.
- W4323924744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36907685" @default.
- W4323924744 hasPublicationYear "2023" @default.
- W4323924744 type Work @default.
- W4323924744 citedByCount "3" @default.
- W4323924744 countsByYear W43239247442023 @default.
- W4323924744 crossrefType "journal-article" @default.
- W4323924744 hasAuthorship W4323924744A5010487423 @default.
- W4323924744 hasAuthorship W4323924744A5018011487 @default.
- W4323924744 hasConcept C154317977 @default.
- W4323924744 hasConcept C15729860 @default.
- W4323924744 hasConcept C167672396 @default.
- W4323924744 hasConcept C201750760 @default.
- W4323924744 hasConcept C202751555 @default.
- W4323924744 hasConcept C203014093 @default.
- W4323924744 hasConcept C2776090121 @default.
- W4323924744 hasConcept C2777701055 @default.
- W4323924744 hasConcept C28328180 @default.
- W4323924744 hasConcept C51785407 @default.
- W4323924744 hasConcept C54355233 @default.
- W4323924744 hasConcept C86803240 @default.
- W4323924744 hasConcept C8891405 @default.
- W4323924744 hasConcept C95444343 @default.
- W4323924744 hasConceptScore W4323924744C154317977 @default.
- W4323924744 hasConceptScore W4323924744C15729860 @default.
- W4323924744 hasConceptScore W4323924744C167672396 @default.
- W4323924744 hasConceptScore W4323924744C201750760 @default.
- W4323924744 hasConceptScore W4323924744C202751555 @default.
- W4323924744 hasConceptScore W4323924744C203014093 @default.